Perioperative Airway Evaluation during Cleft Palate Repair at an Early Age in Infants and Children with Pierre Robin Sequence

2005 ◽  
Vol 17 (2) ◽  
pp. 104-108
Author(s):  
Lian Zhou ◽  
Lian Ma ◽  
Rui-Chang Liu ◽  
Ke-Ying Liu ◽  
Xing Wang
Keyword(s):  
Cleft Palate ◽  
Infants And Children ◽  
Early Age ◽  
Pierre Robin Sequence ◽  
Robin Sequence ◽  
Cleft Palate Repair ◽  
Palate Repair ◽  
Pierre Robin ◽  
In Infants And Children

Clinical Outcomes of the Furlow Z-Plasty for Primary Cleft Palate Repair

2008 ◽  
Vol 45 (5) ◽  
pp. 501-510 ◽  
Author(s):  
Rohit K. Khosla ◽  
Kelly Mabry ◽  
Charles L. Castiglione
Keyword(s):  
Cleft Palate ◽  
Clinical Outcomes ◽  
Velopharyngeal Insufficiency ◽  
Fistula Formation ◽  
Pierre Robin Sequence ◽  
Robin Sequence ◽  
Surgeon Experience ◽  
Cleft Palate Repair ◽  
Palate Repair ◽  
Pierre Robin

Objective: To review the clinical outcomes following the Furlow Z-plasty for primary cleft palate repair. The primary objective was to determine if the presence of an associated sequence or syndrome (i.e., Pierre Robin sequence), age at palate repair, cleft type, or surgeon experience influenced speech outcomes after a Furlow Z-plasty. Design: The outcomes of 140 patients who underwent palate repair were analyzed retrospectively. Speech evaluations were performed to score the severity of hypernasality, nasal escape, articulation errors, and velopharyngeal insufficiency. Results: The mean age at latest evaluation was 4 years 9 months (age range 2 years old to 12 years old and 4 months). Of the 140 patients, 83% had no evidence of hypernasality, 91% had no presence of nasal escape, and 69% had no articulation errors. Overall, 84% of patients had no evidence of velopharyngeal insufficiency. Secondary posterior pharyngeal flap to correct velopharyngeal insufficiency was required in only 2.1% of patients. The formation of an oronasal fistula occurred in only 3.6% of patients. Nonsyndromic patients with Pierre Robin sequence and syndromic patients did just as well as purely nonsyndromic patients in terms of velopharyngeal insufficiency, hypernasality, and nasal escape. Syndromic patients were more likely to make mild-to-moderate articulation errors. In addition, age at palate repair, cleft type, and surgeon experience had no statistically significant effect on speech results. Conclusions: The Furlow Z-plasty yielded excellent speech results in our patient population with minimal and acceptable rates of fistula formation, velopharyngeal insufficiency, and the need for additional corrective surgery.

Outcomes of Cleft Palate Repair in Patients with Pierre Robin Sequence

2016 ◽  
Vol 137 (3) ◽  
pp. 927-935 ◽  
Author(s):  
Joseph T. Hardwicke ◽  
Helen Richards ◽  
Louise Cafferky ◽  
Imogen Underwood ◽  
Britt ter Horst ◽  
...  
Keyword(s):  
Cleft Palate ◽  
Pierre Robin Sequence ◽  
Robin Sequence ◽  
Cleft Palate Repair ◽  
Palate Repair ◽  
Pierre Robin

scholarly journals Long-term Speech Outcomes of Cleft Palate Repair in Robin Sequence versus Isolated Cleft Palate

2021 ◽  
Vol 9 (1) ◽  
pp. e3351
Author(s):  
Robrecht J. H. Logjes ◽  
Susanna Upton ◽  
Bryce A. Mendelsohn ◽  
Ryan K. Badiee ◽  
Corstiaan C. Breugem ◽  
...  
Keyword(s):  
Cleft Palate ◽  
Robin Sequence ◽  
Sequence Versus ◽  
Cleft Palate Repair ◽  
Palate Repair ◽  
Isolated Cleft Palate

scholarly journals Methadone, Pierre Robin sequence and other congenital anomalies: case–control study

2019 ◽  
Vol 105 (2) ◽  
pp. 151-157
Author(s):  
Brian Cleary ◽  
Maria Loane ◽  
Marie-Claude Addor ◽  
Ingeborg Barisic ◽  
Hermien E K de Walle ◽  
...  
Keyword(s):  
Cleft Palate ◽  
Congenital Anomalies ◽  
Population Based ◽  
Pierre Robin Sequence ◽  
Opioid Use ◽  
Robin Sequence ◽  
Risk Increase ◽  
Increased Risk ◽  
Pierre Robin ◽  
Control Study

ObjectiveMethadone is a vital treatment for women with opioid use disorder in pregnancy. Previous reports suggested an association between methadone exposure and Pierre Robin sequence (PRS), a rare craniofacial anomaly. We assessed the association between gestational methadone exposure and PRS.Design/settingThis case-malformed control study used European Surveillance of Congenital Anomalies population-based registries in Ireland, the Netherlands, Italy, Switzerland, Croatia, Malta, Portugal, Germany, Wales, Norway and Spain, 1995–2011.PatientsCases included PRS based on International Classification of Disease (ICD), Ninth Edition-British Paediatric Association (BPA) code 75 603 or ICD, Tenth Edition-BPA code Q8708. Malformed controls were all non-PRS anomalies, excluding genetic conditions, among live births, fetal deaths from 20 weeks’ gestation and terminations of pregnancy for fetal anomalies. An exploratory analysis assessed the association between methadone exposure and other congenital anomalies (CAs) excluding PRS. Methadone exposure was ascertained from medical records and maternal interview.ResultsAmong 87 979 CA registrations, there were 127 methadone-exposed pregnancies and 336 PRS cases. There was an association between methadone exposure and PRS (OR adjusted for registry 12.3, 95% CI 5.7 to 26.8). In absolute terms, this association reflects a risk increase from approximately 1–12 cases per 10 000 births. A raised OR was found for cleft palate (adjusted OR 5.0, 95% CI 2.7 to 9.2).ConclusionsThese findings suggest that gestational methadone exposure is associated with PRS. The association may be explained by unmeasured confounding factors. The small increased risk of PRS in itself does not alter the risk–benefit balance for gestational methadone use. The association with cleft palate, a more common CA, should be assessed with independent data.

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