Age-related and mutation-independent proteomic changes in dystrophic mouse muscle

2017 ◽  
Vol 27 ◽  
pp. S5-S6
Author(s):  
T.L.E. van Westering ◽  
H.J. Johansson ◽  
A.M.L. Coenen-Stass ◽  
J. Tanihata ◽  
S. Takeda ◽  
...  
Keyword(s):  
Mouse Muscle ◽  
Dystrophic Mouse ◽  
Age Related

Enzyme studies of skeletal muscle in mice with hereditary muscular dystrophy

1963 ◽  
Vol 205 (5) ◽  
pp. 897-901 ◽  
Author(s):  
Marilyn W. McCaman
Keyword(s):  
Skeletal Muscle ◽  
Muscular Dystrophy ◽  
Glutathione Reductase ◽  
Enzyme Activities ◽  
Lactic Dehydrogenase ◽  
Normal Muscle ◽  
Dystrophic Muscle ◽  
Nerve Section ◽  
Mouse Muscle ◽  
Dystrophic Mouse

The activities of 20 enzymes in normal, heterozygous, and dystrophic mouse muscle were studied by means of quantitative microchemical methods. Enzyme activities in normal and heterozygous muscle were essentially the same. In dystrophic muscle glucose-6-P dehydrogenase, 6-P-gluconic dehydrogenase, glutathione reductase, peptidase, ß-glucuronidase, and glucokinase activities were significantly higher than in normal muscle, while α-glycero-P dehydrogenase and lactic dehydrogenase activities were significantly lower. The pattern of enzyme activities found in normal gastrocnemius denervated by nerve section was strikingly similar to that in dystrophic muscle.

Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle

Nature ◽  
1977 ◽  
Vol 270 (5639) ◽  
pp. 725-727 ◽  
Author(s):  
DAVID YAFFE ◽  
ORA SAXEL
Keyword(s):  
Myogenic Cells ◽  
Mouse Muscle ◽  
Dystrophic Mouse

BIOCHEMICAL STUDIES IN DYSTROPHIC MOUSE MUSCLE

1979 ◽  
Vol 317 (1 Muscular Dyst) ◽  
pp. 187-205 ◽  
Author(s):  
K. P. Strickland ◽  
A. J. Hudson ◽  
J. H. Thakar
Keyword(s):  
Mouse Muscle ◽  
Dystrophic Mouse ◽  
Biochemical Studies

ALDOLASE ACTIVITY IN NORMAL AND DYSTROPHIC MOUSE MUSCLE

1964 ◽  
Vol 42 (9) ◽  
pp. 1301-1305 ◽  
Author(s):  
U. Srivastava ◽  
L. Berlinguet
Keyword(s):  
Nitrogen Content ◽  
Total Nitrogen ◽  
Total Nitrogen Content ◽  
Dystrophic Muscle ◽  
Mouse Muscle ◽  
Dystrophic Mouse ◽  
Aldolase Activity ◽  
Dystrophic Mice

Aldolase activity and nitrogen content of the muscle were determined in hereditary muscular dystrophic mice and their normal litter mates at various ages. Aldolase activity was found to decrease in dystrophic muscle when expressed per mg of wet tissue but showed an increase at later stages of the disease when expressed per mg of total nitrogen in muscle. Total nitrogen content of dystrophic muscle decreased considerably during the evolution of the disease. In normal mice, the muscle aldolase activity increases with age.

Control of abnormal guanine nucleotide concentrations in dystrophic mouse muscle

1981 ◽  
Vol 9 (1) ◽  
pp. 74-75
Author(s):  
RICHARD J. SHUTTLEWOOD ◽  
JOHN R. GRIFFITHS
Keyword(s):  
Guanine Nucleotide ◽  
Mouse Muscle ◽  
Dystrophic Mouse

PROTEOLYTIC ENZYMES IN NORMAL AND DYSTROPHIC MOUSE MUSCLE

1966 ◽  
Vol 44 (5) ◽  
pp. 613-623 ◽  
Author(s):  
L. Berlinguet ◽  
U. Srivastava
Keyword(s):  
Proteolytic Enzymes ◽  
Chemical Change ◽  
Optimum Conditions ◽  
Normal Muscle ◽  
Dystrophic Muscle ◽  
Muscle Enzymes ◽  
Mouse Muscle ◽  
Ph Values ◽  
Dystrophic Mouse ◽  
Dystrophic Mice

Proteolytic enzymes extracted from normal and dystrophic mouse muscle were studied, and optimum conditions for their activities were established. It was found that these enzymes were active at two pH values, 7.5 and 9. In normal and dystrophic mice, the enzymatic activity increased with age. When the activities of dystrophic muscle enzymes were compared with those of normal muscle enzymes, the increase was most significant in animals 60–90 days of age. The results obtained when the enzymes extracted from normal or dystrophic muscle were incubated with substrates from normal or dystrophic muscle indicate that the defect in the muscle is due to an increase in the activities of the proteolytic enzymes rather than to a chemical change in the muscle proteins.

scholarly journals In vivo gene editing in dystrophic mouse muscle and muscle stem cells

Science ◽  
2015 ◽  
Vol 351 (6271) ◽  
pp. 407-411 ◽  
Author(s):  
M. Tabebordbar ◽  
K. Zhu ◽  
J. K. W. Cheng ◽  
W. L. Chew ◽  
J. J. Widrick ◽  
...  
Keyword(s):  
Stem Cells ◽  
Gene Editing ◽  
Mouse Muscle ◽  
Muscle Stem Cells ◽  
Dystrophic Mouse

Increased binding of α-bungarotoxin in dystrophic mouse muscle

1976 ◽  
Vol 51 (1) ◽  
pp. 132-140 ◽  
Author(s):  
P.R.C. Howe ◽  
B.G. Livett ◽  
L. Austin
Keyword(s):  
Mouse Muscle ◽  
Dystrophic Mouse
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