Immune mechanisms in acquired demyelinating neuropathies: lessons from animal models

2002 ◽  
Vol 12 (4) ◽  
pp. 405-414 ◽  
Author(s):  
Mathias Mäurer ◽  
Klaus V. Toyka ◽  
Ralf Gold
Keyword(s):  
Animal Models ◽  
Immune Mechanisms ◽  
Demyelinating Neuropathies ◽  
Acquired Demyelinating Neuropathies

scholarly journals Sphingomyelin as a myelin biomarker in CSF of acquired demyelinating neuropathies

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Giovanna Capodivento ◽  
Davide Visigalli ◽  
Martina Garnero ◽  
Roberto Fancellu ◽  
Michela Demetra Ferrara ◽  
...  
Keyword(s):  
Demyelinating Neuropathies ◽  
Acquired Demyelinating Neuropathies

51-year old man with tingling, burning and progressive limb weakness

2018 ◽  
Vol 18 (5) ◽  
pp. 382-388 ◽  
Author(s):  
Anu Gupta ◽  
Pappula Santhosh Kumar ◽  
Vinod Puri ◽  
Ravindra Kumar Saran ◽  
Poonam Narang ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Axonal Degeneration ◽  
Correct Diagnosis ◽  
Common Reason ◽  
Demyelinating Neuropathy ◽  
Limb Weakness ◽  
Immune Mediated ◽  
Demyelinating Neuropathies ◽  
Acquired Demyelinating Neuropathies

Peripheral neuropathy is a common reason for referral to neurology. Chronic acquired demyelinating neuropathies are an important and varied group with overlapping presentations, and may have an immune-mediated cause. Their correct diagnosis is important as they respond to different treatments; timely intervention can prevent irreversible axonal degeneration. We present a case that highlights the approach to an adult presenting with a chronic demyelinating neuropathy.

Polyneuropathy

2011 ◽  
Author(s):  
Michael Donaghy
Keyword(s):  
Conduction Block ◽  
Distal Limb ◽  
Nerve Roots ◽  
Demyelinating Neuropathies ◽  
Temperature Sensations ◽  
Acquired Demyelinating Neuropathies ◽  
Cardinal Sign ◽  
Distal Limb Muscle ◽  
Tendon Reflexes ◽  
Nerve Root Involvement

Typically polyneuropathy will cause the combination of distal limb muscle weakness, loss of tendon reflexes, and reduced distal limb sensation. There is variable involvement of the autonomic innervation, damage to which causes a dry, vasodilated foot or hand. Loss of tendon reflexes is a cardinal sign of polyneuropathy, often restricted to the ankle jerks in axonal degeneration, but involving more proximal reflexes in acquired demyelinating neuropathies which may involve more proximal segments or the nerve roots. Clinical features suggestive of demyelinating or conduction block polyneuropathy include: a relative lack of muscle wasting in relation to the degree of weakness because no denervation has occurred; weakness of proximal muscles as well as distal, because of nerve root involvement; and disproportionate loss of joint position and vibration sensations compared to relative preservation of pain and temperature sensations which are carried by unmyelinated fibres.

Immune mechanisms of stress susceptibility and resilience: Lessons from animal models

2019 ◽  
Vol 54 ◽  
pp. 100771 ◽  
Author(s):  
Mariya Tsyglakova ◽  
Dylan McDaniel ◽  
Georgia E. Hodes
Keyword(s):  
Animal Models ◽  
Immune Mechanisms ◽  
Stress Susceptibility
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