Cerebral vasoreactivity

2001 ◽  
pp. 324-334 ◽  
Author(s):  
Bernhard Widder
Keyword(s):  
Cerebral Vasoreactivity

Evaluation of Cerebral Vasoreactivity by SPECT and Transcranial Doppler Sonography using the Acetazolamide Test

1994 ◽  
Vol 33 (06) ◽  
pp. 239-243 ◽  
Author(s):  
F. Grünwald ◽  
P. Barzó ◽  
E. Ambrus ◽  
C. Menzel ◽  
A. Schomburg ◽  
...  
Keyword(s):  
Transcranial Doppler ◽  
Doppler Sonography ◽  
Transcranial Doppler Sonography ◽  
Transkranielle Dopplersonographie ◽  
99Mtc Hmpao ◽  
Cerebral Vasoreactivity

ZusammenfassungBei 29 Patienten (3 Kontrollpersonen, 26 Patienten mit zerebrovaskulärer Erkrankung) wurde prospektiv die Hirn-SPECT mit 99mTC-HMPAO und bei 20 Patienten (3 Kontrollpersonen, 17 Patienten mit ZVK) die transkranielle Dopplersonographie (TCD) vor und nach i. v. Gabe von Azetazolamid durchgeführt. Die Sensitivität der Hirn-SPECT erhöhte sich mit Azetazolamid von 62% auf 77%. Bei Patienten mit reversiblem neurologischem Defizit wurde eine Verbesserung von 50% auf 71 %, bei Patienten mit persistierendem Defizit von 75% auf 83% beobachtet. Die Ergebnisse der Hirn-SPECT und der TCD stimmten in der Beurteilung der zerebro-vaskulären Reservekapazität in 91% der Hemisphären überein. Die Korrelation zwischen den beiden Methoden war statistisch signifikant.

scholarly journals Ubiquinol Supplementation Improves Gender-Dependent Cerebral Vasoreactivity and Ameliorates Chronic Inflammation and Endothelial Dysfunction in Patients with Mild Cognitive Impairment

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 143
Author(s):  
Sonia García-Carpintero ◽  
Javier Domínguez-Bértalo ◽  
Cristina Pedrero-Prieto ◽  
Javier Frontiñán-Rubio ◽  
Mariano Amo-Salas ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Vascular Dysfunction ◽  
Transcranial Doppler Sonography ◽  
Endothelial Damage ◽  
Microvascular Endothelial Cell ◽  
Neurological Improvement ◽  
Male Patients ◽  
Cerebral Vasoreactivity

Ubiquinol can protect endothelial cells from multiple mechanisms that cause endothelial damage and vascular dysfunction, thus contributing to dementia. A total of 69 participants diagnosed with mild cognitive impairment (MCI) received either 200 mg/day ubiquinol (Ub) or placebo for 1 year. Cognitive assessment of patients was performed at baseline and after 1 year of follow-up. Patients’ cerebral vasoreactivity was examined using transcranial Doppler sonography, and levels of Ub and lipopolysaccharide (LPS) in plasma samples were quantified. Cell viability and necrotic cell death were determined using the microvascular endothelial cell line bEnd3. Coenzyme Q10 (CoQ) levels increased in patients supplemented for 1 year with ubiquinol versus baseline and the placebo group, although higher levels were observed in male patients. The higher cCoQ concentration in male patients improved cerebral vasoreactivity CRV and reduced inflammation, although the effect of Ub supplementation on neurological improvement was negligible in this study. Furthermore, plasma from Ub-supplemented patients improved the viability of endothelial cells, although only in T2DM and hypertensive patients. This suggests that ubiquinol supplementation could be recommended to reach a concentration of 5 μg/mL in plasma in MCI patients as a complement to conventional treatment.

scholarly journals Cerebral vasoreactivity is not impaired in patients with severe sepsis

Critical Care ◽  
2011 ◽  
Vol 15 (S1) ◽  
Author(s):  
S Szatmári ◽  
Z Fülep ◽  
P Sárkány ◽  
C Antek ◽  
P Siró ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
Cerebral Vasoreactivity

Cerebral Vasoreactivity Assessed With Transcranial Doppler and Regional Cerebral Blood Flow Measurements

Stroke ◽  
1995 ◽  
Vol 26 (12) ◽  
pp. 2302-2306 ◽  
Author(s):  
Arve Dahl ◽  
David Russell ◽  
Kjell Rootwelt ◽  
Rolf Nyberg-Hansen ◽  
Emilia Kerty
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Transcranial Doppler ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Flow Measurements ◽  
Blood Flow Measurements ◽  
Cerebral Vasoreactivity

P1-266: LONG-TERM BLOOD PRESSURE EXPOSURE AND CEREBRAL VASOREACTIVITY: DOES RACE MATTER?

2006 ◽  
Vol 14 (7S_Part_7) ◽  
pp. P383-P383
Author(s):  
Cristina Duque ◽  
Behnam Sabayan ◽  
Chaney R. Garner ◽  
Shawn Kurian ◽  
Isabelle Van der Velpen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cerebral Vasoreactivity

scholarly journals Cerebral vasoreactivity during hypercapnia is reset by augmented sympathetic influence

2011 ◽  
Vol 110 (2) ◽  
pp. 352-358 ◽  
Author(s):  
Peizhen Zhang ◽  
Guoyuan Huang ◽  
Xiangrong Shi
Keyword(s):  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Near Infrared ◽  
Lower Body Negative Pressure ◽  
Transcranial Doppler Sonography ◽  
Nerve Activity ◽  
Hemodynamic Responses ◽  
Cerebral Hemodynamic ◽  
End Tidal ◽  
Cerebral Vasoreactivity

Sympathetic nerve activity influences cerebral blood flow, but it is unknown whether augmented sympathetic nerve activity resets cerebral vasoreactivity to hypercapnia. This study tested the hypothesis that cerebral vasodilation during hypercapnia is restrained by lower-body negative pressure (LBNP)-stimulated sympathoexcitation. Cerebral hemodynamic responses were assessed in nine healthy volunteers [age 25 yr (SD 3)] during rebreathing-induced increases in partial pressure of end-tidal CO2 (PetCO2) at rest and during LBNP. Cerebral hemodynamic responses were determined by changes in flow velocity of middle cerebral artery (MCAV) using transcranial Doppler sonography and in regional cerebral tissue oxygenation (ScO2) using near-infrared spectroscopy. PetCO2 values during rebreathing were similarly increased from 41.9 to 56.5 mmHg at rest and from 40.7 to 56.0 mmHg during LBNP of −15 Torr. However, the rates of increases in MCAV and in ScO2 per unit increase in PetCO2 (i.e., the slopes of MCAV/PetCO2 and ScO2/PetCO2) were significantly ( P ≤0.05) decreased from 2.62 ± 0.16 cm·s−1·mmHg−1 and 0.89 ± 0.10%/mmHg at rest to 1.68 ± 0.18 cm·s−1·mmHg−1 and 0.63 ± 0.07%/mmHg during LBNP. In conclusion, the sensitivity of cerebral vasoreactivity to hypercapnia, in terms of the rate of increases in MCAV and in ScO2, is diminished by LBNP-stimulated sympathoexcitation.

Sign in / Sign up

Export Citation Format

Share Document