Pallidal deep brain stimulation in patients with primary generalised or segmental dystonia: 5-year follow-up of a randomised trial

2012 ◽  
Vol 11 (12) ◽  
pp. 1029-1038 ◽  
Author(s):  
Jens Volkmann ◽  
Alexander Wolters ◽  
Andreas Kupsch ◽  
Jörg Müller ◽  
Andrea A Kühn ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Randomised Trial ◽  
Segmental Dystonia ◽  
Pallidal Deep Brain Stimulation ◽  
Deep Brain

scholarly journals Unilateral thalamic and pallidal deep brain stimulation for idiopathic hemidystonia: results of individual and combined stimulations. Case report

2017 ◽  
Vol 43 (1) ◽  
pp. E2 ◽  
Author(s):  
Victor Goulenko ◽  
Paulo Luiz da Costa Cruz ◽  
Paulo Niemeyer Filho
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Rating Scale ◽  
Multiple Target ◽  
Motor Pathways ◽  
Severity Rating ◽  
Pallidal Stimulation ◽  
Pallidal Deep Brain Stimulation ◽  
Deep Brain

Pallidal stimulation has been the usual surgical treatment for dystonia in the last decades. The continuous investigation of the physiopathology and the motor pathways involved leads to the search for complementary targets to improve results. The authors present the case of a 37-year-old woman who had suffered from idiopathic hemidystonia with hyperkinetic and hypokinetic movements for 11 years, and who was treated with deep brain stimulation. A brief literature review is also provided. The globus pallidus internus and the ventral intermediate/ventral oral posterior complex of the thalamus were stimulated separately and simultaneously for 3 months and compared using the Burke-Fahn-Marsden Dystonia Rating Scale and the Global Dystonia Severity Rating Scale, with a 3.5-year follow-up. The synergism of multiple-target stimulation resulted in a complete improvement of the mixed dystonic symptoms.

Successful pallidal deep brain stimulation in 15-year-old with Tourette syndrome: 2-year follow-up

2013 ◽  
Vol 260 (9) ◽  
pp. 2417-2419 ◽  
Author(s):  
João Massano ◽  
Cláudia Sousa ◽  
Tom Foltynie ◽  
Ludvic Zrinzo ◽  
Marwan Hariz ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Tourette Syndrome ◽  
Brain Stimulation ◽  
Pallidal Deep Brain Stimulation ◽  
Deep Brain

Risperidone-responsive segmental dystonia and pallidal deep brain stimulation

Neurology ◽  
2003 ◽  
Vol 61 (4) ◽  
pp. 546-548 ◽  
Author(s):  
J. C. Wohrle ◽  
R. Weigel ◽  
E. Grips ◽  
C. Blahak ◽  
H. H. Capelle ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Segmental Dystonia ◽  
Pallidal Deep Brain Stimulation ◽  
Deep Brain

Deep Brain Stimulation for Dystonia

2020 ◽  
pp. 185-194
Author(s):  
Mitesh Lotia
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Short Term ◽  
Gradual Onset ◽  
Primary Dystonia ◽  
Relative Scarcity ◽  
Pallidal Deep Brain Stimulation ◽  
Deep Brain

The past two decades have revealed substantial benefits of bilateral pallidal deep brain stimulation (DBS) in patients with medication-refractory primary dystonia. There is a growing body of evidence now describing not only short-term but also long-term benefits up to 10 years following DBS. These benefits are often sustained, requiring minimal long-term modification. Pallidal programming for dystonia may be complex owing to the gradual onset of benefits and often delayed development of side effects. There is a relative scarcity of evidence-based recommendations for standardized programming methods. This chapter reviews essential factors to consider for appropriate patient selection and discusses strategies for initial and follow-up programming. Finally, the chapter describes the potential short-term and long-term adverse effects, while considering various strategies to mitigate them.

scholarly journals Pallidal Deep Brain Stimulation Reduces Sensorimotor Cortex Activation in Focal/Segmental Dystonia

2020 ◽  
Vol 35 (4) ◽  
pp. 629-639 ◽  
Author(s):  
Andrea Greuel ◽  
K. Amande M. Pauls ◽  
Anne Koy ◽  
Martin Südmeyer ◽  
Alfons Schnitzler ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Sensorimotor Cortex ◽  
Segmental Dystonia ◽  
Pallidal Deep Brain Stimulation ◽  
Deep Brain

scholarly journals Successful Pallidal Deep Brain Stimulation Treatment in a Case of Generalized Dystonia due to a Novel ANO3 Mutation

2019 ◽  
Vol 2019 ◽  
pp. 1-2 ◽  
Author(s):  
Lizl Lasky ◽  
Lindsay Bliss ◽  
Christos Sidiropoulos
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Case Series ◽  
Long Term Outcomes ◽  
Pallidal Stimulation ◽  
Generalized Dystonia ◽  
Pallidal Deep Brain Stimulation ◽  
Deep Brain

Background. Dystonia is a ubiquitous syndrome, with a growing number of genes being continually identified. Mutations in the anoctamin-3 gene have been described to cause dystonia but the management and long-term outcomes are still largely unknown. Methods. We present here a long term, longitudinal follow up of a patient with generalized dystonia, who was treated with bilateral pallidal deep brain stimulation and was found to harbor a mutation in the anoctamin-3 gene. Results. Ongoing adjustment of stimulation settings and medications led to good and sustained dystonia control; however the patient did suffer short term relapses, manifested as dystonic crisis, which necessitated inpatient admission. Conclusion. This only the second patient to be reported with pallidal stimulation and an anoctamin-3 gene mutation. Long term outcomes seem to be favorable but larger case series are needed to confirm our findings.

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