Rational design, synthesis and biological evaluation of thiadiazinoacridines: A new class of antitumor agents

A new class of C(6)-indole substituted celastrol derivatives were designed and synthesized. Among all these synthesized molecules, compound 4f and 4h displayed excellent in vitro antiproliferative activities against Bel7402 cancer cells.

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Toward a treatment of diabesity: Rational design, synthesis and biological evaluation of benzene-sulfonamide derivatives as a new class of PTP-1B inhibitors

Bioorganic Chemistry ◽

10.1016/j.bioorg.2019.01.052 ◽

2019 ◽

Vol 86 ◽

pp. 322-338 ◽

Cited By ~ 10

Author(s):

Nagat Ghareb ◽

Norhan M. El-Sayed ◽

Reda Abdelhameed ◽

Koji Yamada ◽

Mohamed Saleh Elgawish

Keyword(s):

Rational Design ◽

Biological Evaluation ◽

Design Synthesis ◽

New Class ◽

Ptp 1B ◽

Synthesis And Biological Evaluation

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Rational Design, Synthesis and Biological Evaluation of Novel Derivatives Based on in vivo Metabolism of Natural Product β-elemene

Letters in Drug Design & Discovery ◽

10.2174/1570180814666171108093021 ◽

2018 ◽

Vol 15 (8) ◽

pp. 905-912 ◽

Cited By ~ 1

Author(s):

Renren Bai ◽

Xiaokang Jie ◽

Eric Salgado ◽

Jian Sun ◽

Yao Zhu ◽

...

Keyword(s):

Natural Product ◽

Rational Design ◽

Biological Evaluation ◽

In Vivo Metabolism ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, synthesis, and biological evaluation of 3-(1-benzotriazole)-nor-β-lapachones as NQO1-directed antitumor agents

Bioorganic Chemistry ◽

10.1016/j.bioorg.2021.104995 ◽

2021 ◽

pp. 104995

Author(s):

Li-Qiang Wu ◽

Xin Ma ◽

Zhao-Peng Liu

Keyword(s):

Antitumor Agents ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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ChemInform Abstract: Antitumor Agents. Part 202. Novel 2′-Amino Chalcones: Design, Synthesis, and Biological Evaluation.

ChemInform ◽

10.1002/chin.200029085 ◽

2010 ◽

Vol 31 (29) ◽

pp. no-no

Author(s):

Yi Xia ◽

Zheng-Yu Yang ◽

Peng Xia ◽

Kenneth F. Bastow ◽

Yuka Nakanishi ◽

...

Keyword(s):

Antitumor Agents ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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3,5-Diaryl-1H-pyrazolo[3,4-b]pyridines as potent tubulin polymerization inhibitors: Rational design, synthesis and biological evaluation

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2018.12.053 ◽

2019 ◽

Vol 168 ◽

pp. 426-435 ◽

Cited By ~ 14

Author(s):

Min'an Zhai ◽

Shiyuan Liu ◽

Meiqi Gao ◽

Long Wang ◽

Jun Sun ◽

...

Keyword(s):

Rational Design ◽

Biological Evaluation ◽

Tubulin Polymerization ◽

Design Synthesis ◽

Tubulin Polymerization Inhibitors ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of novel 7-amino-[1,2,4]triazolo[4,3-f]pteridinone, and 7-aminotetrazolo[1,5-f]pteridinone derivative as potent antitumor agents

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2018.12.009 ◽

2019 ◽

Vol 163 ◽

pp. 690-709 ◽

Cited By ~ 19

Author(s):

Yunlei Hou ◽

Liangyu Zhu ◽

Zhiwei Li ◽

Qi Shen ◽

Qiaoling Xu ◽

...

Keyword(s):

Antitumor Agents ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of thiourea and nicotinamide-containing sorafenib analogs as antitumor agents

MedChemComm ◽

10.1039/c4md00536h ◽

2015 ◽

Vol 6 (5) ◽

pp. 867-870 ◽

Cited By ~ 12

Author(s):

Xiangkai Kong ◽

Zeyu Yao ◽

Zuopeng He ◽

Wenfang Xu ◽

Jianwen Yao

Keyword(s):

Antitumor Agents ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

Thiourea and nicotinamide-containing sorafenib analogs with better antiproliferative and anti-angiogenic activities than sorafenib were well designed and synthesized.

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