P-211 T-wave morphology analysis in healthy subjects and in patients with cardiac disorders

<span>The accuracy of electrocardiogram (ECG) delineation can affect the precise diagnose for cardiac disorders interpretation. Some nonideal ECG presentation can make a false decision in precision medicine. Besides, the physiological variation of heart rate and different characteristics of the different ECG waves in terms of shape, frequency, amplitude, and duration is also affected. <span>This paper proposes a discrete wavelet transform (DWT), non-stationary signal analysis for noise removal, and onset-offset of PQRST feature extraction. A well-known database from Physionet: QT database (QTDB) is used to validate the DWT function for detecting the onset and offset of P-wave, QRS-complex, and T-wave localization. From the results, P-peak detection gets the highest result that achieves 2.19 and 13.62 milliseconds of mean error and standard deviation, respectively. In contrast, Toff has obtained the highest error value due to differences in the T-wave morphology. It can be affected by inverted o</span>r biphasic T-waves and others.</span>

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P-071 Evaluation of the risk of ventricular tachyarrhythmia recurrence in patients with ischaemic heart disease by T-wave morphology analysis

EP Europace ◽

10.1016/s1099-5129(03)91823-x ◽

2003 ◽

Vol 4 ◽

pp. B83

Author(s):

Y GANG

Keyword(s):

Heart Disease ◽

Ischaemic Heart Disease ◽

Ventricular Tachyarrhythmia ◽

T Wave ◽

Morphology Analysis ◽

Wave Morphology

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Abstract 17250: Quantitative T Wave Morphology Analysis in Rett Syndrome Patients

Circulation ◽

10.1161/circ.142.suppl_3.17250 ◽

2020 ◽

Vol 142 (Suppl_3) ◽

Author(s):

Michael Collins ◽

Hoang Nguyen ◽

Mark Johnson ◽

Robin Ryther ◽

Judith Weisenberg

Keyword(s):

Sudden Death ◽

Rett Syndrome ◽

Principal Component ◽

Cardiac Repolarization ◽

T Wave ◽

Morphology Analysis ◽

Abnormal Morphology ◽

Torsades Des Pointes ◽

Wave Morphology ◽

Electrocardiogram Ecg

Introduction: Rett syndrome (RTT) is a genetic neurologic disorder associated with a high incidence of sudden death. Abnormal cardiac repolarization is a potential risk factor for sudden death in this population. RTT patients may have prolonged corrected QT (QTc) on electrocardiogram (ECG) that is a sensitive marker of torsades des pointes. However, other repolarization markers such as T wave morphology, the time it takes the T wave to return to baseline from peak amplitude (Tpeak - Tend), and heart rate corrected JTpeak have not been studied. Hypothesis: Rett syndrome patients have abnormal cardiac repolarization. Methods: Retrospective T wave analysis was performed using QT Guard software. T wave morphology and heterogeneity parameters of RTT patients were compared to ECGs of age and sex matched healthy controls. A composite T wave morphology score was calculated from individual feature of flatness, notching, and asymmetry; a higher score means more abnormal morphology. Heterogeneity of repolarization was represented by the principal component analysis ratio 2 (PCA-2). Results: 57 Rett patients (260 ECG) and 121 controls (134 ECG) were studied. The RTT group had longer QTc (p = 0.001) along with more abnormal T-wave morphology scores and heterogeneity parameters when compared to controls (Tables 1, 2). RTT patients without long QTc also had more abnormal morphology scores than controls (p = 0.001). Conclusion: Cardiac repolarization is diffusely abnormal in RTT even in the absence of long QTc. T wave morphology analysis may be used to detect and monitor abnormal cardiac repolarization in RTT in clinical practice.

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