Current views on the population structure of plasmodium falciparum: Implications for control

1997 ◽  
Vol 13 (7) ◽  
pp. 262-267 ◽  
Author(s):  
H.A. Babiker ◽  
D. Walliker
2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Fehintola V. Ajogbasile ◽  
Adeyemi T. Kayode ◽  
Paul E. Oluniyi ◽  
Kazeem O. Akano ◽  
Jessica N. Uwanibe ◽  
...  

Abstract Background Malaria remains a public health burden especially in Nigeria. To develop new malaria control and elimination strategies or refine existing ones, understanding parasite population diversity and transmission patterns is crucial. Methods In this study, characterization of the parasite diversity and structure of Plasmodium falciparum isolates from 633 dried blood spot samples in Nigeria was carried out using 12 microsatellite loci of P. falciparum. These microsatellite loci were amplified via semi-nested polymerase chain reaction (PCR) and fragments were analysed using population genetic tools. Results Estimates of parasite genetic diversity, such as mean number of different alleles (13.52), effective alleles (7.13), allelic richness (11.15) and expected heterozygosity (0.804), were high. Overall linkage disequilibrium was weak (0.006, P < 0.001). Parasite population structure was low (Fst: 0.008–0.105, AMOVA: 0.039). Conclusion The high level of parasite genetic diversity and low population structuring in this study suggests that parasite populations circulating in Nigeria are homogenous. However, higher resolution methods, such as the 24 SNP barcode and whole genome sequencing, may capture more specific parasite genetic signatures circulating in the country. The results obtained can be used as a baseline for parasite genetic diversity and structure, aiding in the formulation of appropriate therapeutic and control strategies in Nigeria.


2013 ◽  
Vol 3 (1) ◽  
Author(s):  
Natalie M. Bowman ◽  
Seth Congdon ◽  
Tisungane Mvalo ◽  
Jaymin C. Patel ◽  
Veronica Escamilla ◽  
...  

2005 ◽  
Vol 102 (48) ◽  
pp. 17388-17393 ◽  
Author(s):  
F. G. Razakandrainibe ◽  
P. Durand ◽  
J. C. Koella ◽  
T. De Meeus ◽  
F. Rousset ◽  
...  

Acta Tropica ◽  
1994 ◽  
Vol 58 (1) ◽  
pp. 13-19 ◽  
Author(s):  
Bruce H. Noden ◽  
Patrick S. Beadle ◽  
Jefferson A. Vaughan ◽  
Charles B. Pumpuni ◽  
Melissa D. Kent ◽  
...  

2001 ◽  
Vol 17 (8) ◽  
pp. 351-353 ◽  
Author(s):  
Philip Awadalla ◽  
David Walliker ◽  
Hamza Babiker ◽  
Margaret Mackinnon

2009 ◽  
Vol 8 (1) ◽  
pp. 155 ◽  
Author(s):  
Tepanata Pumpaibool ◽  
Céline Arnathau ◽  
Patrick Durand ◽  
Naowarat Kanchanakhan ◽  
Napaporn Siripoon ◽  
...  

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