Quality of life and survival in patients with advanced non-small cell lung cancer receiving supportive care plus chemotherapy with carboplatin and etoposide or supportive care only. A multicentre randomised phase III trial

1998 ◽  
Vol 34 (7) ◽  
pp. 1036-1044 ◽  
Author(s):  
M Helsing ◽  
B Bergman ◽  
L Thaning ◽  
U Hero
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Supportive Care ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Phase Iii ◽  
Small Cell Lung ◽  
Phase Iii Trial

scholarly journals WEEKLY ASSESSMENT OF QUALITY OF LIFE IN PATIENTS WITH ADVANCED NON-SMALL-CELL LUNG CANCER DURING CHEMOTHERAPY IN A RANDOMIZED PHASE III TRIAL

2004 ◽  
Vol 12 (1/2) ◽  
pp. 105-117
Author(s):  
Satoshi Morita ◽  
Kunihiko Kobayashi ◽  
Yasuo Ohashi ◽  
Kenji Eguchi ◽  
Masahiko Shibuya ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Phase Iii ◽  
Small Cell Lung ◽  
Phase Iii Trial ◽  
Weekly Assessment

scholarly journals Feasibility of quality of life assessment in a randomized phase III trial of small cell lung cancer

1992 ◽  
Vol 3 (10) ◽  
pp. 825-831 ◽  
Author(s):  
C. Hürny ◽  
J. Bernhard ◽  
R. Joss ◽  
Y. Willems ◽  
F. Cavalli ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Small Cell ◽  
Life Assessment ◽  
Phase Iii ◽  
Small Cell Lung ◽  
Quality Of Life Assessment ◽  
Phase Iii Trial

Phase III Trial Comparing Supportive Care Alone With Supportive Care With Oral Topotecan in Patients With Relapsed Small-Cell Lung Cancer

2006 ◽  
Vol 24 (34) ◽  
pp. 5441-5447 ◽  
Author(s):  
Mary E.R. O'Brien ◽  
Tudor-Eliade Ciuleanu ◽  
Hristo Tsekov ◽  
Yaroslav Shparyk ◽  
Branka Čučeviá ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Supportive Care ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Grade 3 ◽  
Oral Topotecan

Purpose For patients with small-cell lung cancer (SCLC), further chemotherapy is routinely considered at relapse after first-line therapy. However, proof of clinical benefit has not been documented. Patients and Methods This study randomly assigned patients with relapsed SCLC not considered as candidates for standard intravenous therapy to best supportive care (BSC) alone (n = 70) or oral topotecan (2.3 mg/m2/d, days 1 through 5, every 21 days) plus BSC (topotecan; n = 71). Results In the intent-to-treat population, survival (primary end point) was prolonged in the topotecan group (log-rank P = .0104). Median survival with BSC was 13.9 weeks (95% CI, 11.1 to 18.6) and with topotecan, 25.9 weeks (95% CI, 18.3 to 31.6). Statistical significance for survival was maintained in a subgroup of patients with a short treatment-free interval (≤ 60 days). Response to topotecan was 7% partial and 44% stable disease. Patients on topotecan had slower quality of life deterioration and greater symptom control. Principal toxicities with topotecan were hematological: grade 4 neutropenia, 33%; grade 4 thrombocytopenia, 7%; and grade 3/4 anemia, 25%. Comparing topotecan with BSC, infection ≥ grade 2 was 14% versus 12% and sepsis 4% versus 1%; other grade 3/4 events included vomiting 3% versus 0, diarrhea 6% versus 0, dyspnea 3% versus 9%, and pain 3% versus 6%. Toxic deaths occurred in four patients (6%) in the topotecan arm. All cause mortality within 30 days of random assignment was 13% on BSC and 7% on topotecan. Conclusion Chemotherapy with oral topotecan is associated with prolongation of survival and quality of life benefit in patients with relapsed SCLC.

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