scholarly journals Comparative analysis of fatty acid amide hydrolase and cb1 cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling

Neuroscience ◽  
2003 ◽  
Vol 119 (2) ◽  
pp. 481-496 ◽  
Author(s):  
M Egertová ◽  
B.F Cravatt ◽  
M.R Elphick
Keyword(s):  
Fatty Acid ◽  
Comparative Analysis ◽  
Mouse Brain ◽  
Cannabinoid Receptor ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Receptor Expression ◽  
Cb1 Cannabinoid Receptor ◽  
Amide Hydrolase ◽  
Fatty Acid Amide

scholarly journals Marijuana withdrawal and craving: influence of the cannabinoid receptor 1 (CNR1) and fatty acid amide hydrolase (FAAH) genes

Addiction ◽  
2008 ◽  
Vol 103 (10) ◽  
pp. 1678-1686 ◽  
Author(s):  
Heather M. Haughey ◽  
Erin Marshall ◽  
Joseph P. Schacht ◽  
Ashleigh Louis ◽  
Kent E. Hutchison
Keyword(s):  
Fatty Acid ◽  
Cannabinoid Receptor ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Cannabinoid Receptor 1 ◽  
Amide Hydrolase ◽  
Fatty Acid Amide

Immunohistochemical distribution of the cannabinoid receptor 1 and fatty acid amide hydrolase in the dog claustrum

2016 ◽  
Vol 74 ◽  
pp. 21-27 ◽  
Author(s):  
Andrea Pirone ◽  
Carlo Cantile ◽  
Vincenzo Miragliotta ◽  
Carla Lenzi ◽  
Elisabetta Giannessi ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Cannabinoid Receptor ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Cannabinoid Receptor 1 ◽  
Amide Hydrolase ◽  
Fatty Acid Amide

Endocannabinoid System: Overview and Therapeutic Relevance

2021 ◽  
Author(s):  
Alex Mabou Tagne
Keyword(s):  
Fatty Acid ◽  
Cannabinoid Receptors ◽  
Cannabinoid Receptor ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Endocannabinoid System ◽  
Receptor Subtypes ◽  
Monoacylglycerol Lipase ◽  
Amide Hydrolase ◽  
Fatty Acid Amide

The endocannabinoid system (ECS) modulates a variety of physiological processes, attracting considerable attention as a potential target for therapeutic intervention. This complex system is activated by the lipid-derived mediators anandamide and 2-arachidonoyl-sn-glycerol (2-AG), which mainly engage the cannabinoid receptor subtypes 1 (CB1) and 2 (CB2). The biological actions of anandamide and 2-AG are terminated by internalization and intracellular enzymatic hydrolysis catalyzed primarily by the serine hydrolases fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGL), respectively. Here, we provide an overview of ECS and discuss the implications for advancing pharmacological tools that interfere with such a system as next-generation therapeutics. This review contains 4 figures, 3 tables and 41 references Keywords: Endocannabinoid; anandamide; 2-Arachidonoyl-sn-glycerol; fatty acid amide hydrolase; monoacylglycerol lipase; cannabinoid receptors; N-acylethanolamine acid amidase; Δ9-tetrahydrocannabinol.

Sign in / Sign up

Export Citation Format

Share Document