577 THE EFFECT OF ORAL TOLTERODINE SLOW RELEASE ON BLADDER ELECTRICAL PERCEPTION THRESHOLD (EPT) - A PLACEBO CONTROLLED DOUBLE BLIND STUDY WITH 4 AND 8MG IN HEALTHY VOLUNTEERS

In a double-blind study performed in 81 healthy volunteers, 10 mg cetirizine and 60 mg terfenadine given orally in a single administration significantly inhibited skin reactivity to histamine. Astemizole (10 mg) was completely ineffective. The inhibitory effect of cetirizine was potent and regular whereas 6/28 (21%) volunteers did not respond to terfenadine. The difference observed beween cetirizine and terfenadine might be due to differences in the metabolism of the two drugs after administration: terfenadine is rapidly and extensively metabolized whereas cetirizine is directly active without the need for biotransformation and, indeed is poorly metabolized.

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The pharmacokinetic and pharmacodynamic relationship between apraglutide and citrulline: a randomized, placebo-controlled, double-blind study in healthy volunteers

Clinical Nutrition ESPEN ◽

10.1016/j.clnesp.2020.09.035 ◽

2020 ◽

Vol 40 ◽

pp. 413-414

Author(s):

F. Bolognani ◽

P. Gal ◽

M. Moerland ◽

A. Kruithof ◽

M. van Gent ◽

...

Keyword(s):

Healthy Volunteers ◽

Blind Study ◽

Double Blind Study ◽

Double Blind

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Double blind study of the influence of co-dergocrine on platelet parameters in healthy volunteers

European Journal of Clinical Pharmacology ◽

10.1007/bf00607922 ◽

1985 ◽

Vol 28 (6) ◽

pp. 713-716 ◽

Cited By ~ 2

Author(s):

H. Sinzinger

Keyword(s):

Healthy Volunteers ◽

Blind Study ◽

Double Blind Study ◽

Double Blind

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No Effect Of Persantin On Platelet Aggregation And Plasma βTg Levels In Healthy Volunteers

10.1055/s-0038-1653236 ◽

1981 ◽

Author(s):

A W A Lensing ◽

A Sturk ◽

J W ten Cate

Keyword(s):

Side Effects ◽

Healthy Volunteers ◽

Cerebrovascular Accident ◽

Slow Release ◽

Double Blind Study ◽

Prolonged Administration ◽

Double Blind ◽

Normal Limits ◽

Induced Aggregation ◽

Release Form

Previous studies from our laboratory revealed no effect of aspirin on plasma βTG levels in healthy volunteers as well as in patients with cerebrovascular accident. This double blind study was undertaken to investigate the effect of prolonged administration of Persantin. Two groups of 10 volunteers each received 4×100 mg Persantin or 2×200 mg daily in slow release form for 21 days. Platelet studies were performed prior to- and once every week during the trial. The volunteers refrained from smoking and were not on oral contraceptives or other drugs. No effect was observed on ADP (1 μ M f.c.) or collagen induced aggregation. All βTG plasma levels were within normal limits i.e. below 60/ml of plasma. No tendency of decreasing levels was observed. Side effects were significantly more observed in the volunteers on slow release Persantin (Mean Whitney Test α < 0.025). Side effects included sensations of a dry mouth and thirst, headache and di2Lzyness.

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