Role of d�collement material with different rheological properties in the structure of the Aljibe thrust imbricate (Flysch Trough, Gibraltar Arc): an analogue modelling approach

2003 ◽  
Vol 25 (6) ◽  
pp. 867-881 ◽  
Author(s):  
M LUJAN
2018 ◽  
Vol 21 (3) ◽  
pp. 1800696 ◽  
Author(s):  
Muntaz Hana Ahmad Khairi ◽  
Saiful Amri Mazlan ◽  
Ubaidillah   ◽  
Seung‐Bok Choi ◽  
Siti Aishah Abdul Aziz ◽  
...  

Author(s):  
Jussi T. Koivumäki ◽  
Jouni Takalo ◽  
Topi Korhonen ◽  
Pasi Tavi ◽  
Matti Weckström

When developing large-scale mathematical models of physiology, some reduction in complexity is necessarily required to maintain computational efficiency. A prime example of such an intricate cell is the cardiac myocyte. For the predictive power of the cardiomyocyte models, it is vital to accurately describe the calcium transport mechanisms, since they essentially link the electrical activation to contractility. The removal of calcium from the cytoplasm takes place mainly by the Na + /Ca 2+ exchanger, and the sarcoplasmic reticulum Ca 2+ ATPase (SERCA). In the present study, we review the properties of SERCA, its frequency-dependent and β -adrenergic regulation, and the approaches of mathematical modelling that have been used to investigate its function. Furthermore, we present novel theoretical considerations that might prove useful for the elucidation of the role of SERCA in cardiac function, achieving a reduction in model complexity, but at the same time retaining the central aspects of its function. Our results indicate that to faithfully predict the physiological properties of SERCA, we should take into account the calcium-buffering effect and reversible function of the pump. This ‘uncomplicated’ modelling approach could be useful to other similar transport mechanisms as well.


2020 ◽  
Vol ahead-of-print (0) ◽  
pp. 1-21
Author(s):  
Madeleine Kirstein ◽  
Mathias Schaefer ◽  
Tanja Schnittfinke ◽  
Stefan Greiving ◽  
Rouven Küsters

In order to reveal the present and future flooding impacts on residential and mixed-use areas, a parallel modelling approach (PMA) was carried out. With the use of geo-information systems (GIS), temporal and spatial impacts can be quantified and visualised, while the results of the proposed method justify adequate regional planning strategies for the Ruhr, Germany. As an information system which is regularly updated within a cooperation process between the municipalities concerned, the so called ruhrFISְ of the Ruhr Regional Association (RVR) seems to be a promising approach to improve the evidence basis for adaptation actions.


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