Vaccination of natural reservoir hosts with recombinant lipidated OspA induces a transmission-blocking immunity against Lyme disease spirochaetes associated with high levels of LA-2 equivalent antibodies

Vaccine ◽  
1997 ◽  
Vol 15 (15) ◽  
pp. 1670-1674 ◽  
Author(s):  
Klaus Kurtenbach ◽  
Astrid Dizij ◽  
Pierre Voet ◽  
Pierre Hauser ◽  
Markus M. Simon
Keyword(s):  
Lyme Disease ◽  
Transmission Blocking ◽  
Natural Reservoir ◽  
Reservoir Hosts

scholarly journals Relative incompetence of European rabbits for Lyme disease spirochaetes

Parasitology ◽  
2000 ◽  
Vol 121 (3) ◽  
pp. 297-302 ◽  
Author(s):  
F.-R. MATUSCHKA ◽  
T. W. SCHINKEL ◽  
B. KLUG ◽  
A. SPIELMAN ◽  
D. RICHTER
Keyword(s):  
Lyme Disease ◽  
Antibody Response ◽  
Ixodes Ricinus ◽  
Borrelia Afzelii ◽  
European Rabbits ◽  
Reservoir Hosts

To determine whether rabbits may serve as reservoir hosts for Lyme disease spirochaetes in Europe, we compared their competence as hosts for Borrelia afzelii, one of the most prevalent European spirochaetal variants, with that of the Mongolian jird. To infect rabbits or jirds, at least 3 nymphal or adult Ixodes ricinus ticks infected with spirochaetes fed to repletion on each animal. Whereas jirds readily acquired tick-borne Lyme disease spirochaetes and subsequently infected vector ticks, rabbits exposed to tick-borne spirochaetes rarely became infectious to ticks. Only the rabbit that was infectious to ticks developed an antibody response. To the extent that I. ricinus ticks feed on European rabbits, these mammals may be zooprophylactic by diverting vector ticks from more suitable reservoir competent hosts.

Capacity of European Animals as Reservoir Hosts for the Lyme Disease Spirochete

1992 ◽  
Vol 165 (3) ◽  
pp. 479-483 ◽  
Author(s):  
F.-R. Matuschka ◽  
P. Fischer ◽  
M. Heiler ◽  
D. Richter ◽  
A. Spielman
Keyword(s):  
Lyme Disease ◽  
Reservoir Hosts

scholarly journals How to find natural reservoir hosts from endemic prevalence in a multi-host population: A case study of influenza in waterfowl

Epidemics ◽  
2009 ◽  
Vol 1 (2) ◽  
pp. 118-128 ◽  
Author(s):  
Hiroshi Nishiura ◽  
Bethany Hoye ◽  
Marcel Klaassen ◽  
Silke Bauer ◽  
Hans Heesterbeek
Keyword(s):  
Host Population ◽  
Natural Reservoir ◽  
Reservoir Hosts

scholarly journals Adaptation of Diverse Lyme Disease Spirochetes in a Natural Rodent Reservoir Host

2004 ◽  
Vol 72 (4) ◽  
pp. 2442-2444 ◽  
Author(s):  
Dania Richter ◽  
Birte Klug ◽  
Andrew Spielman ◽  
Franz-Rainer Matuschka
Keyword(s):  
Lyme Disease ◽  
Incubation Period ◽  
Sensu Stricto ◽  
Reservoir Host ◽  
Borrelia Afzelii ◽  
Wood Mice ◽  
Reservoir Hosts

ABSTRACT We compared the relative reservoir competence of European wood mice for two genospecies of Lyme disease spirochetes by analyzing susceptibility, intrinsic incubation period, and degree and duration of infectivity. Borrelia afzelii, specializing in particular reservoir hosts, is better adapted to those hosts than is the more generalist genospecies B. burgdorferi sensu stricto.

scholarly journals Seasonal Prevalence of Lyme Disease Spirochetes in a Heterothermic Mammal, the Edible Dormouse (Glis glis)

2014 ◽  
Vol 80 (12) ◽  
pp. 3615-3621 ◽  
Author(s):  
Joanna Fietz ◽  
Jürgen Tomiuk ◽  
Franz-Rainer Matuschka ◽  
Dania Richter
Keyword(s):  
Lyme Disease ◽  
Reservoir Host ◽  
Glis Glis ◽  
Content Type ◽  
Transmission Cycle ◽  
Western Germany ◽  
Edible Dormice ◽  
Study Sites ◽  
Reservoir Hosts

ABSTRACTIn Europe, dormice serve as competent reservoir hosts for particular genospecies of the tick-borne agent of Lyme disease (LD) and seem to support them more efficiently than do mice or voles. The longevity of edible dormice (Glis glis) and their attractiveness for ticks may result in a predominance of LD spirochetes in ticks questing in dormouse habitats. To investigate the role of edible dormice in the transmission cycle of LD spirochetes, we sampled skin tissue from the ear pinnae of dormice inhabiting five different study sites in south western Germany. Of 501 edible dormice, 12.6% harbored DNA of LD spirochetes. Edible dormice were infected most frequently with the pathogenic LD spirocheteBorrelia afzelii. The DNA ofB. gariniiandB. bavariensiswas detected in ca. 0.5% of the examined individuals. No spirochetal DNA was detectable in the skin of edible dormice until July, 6 weeks after they generally start to emerge from their obligate hibernation. Thereafter, the prevalence of spirochetal DNA in edible dormice increased during the remaining period of their 4 to 5 months of activity, reaching nearly 40% in September. Males were more than four times more likely to harbor LD spirochetes than females, and yearlings were almost twice more likely to be infected than adults. The seasonality of the prevalence of LD spirochetes in edible dormice was pronounced and may affect their role as a reservoir host in respect to other hosts.

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