Alterations in electrical and mechanical activity in Langendorff-perfused guinea pig hearts exposed to decreased external sodium concentration with or without hypotonic insult

2001 ◽  
Vol 7 (4) ◽  
pp. 251-261 ◽  
Author(s):  
Nobuhito Yanagi ◽  
Toru Maruyama ◽  
Makoto Arita ◽  
Yoshikazu Kaji ◽  
Yoshiyuki Niho
Keyword(s):  
Guinea Pig ◽  
Sodium Concentration ◽  
Mechanical Activity

Endogenous prostaglandin in guinea pig taenia coli

1976 ◽  
Vol 230 (1) ◽  
pp. 149-157 ◽  
Author(s):  
T Yamaguchi ◽  
B Hitzig ◽  
RF Coburn
Keyword(s):  
Guinea Pig ◽  
Surface Membrane ◽  
Membrane Resistance ◽  
Threshold Concentration ◽  
Mechanical Activity ◽  
Taenia Coli ◽  
Endogenous Prostaglandin ◽  
Sucrose Gap ◽  
Spontaneous Action ◽  
Spontaneous Action Potentials

Prostaglandin (PGE) is synthesized in the guinea pig taenia coli. A low threshold concentration for an effect of exogenous PGE1 or PGE2 on spontaneous mechanical activity was demonstrated. The PG synthetase inhibitors aspirin, indomethacin, and 5,8,11,14-eicosatetraynoic acid, at concentrations that inhibited PGE efflux, had effects on spontaneous mechanical activity, membrane potential, membrane resistance, and evoked and spontaneous action potentials (single and double sucrose-gap methods) that were consistent with an action due to inhibition of membrane PGE concentration. The threshold concentration of indomethacin, which inhibited PGE efflux, was the same as the concentration that inhibited spontaneous mechanical activity. Pretreatment with ouabain (10(-6)-10(-5) g/ml) or elevated extracellular K+ (29 and 126 mM) made the guinea pig taenia coli entirely refractory to exogenous PGE1 or PGE2; the mechanical effects of the three prostaglandin synthetase inhibitors also were absent in the presence of elevated K+ or ouabain. The data are consistent with a hypothesis that, under conditions of our experiments, endogenous PGE has an effect on resting tension and spontaneous mechanical activity and on properties of the surface membrane of the guinea pig taenia coli.

Effect of sodium concentration and of atropine on the contractile response of the guinea-pig ileum to potassium ions

1982 ◽  
Vol 394 (2) ◽  
pp. 186-190 ◽  
Author(s):  
Suma I. Shimuta ◽  
Viviane L. A. Nouailhetas ◽  
Valderez B. Valero ◽  
Antonio C. M. Paiva ◽  
Therezinha B. Paiva
Keyword(s):  
Guinea Pig ◽  
Contractile Response ◽  
Sodium Concentration ◽  
Potassium Ions ◽  
Guinea Pig Ileum

scholarly journals Modification by charybdotoxin and apamin of spontaneous electrical and mechanical activity of the circular smooth muscle of the guinea-pig stomach

1993 ◽  
Vol 109 (3) ◽  
pp. 661-666 ◽  
Author(s):  
Keiko Suzuki ◽  
Kaoru M. Ito ◽  
Yukie Minayoshi ◽  
Hikaru Suzuki ◽  
Masahisa Asano ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Mechanical Activity ◽  
Circular Smooth Muscle ◽  
Guinea Pig Stomach
Sign in / Sign up

Export Citation Format

Share Document