Synthesis and incorporation of methyleneoxy(methylimino) linked thymidine dimer into antisense oligonucleosides

1992 ◽  
Vol 2 (12) ◽  
pp. 1479-1482 ◽  
Author(s):  
Françoise Debart ◽  
Jean-Jacques Vasseur ◽  
Yogesh S. Sanghvi ◽  
P. Dan Cook
Keyword(s):  
Thymidine Dimer

Cockayne Syndrome: A Cellular Sensitivity to Ultraviolet Light

PEDIATRICS ◽  
1977 ◽  
Vol 60 (2) ◽  
pp. 135-139
Author(s):  
R. D. Schmickel ◽  
E. H. Y. Chu ◽  
J. E. Trosko ◽  
C. C. Chang
Keyword(s):  
Ultraviolet Light ◽  
Uv Light ◽  
Cockayne Syndrome ◽  
Fibroblast Cultures ◽  
Cellular Sensitivity ◽  
X Irradiation ◽  
Increased Sensitivity ◽  
Cellular Dna ◽  
Thymidine Dimer ◽  
Enzymatic Defect

Two unrelated children, a boy 2½ years old and a girl 4 years old, were affected with the cachectic dwarfism of Cockayne syndrome. Fibroblast cultures derived from these patients exhibited increased sensitivity to ultraviolet (UV) light, but not to x-irradiation, as measured by colony-forming ability. In both Cockayne fibroblast cultures, the rate of removal of thymidine dimer from the irradiated cellular DNA was normal. This demonstration of a cellular defect in Cockayne cells suggests that there may be an enzymatic defect in the repair of UV light-induced damage.

ChemInform Abstract: Synthesis of Thymidine Dimer Derivatives Containing an Amide Linkage and their Incorporation into Oligodeoxyribonucleotides.

ChemInform ◽  
2010 ◽  
Vol 25 (16) ◽  
pp. no-no
Author(s):  
J. LEBRETON ◽  
A. DE MESMAEKER ◽  
A. WALDNER ◽  
V. FRITSCH ◽  
R. M. WOLF ◽  
...  
Keyword(s):  
Amide Linkage ◽  
Thymidine Dimer

Synthesis of Thymidine Dimer Containing Novel (N-Acetyl)imino Linkage

2001 ◽  
Vol 48 (5) ◽  
pp. 949-952 ◽  
Author(s):  
Te-Fang Yang ◽  
Fang-Chi Chien ◽  
Fen-Yu Chung
Keyword(s):  
Thymidine Dimer

Inhibition of poly(ADP-ribose)polymerase binding to DNA by thymidine dimer

FEBS Letters ◽  
1999 ◽  
Vol 449 (1) ◽  
pp. 33-35
Author(s):  
Wan Seok Yang ◽  
Jin Woo Kim ◽  
Joon-Hwa Lee ◽  
Byong-Seok Choi ◽  
Cheol O. Joe
Keyword(s):  
Polymerase Binding ◽  
Thymidine Dimer
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