Quantification of Myocardial Blood Flow and Flow Reserve in Children With a History of Kawasaki Disease and Normal Coronary Arteries Using Positron Emission Tomography

1996 ◽  
Vol 28 (3) ◽  
pp. 757-762 ◽  
Author(s):  
O Muzik, PhD
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Kawasaki Disease ◽  
Myocardial Blood Flow ◽  
Coronary Arteries ◽  
Emission Tomography ◽  
Normal Coronary Arteries ◽  
Flow Reserve ◽  
Positron Emission ◽  
History Of

scholarly journals Improved regional myocardial blood flow and flow reserve after coronary revascularization as assessed by serial 15O-water positron emission tomography/computed tomography

2019 ◽  
Vol 21 (1) ◽  
pp. 36-46 ◽  
Author(s):  
Tadao Aikawa ◽  
Masanao Naya ◽  
Kazuhiro Koyanagawa ◽  
Osamu Manabe ◽  
Masahiko Obara ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Coronary Artery ◽  
Myocardial Blood Flow ◽  
Coronary Revascularization ◽  
Emission Tomography ◽  
Regional Stress ◽  
Flow Reserve ◽  
Positron Emission ◽  
Stable Cad

Abstract Aims Myocardial perfusion imaging without and with quantitative myocardial blood flow (MBF) and myocardial flow reserve (MFR) plays an important role in the diagnosis and risk stratification of patients with stable coronary artery disease (CAD). We aimed to quantify the effects of coronary revascularization on regional stress MBF and MFR and to determine whether the presence of subendocardial infarction was associated with these changes. Methods and results Forty-seven patients with stable CAD were prospectively enrolled. They underwent 15O-water positron emission tomography at baseline and 6 months after optimal medical therapy alone (n = 16), percutaneous coronary intervention (PCI) (n = 18), or coronary artery bypass grafting (CABG) (n = 13). Stenosis of ≥50% diameter was detected in 98/141 vessels (70%). The regional MFR was significantly increased from baseline to follow-up [1.84 (interquartile range, IQR 1.28–2.17) vs. 2.12 (IQR 1.69–2.63), P < 0.001] in vessel territories following PCI or CABG due to an increase in the stress MBF [1.33 (IQR 0.97–1.67) mL/g/min vs. 1.64 (IQR 1.38–2.17) mL/g/min, P < 0.001], whereas there was no significant change in the regional stress MBF or MFR in vessel territories without revascularization. A multilevel mixed-effects models adjusted for baseline characteristics, subendocardial infarction assessed by cardiovascular magnetic resonance imaging, and intra-patient correlation showed that the degree of angiographic improvement after coronary revascularization was significantly associated with increased regional stress MBF and MFR (P < 0.05 for all). Conclusion Coronary revascularization improved the regional stress MBF and MFR in patients with stable CAD. The magnitude of these changes was associated with the extent of revascularization independent of subendocardial infarction.

scholarly journals Positron emission tomography application for myocardial blood flow and coronary flow reserve measurement in patients with cardiovascular pathology

2006 ◽  
Vol 12 (3) ◽  
pp. 200-211 ◽  
Author(s):  
D. V. Ryzhkova ◽  
E. M. Nifontov ◽  
L. A. Tyutin
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Coronary Flow Reserve ◽  
Coronary Flow ◽  
Emission Tomography ◽  
Idiopathic Dilated Cardiomyopathy ◽  
Cardiovascular Pathology ◽  
Flow Reserve ◽  
Positron Emission

This article summarizes data of the studies with positron emission tomography (PET) and devotes the clinical application of PET for myocardial blood flow and coronary flow reserve measurement in the patients with cardiovascular pathology. Measurement of myocardial blood flow and coronary flow reserve allows to assess the functional importance of coronary stenosis in patients with coronary heart disease. According the results of experimental and clinical studies the impairment of coronary vasomotor reactivity seems to be the main cause of coronary microcirculatory abnormalities in the patients with high risk of cardiovascular diseases. Noninvasive PET diagnostics of myocardial blood flow provides the valuable information for stratification of the risk of the severe cardiovascular complications. PET seems to be a good tool for assessment of the medical treatment efficiency of arterial hypertension, diabetes mellitus, hypercholesterolemia and hypoestrogenemia. Myocardial blood flow impairment is independent prognostic marker of future adverse cardiac events and sudden cardiac death in patients with hypertrophic cardiomyopathy and idiopathic dilated cardiomyopathy.

scholarly journals Vitamin D Status and Coronary Flow Reserve Measured by Positron Emission Tomography: A Co-Twin Control Study

2013 ◽  
Vol 98 (1) ◽  
pp. 389-397 ◽  
Author(s):  
Cristina Karohl ◽  
Viola Vaccarino ◽  
Emir Veledar ◽  
Jack Goldberg ◽  
Vin Tangpricha ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Vitamin D ◽  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Coronary Flow ◽  
Vitamin D Insufficiency ◽  
Emission Tomography ◽  
Vitamin D Status ◽  
Flow Reserve ◽  
Positron Emission

Abstract Context: Vitamin D insufficiency is associated with increased cardiovascular events in the general population. Additionally, low serum 25-hydroxyvitamin D [25(OH)D] is associated with endothelial dysfunction and arterial stiffness. However, little is known about the association between serum 25(OH)D level and myocardial blood flow. Objective: Our objective was to examine the association between serum 25(OH)D levels and coronary flow reserve (CFR) measured by 13N-positron emission tomography in asymptomatic middle-aged male twins. Design: The Emory Twin Study is a cross-sectional study of soldiers from the Vietnam Era Registry. Setting: The study was conducted at the General Clinical Research Center, Emory University, Atlanta, GA. Participants: A total of 368 middle-aged male twins were enrolled for the study. Serum 25(OH)D levels were measured in all subjects and classified as vitamin D insufficiency [25(OH)D <30 ng/ml] or sufficiency [25(OH)D ≥30 ng/ml]. Positron emission tomography with [13N]ammonia was used to evaluate myocardial blood flow at rest and after adenosine stress. CFR was measured as the ratio of maximum to rest myocardial blood flow. Main Outcome Measure: Primary outcome was CFR measurement. Results: Mean overall serum 25(OH)D concentration was 37.0 ± 21.4 ng/ml; 167 twins (45%) were vitamin D insufficient. CFR was significantly lower in subjects with vitamin D insufficiency compared with subjects with vitamin D sufficiency (2.41 vs. 2.64; P = 0.007), even after adjustment for traditional cardiovascular risk factors, serum PTH, calcium, and phosphorus levels, and season. An abnormal CFR (CFR <2) was more prevalent in subjects with vitamin D insufficiency than with vitamin D sufficiency (31 vs. 20%; P = 0.03). In addition, in vitamin D status-discordant twin pairs, CFR was significantly lower in the vitamin D-insufficient twin than in the vitamin D-sufficient co-twin (2.35 vs. 2.58; P = 0.037). Conclusion: Vitamin D insufficiency is associated with lower CFR in men. This association may help explain some of the increased cardiovascular risk reported in individuals with vitamin D insufficiency.

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