Sample Size Choice for Microarray Experiments

2009 ◽  
pp. 425-437
Author(s):  
Peter Müller ◽  
Christian Robert ◽  
Judith Rousseau ◽  
Marina Vannucci
Keyword(s):  
Sample Size ◽  
Microarray Experiments

Sample size calculation for a regularized -statistic in microarray experiments

2011 ◽  
Vol 81 (7) ◽  
pp. 870-875 ◽  
Author(s):  
Akihiro Hirakawa ◽  
Chikuma Hamada ◽  
Isao Yoshimura
Keyword(s):  
Sample Size ◽  
Sample Size Calculation ◽  
Microarray Experiments

Microarray experimental design: power and sample size considerations

2003 ◽  
Vol 16 (1) ◽  
pp. 24-28 ◽  
Author(s):  
M. C. K. Yang ◽  
J. J. Yang ◽  
R. A. McIndoe ◽  
J. X. She
Keyword(s):  
Sample Size ◽  
Gene Expression Analysis ◽  
Microarray Technology ◽  
Microarray Experiments ◽  
False Discovery ◽  
Powerful Approach ◽  
Design Power ◽  
Single Time Point ◽  
Time Point

Gene expression analysis using high-throughput microarray technology has become a powerful approach to study systems biology. The exponential growth in microarray experiments has spawned a number of investigations into the reliability and reproducibility of this type of data. However, the sample size requirements necessary to obtain statistically significant results has not had as much attention. We report here statistical methods for the determination of the sufficient number of subjects necessary to minimize the false discovery rate while maintaining high power to detect differentially expressed genes. Two experimental designs were considered: 1) a comparison between two groups at a single time point, and 2) a comparison of two experimental groups with sequential time points. Computer programs are available for the methods discussed in this paper and are adaptable to more complicated situations.

scholarly journals Sample size calculation for microarray experiments with blocked one-way design

2009 ◽  
Vol 10 (1) ◽  
Author(s):  
Sin-Ho Jung ◽  
Insuk Sohn ◽  
Stephen L George ◽  
Liping Feng ◽  
Phyllis C Leppert
Keyword(s):  
Sample Size ◽  
Sample Size Calculation ◽  
Microarray Experiments

scholarly journals Practical FDR-based sample size calculations in microarray experiments

2005 ◽  
Vol 21 (15) ◽  
pp. 3264-3272 ◽  
Author(s):  
J. Hu ◽  
F. Zou ◽  
F. A. Wright
Keyword(s):  
Sample Size ◽  
Microarray Experiments ◽  
Sample Size Calculations
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