Nuclear medicine: diagnosis and therapy. C.

1996 ◽  
Vol 23 (3) ◽  
pp. 253
Keyword(s):  
Nuclear Medicine ◽  
Diagnosis And Therapy

Molecular imaging and molecular guided Therapy

2006 ◽  
Vol 45 (06) ◽  
pp. 273-276
Author(s):  
A. Jigalin ◽  
H. Lerch
Keyword(s):  
Nuclear Medicine ◽  
Molecular Imaging ◽  
Functional Imaging ◽  
Therapy Planning ◽  
Scientific Publications ◽  
Diagnosis And Therapy ◽  
Guided Therapy

SummaryAim and method: Scientific publications in the journal of Nuklearmedizin Molecular Imaging and Therapy during 2004/2005 were retrospectively examined for their potential classification to molecular imaging or molecular guided therapy, functional imaging and therapy, and were compared to earlier analyses. Results: Of the 57 original papers examined, 36 (63%) were assigned to the category of molecular imaging / molecular guided therapy. Within this category, the number of original papers on molecular guided therapy increased by 19% compared to preceding periods. There was a general overall increase in the proportion of experimental papers and more frequent inclusion of basic background subjects. Conclusion: The development of molecular imaging as a direct instrument in therapy planning leads to further promotion of molecular guided therapy. The structural advantage of nuclear medicine, uniting method-lead diagnosis and therapy within one specialist subject, predestines it to advance molecular imaging and molecular guided therapy.

Nuclear Medicine: Diagnosis and Therapy

Radiology ◽  
1997 ◽  
Vol 204 (3) ◽  
pp. 738-738
Author(s):  
Mitchel M. S. Kim
Keyword(s):  
Nuclear Medicine ◽  
Diagnosis And Therapy

Nuclear medicine in cancer diagnosis and therapy

2017 ◽  
Author(s):  
V. Chernov ◽  
R. Zeltchan ◽  
A. Medvedeva ◽  
I. Sinilkin ◽  
O. Bragina
Keyword(s):  
Nuclear Medicine ◽  
Cancer Diagnosis ◽  
Diagnosis And Therapy ◽  
Cancer Diagnosis And Therapy

The Influence of Different Spacers on Biological Profile of Peptide Radiopharmaceuticals for Diagnosis and Therapy of Human Cancers

2020 ◽  
Vol 20 (4) ◽  
pp. 402-416 ◽  
Author(s):  
Arezou M. Farahani ◽  
Fariba Maleki ◽  
Nourollah Sadeghzadeh
Keyword(s):  
Nuclear Medicine ◽  
Hydrocarbon Chain ◽  
Total Charge ◽  
Liver Uptake ◽  
Radiolabeled Peptides ◽  
Normal Tissues ◽  
Diagnosis And Therapy ◽  
Specificity And Sensitivity

Background: Cancer is the leading cause of death worldwide. Early detection can reduce the disadvantageous effects of diseases and the mortality in cancer. Nuclear medicine is a powerful tool that has the ability to diagnose malignancy without harming normal tissues. In recent years, radiolabeled peptides have been investigated as potent agents for cancer detection. Therefore, it is necessary to modify radiopeptides in order to achieve more effective agents. Objective: This review describes modifications in the structure of radioconjugates with spacers who have improved the specificity and sensitivity of the peptides that are used in oncologic diagnosis and therapy. Methods: To improve the biological activity, researchers have conjugated these peptide analogs to different spacers and bifunctional chelators. Many spacers of different kinds, such as hydrocarbon chain, amino acid sequence, and poly (ethyleneglycol) were introduced in order to modify the pharmacokinetic properties of these biomolecules. Results: Different spacers have been applied to develop radiolabeled peptides as potential tracers in nuclear medicine. Spacers with different charge and hydrophilicity affect the characteristics of peptide conjugate. For example, the complex with uncharged and hydrophobic spacers leads to increased liver uptake, while the composition with positively charged spacers results in high kidney retention. Therefore, the pharmacokinetics of radio complexes correlates to the structure and total charge of the conjugates. Conclusion: Radio imaging technology has been successfully applied to detect a tumor in the earliest stage. For this purpose, the assessment of useful agents to diagnose the lesion is necessary. Developing peptide radiopharmaceuticals using spacers can improve in vitro and in vivo behavior of radiotracers leading to better noninvasive detection and monitoring of tumor growth.

Nuclear medicine: diagnosis and therapy

1996 ◽  
Vol 31 (2) ◽  
pp. 96-100
Author(s):  
Ann Dixon-Brown ◽  
Nigel D W Soper
Keyword(s):  
Nuclear Medicine ◽  
Diagnosis And Therapy
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