Iron-regulated outer membrane proteins of Pasteurella multocida and their role in immunity

1998 ◽  
Vol 59 (2-3) ◽  
pp. 123-137 ◽  
Author(s):  
Carmel G. Ruffolo ◽  
B. Helen Jost ◽  
Ben Adler
Keyword(s):  
Membrane Proteins ◽  
Outer Membrane ◽  
Pasteurella Multocida ◽  
Outer Membrane Proteins

scholarly journals Differences between Predicted Outer Membrane Proteins of Pasteurella multocida, Histophilus somni, and Genotype 1 and 2 Mannheimia haemolytica Strains Isolated from Cattle

Genome ◽  
2021 ◽  
Author(s):  
Emily L Wynn ◽  
Michael Clawson
Keyword(s):  
Membrane Proteins ◽  
Outer Membrane ◽  
Pasteurella Multocida ◽  
Outer Membrane Proteins ◽  
Host Immunity ◽  
Mannheimia Haemolytica ◽  
Genotype 1 ◽  
The Core ◽  
Histophilus Somni ◽  
Genotype 2

Common bacterial causes of bovine respiratory disease (BRD) include Histophilus somni, Mannheimia haemolytica, and Pasteurella multocida. Within M. haemolytica, two major genotypes are commonly found in cattle (1 and 2), however, genotype 2 strains are isolated from diseased lungs much more frequently than genotype 1 strains. Outer membrane proteins (OMPs) of H. somni, P. multocida, and genotype 2 M. haemolytica may be important factors for acquired host immunity. Predicted OMP differences between genotype 1 and 2 M. haemolytica have been previously identified. In this study, we expanded that focus to include bovine-isolated strain genomes representing all three species and the two M. haemolytica genotypes. Reported here are the core genomes unique to each of them, core genomes shared between some or all combinations of the three species and two M. haemolytica genotypes, and predicted OMPs within these core genomes. The OMPs identified in this study are potential candidates for further study and the development of interventions against BRD.

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