Differences in sensitivity of vanilloid receptor 1 transfected to human embryonic kidney cells and capsaicin-activated channels in cultured rat dorsal root ganglion neurons to capsaicin receptor agonists

2001 ◽  
Vol 299 (1-2) ◽  
pp. 135-139 ◽  
Author(s):  
Jae Soo Shin ◽  
Myeong-Hyeon Wang ◽  
Sun Wook Hwang ◽  
Hawon Cho ◽  
So Yeon Cho ◽  
...  
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Vanilloid Receptor ◽  
Dorsal Root Ganglion Neurons ◽  
Kidney Cells ◽  
Human Embryonic Kidney ◽  
Capsaicin Receptor ◽  
Human Embryonic Kidney Cells ◽  
Vanilloid Receptor 1 ◽  
Ganglion Neurons

scholarly journals Anandamide Excites Central Terminals of Dorsal Root Ganglion Neurons via Vanilloid Receptor-1 Activation

2001 ◽  
Vol 21 (4) ◽  
pp. 1104-1109 ◽  
Author(s):  
Michele Tognetto ◽  
Silvia Amadesi ◽  
Selena Harrison ◽  
Christophe Creminon ◽  
Marcello Trevisani ◽  
...  
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Vanilloid Receptor ◽  
Dorsal Root Ganglion Neurons ◽  
Vanilloid Receptor 1 ◽  
Ganglion Neurons

Co-expression of heat sensitive vanilloid receptor subtypes in rat dorsal root ganglion neurons

Neuroreport ◽  
2003 ◽  
Vol 14 (17) ◽  
pp. 2251-2255 ◽  
Author(s):  
Wolfgang Greffrath ◽  
Uta Binzen ◽  
Stefan T. Schwarz ◽  
Sigrid Saaler-Reinhardt ◽  
Rolf-Detlef Treede
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Vanilloid Receptor ◽  
Dorsal Root Ganglion Neurons ◽  
Receptor Subtypes ◽  
Ganglion Neurons

scholarly journals Versatile Regulation of Cytosolic Ca2+by Vanilloid Receptor I in Rat Dorsal Root Ganglion Neurons

2002 ◽  
Vol 278 (7) ◽  
pp. 5462-5472 ◽  
Author(s):  
Min Liu ◽  
Meng-Chuan Liu ◽  
Charalambos Magoulas ◽  
John V. Priestley ◽  
Nick J. Willmott
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Vanilloid Receptor ◽  
Dorsal Root Ganglion Neurons ◽  
Ganglion Neurons

scholarly journals Anti–contactin-1 Antibodies Affect Surface Expression and Sodium Currents in Dorsal Root Ganglia

2021 ◽  
Vol 8 (5) ◽  
pp. e1056
Author(s):  
Julia Grüner ◽  
Helena Stengel ◽  
Christian Werner ◽  
Luise Appeltshauser ◽  
Claudia Sommer ◽  
...  
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Surface Expression ◽  
Dorsal Root Ganglion Neurons ◽  
Granule Neurons ◽  
Sodium Currents ◽  
Human Embryonic Kidney ◽  
293 Cells ◽  
Ganglion Neurons

Background and ObjectivesAs autoantibodies to contactin-1 from patients with chronic inflammatory demyelinating polyradiculoneuropathy not only bind to the paranodes where they are supposed to cause conduction failure but also bind to other neuronal cell types, we aimed to investigate the effect of anti–contactin-1 autoantibodies on contactin-1 surface expression in cerebellar granule neurons, dorsal root ganglion neurons, and contactin-1–transfected human embryonic kidney 293 cells.MethodsImmunocytochemistry including structured illumination microscopy and immunoblotting was used to determine expression levels of contactin-1 and/or sodium channels after long-term exposure to autoantibodies from 3 seropositive patients. For functional analysis of sodium channels, whole-cell recordings of sodium currents were performed on dorsal root ganglion neurons incubated with anti–contactin-1 autoantibodies.ResultsWe found a reduction in contactin-1 expression levels on dorsal root ganglion neurons, cerebellar granule neurons, and contactin-1–transfected human embryonic kidney 293 cells and decreased dorsal root ganglion sodium currents after long-term exposure to anti–contactin-1 autoantibodies. Sodium channel density did not decrease.DiscussionOur results demonstrate a direct effect of anti–contactin-1 autoantibodies on the surface expression of contactin-1 and sodium currents in dorsal root ganglion neurons. This may be the pathophysiologic correlate of sensory ataxia reported in these patients.

Sign in / Sign up

Export Citation Format

Share Document