Evaluation of particle size distribution of albuterol sulfate hydrofluoroalkane administered via metered-dose inhaler with and without valved holding chambers

2005 ◽  
Vol 94 (1) ◽  
pp. 80-85 ◽  
Author(s):  
Courtney Crim ◽  
Mark Holmes ◽  
Benjamin Lee ◽  
Robb Cavanaugh ◽  
William Lincourt
Keyword(s):  
Particle Size ◽  
Particle Size Distribution ◽  
Size Distribution ◽  
Dose Inhaler ◽  
Metered Dose Inhaler ◽  
Metered Dose ◽  
Albuterol Sulfate

scholarly journals Foster®: A High-Efficiency Combination Metered Dose Inhaler with Consistent Particle Size Distribution at Alternative Flow Rates

2014 ◽  
Vol 4 (1-2) ◽  
pp. 1-5 ◽  
Author(s):  
Roberta De Maria ◽  
Ingrid Zagnoni ◽  
Alessandro Bodria ◽  
Sauro Bonelli ◽  
Massimiliano Dagli Alberi ◽  
...  
Keyword(s):  
Particle Size ◽  
Particle Size Distribution ◽  
Size Distribution ◽  
High Efficiency ◽  
Dose Inhaler ◽  
Metered Dose Inhaler ◽  
Flow Rates ◽  
Metered Dose

Evaluation of particle size distribution of salmeterol administered via metered-dose inhaler with and without valved holding chambers

2001 ◽  
Vol 87 (6) ◽  
pp. 482-487 ◽  
Author(s):  
H. William Kelly ◽  
Richard C. Ahrens ◽  
Mark Holmes ◽  
Anne L. Stevens ◽  
Anna K. Vandermeer ◽  
...  
Keyword(s):  
Particle Size ◽  
Particle Size Distribution ◽  
Size Distribution ◽  
Dose Inhaler ◽  
Metered Dose Inhaler ◽  
Metered Dose

EVALUATION OF AERODYNAMIC PARTICLE SIZE DISTRIBUTION OF DRUGS USED IN INHALATION THERAPY: A CONCISE REVIEW

2020 ◽  
Vol 8 (7) ◽  
pp. 264-271
Author(s):  
Smita Nayak ◽  
Priyanka Ghugare ◽  
Bhaskar Vaidhun
Keyword(s):  
Particle Size ◽  
Particle Size Distribution ◽  
Size Distribution ◽  
Dry Powder Inhaler ◽  
Dose Inhaler ◽  
Metered Dose Inhaler ◽  
Aerodynamic Particle Size Distribution ◽  
Metered Dose ◽  
Aerodynamic Particle Size ◽  
Cascade Impactors

Most of the inhalation products in the market use metered dose inhaler (MDI) technology or dry powder inhaler (DPI) technology. MDIs use propellant to deliver desired dose of liquid formulation in aerosol form. DPI contains active in fine particulate form embedded onto an inert carrier. In both cases, amount of drug dispensed from the device reaching the lungs is dependent upon drug product characteristics as well as formulation-device relationship. Hence, in addition to particle size, aerodynamic distribution of the drug upon delivery by the device plays an important role in determining amount of drug reaching the lungs. Therefore particle size characterization is an important tool in determining the extent of drug delivery from the metered dose inhaler. Aerodynamic particle size distribution is frequently determined by use of cascade impactors and data so generated is accepted by regulatory agencies as a tool for predicting efficacy of MDIs and DPIs. This review discusses principle and working of cascade impactors. Additionally, the review also examines the role of laser diffraction technique in estimating size of dispersed particles.

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