Tissue-specific expression of the human CYP19 (aromatase) gene in ovary and adipose tissue of transgenic mice

2001 ◽  
Vol 79 (1-5) ◽  
pp. 193-201 ◽  
Author(s):  
Margaret M Hinshelwood ◽  
Carole R Mendelson
1992 ◽  
Vol 20 (9) ◽  
pp. 2249-2255 ◽  
Author(s):  
Thomas R. Mikkelsen ◽  
Jakob Brandt ◽  
H.Jakob Larsen ◽  
Birte B. Larsen ◽  
Knud Poulsen ◽  
...  

Cell ◽  
1984 ◽  
Vol 38 (3) ◽  
pp. 639-646 ◽  
Author(s):  
Galvin H. Swift ◽  
Robert E. Hammer ◽  
Raymond J. MacDonald ◽  
Ralph L. Brinster

1995 ◽  
Vol 4 (3) ◽  
pp. 359-366 ◽  
Author(s):  
Martin Hergersberg ◽  
Koichi Matsuo ◽  
Max Gassmann ◽  
Walter Schaffner ◽  
Bernhard Lüscher ◽  
...  

1989 ◽  
Vol 186 (1-2) ◽  
pp. 43-48 ◽  
Author(s):  
Jean-Luc VILOTTE ◽  
Solange SOULIER ◽  
Marie-George STINNAKRE ◽  
Micheline MASSOUD ◽  
Jean-Claude MERCIER

1988 ◽  
Vol 16 (3) ◽  
pp. 1027-1041 ◽  
Author(s):  
Kuo-Fen Lee ◽  
Francesco J. DeMayo ◽  
Suzanne H. Atiee ◽  
Jeffrey M. Rosen

2004 ◽  
Vol 17 (1) ◽  
pp. 4-10 ◽  
Author(s):  
Ravi Nistala ◽  
Xiaoji Zhang ◽  
Curt D. Sigmund

We previously reported the development and characterization of transgenic mice containing a large 160-kb P1 artificial chromosome (PAC) encompassing the renin (REN) locus from human chromosome 1. Here we demonstrate that PAC160 not only encodes REN, but also complete copies of the next upstream (KISS1) and downstream ( FLJ10761 ) gene along human chromosome 1. Incomplete copies of the second upstream (PEPP3) and downstream (SOX13) genes are also present. The gene order PEPP3-KISS1-REN-FLJ10761-SOX13 is conserved in mice containing either one or two copies of the REN locus. Despite the close localization of KISS1, REN, and FLJ10761 , they each exhibit distinct, yet overlapping tissue-specific expression profiles in humans. The tissue-specific expression patterns of REN and FLJ10761 were retained in transgenic mice containing PAC160. Expression of REN and FLJ10761 were also proportional to copy number. Expression of KISS1 in PAC160 mice showed both similarities and differences to humans. These data suggest that expression of gene blocks encoded on large genomic clones are retained when the clones are used to generate transgenic mice. Genomic elements which act to insulate genes from their neighbors are also apparently retained.


2020 ◽  
Vol 68 (7) ◽  
pp. 2256-2262
Author(s):  
Miao Ji ◽  
Ke Xu ◽  
Dawei Zhang ◽  
Tingting Chen ◽  
Liangcai Shen ◽  
...  

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