Cognitive correlates of visual and minor hallucinations in Parkinson’s disease

AbstractParkinson’s disease (PD) is primarily a motor disorder that involves the gradual loss of motor function. Symptoms are observed initially in the extremities, such as hands and arms, while advanced stages of the disease can effect blinking, swallowing, speaking, and breathing. PD is a neurodegenerative disease, with dopaminergic neuronal loss occurring in the substantia nigra pars compacta, thus disrupting basal ganglia functions. This leads to downstream effects on other neurotransmitter systems such as glutamate, γ-aminobutyric acid, and serotonin. To date, one of the main treatments for PD is levodopa. While it is generally very effective, prolonged treatments lead to levodopa-induced dyskinesia (LID). LID encompasses a family of symptoms ranging from uncontrolled repetitive movements to sustained muscle contractions. In many cases, the symptoms of LID can cause more grief than PD itself. The purpose of this review is to discuss the possible clinical features, cognitive correlates, neural substrates, as well as potential psychopharmacological and surgical (including nondopaminergic and deep brain stimulation) treatments of LID.

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Identifying axial and cognitive correlates in patients with Parkinson’s disease motor subtype using the instrumented Timed Up and Go

Experimental Brain Research ◽

10.1007/s00221-013-3778-8 ◽

2013 ◽

Vol 232 (2) ◽

pp. 713-721 ◽

Cited By ~ 32

Author(s):

Talia Herman ◽

Aner Weiss ◽

Marina Brozgol ◽

Nir Giladi ◽

Jeffrey M. Hausdorff

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Timed Up And Go ◽

Cognitive Correlates

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A Comparison of Functional Abilities in Individuals with Mild Cognitive Impairment and Parkinson’s Disease with Mild Cognitive Impairment Using Multiple Assessment Methods

Journal of the International Neuropsychological Society ◽

10.1017/s1355617721001077 ◽

2021 ◽

pp. 1-12

Author(s):

Maureen Schmitter-Edgecombe ◽

Courtney McAlister ◽

David Greeley

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Direct Observation ◽

Functional Performance ◽

Assessment Methods ◽

Cognitive Correlates ◽

Motor Abilities ◽

Multiple Assessment

Abstract Objective: This study used multiple assessment methods to examine instrumental activities of daily living (IADLs) performance in individuals with Parkinson’s disease with mild cognitive impairment (PD-MCI) compared to individuals with mild cognitive impairment (MCI) and cognitively healthy older adults (HOA). Associations between functional performance and cognition were also examined. Methods: Eighteen individuals with PD-MCI, 48 individuals with MCI, and 66 HOAs were assessed with multiple IADL measures, including direct observation, a performance-based measure, and self- and informant-report questionnaires. Performance on the direct-observation measure was further characterized by coding for four error types: omissions, substitutions, and inefficient and irrelevant/off-task actions. Results: Both the PD-MCI and MCI groups performed more poorly on the overall score for all IADL measures relative to HOAs. Although the PD-MCI and MCI groups did not differ in overall performance, on the direct-observation measure, the PD-MCI group took longer and made more inefficient and irrelevant/off-task errors relative to the HOA and MCI groups, whereas the MCI group made more omission and substitution errors relative to HOAs. Further, the pattern of cognitive correlates that associated most strongly with the functional measures varied across groups and functional assessment methods. Conclusion: Compared to HOAs, PD-MCI and MCI groups demonstrated increased difficulties performing everyday activities, and cognitive and motor abilities differentially contributed to the everyday task difficulties of these two groups.

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HEDONIC TONE AND ITS MOOD AND COGNITIVE CORRELATES IN PARKINSON'S DISEASE

Depression and Anxiety ◽

10.1002/da.22036 ◽

2013 ◽

Vol 30 (1) ◽

pp. 85-91 ◽

Cited By ~ 7

Author(s):

Gianfranco Spalletta ◽

Sabrina Fagioli ◽

Giuseppe Meco ◽

Mariangela Pierantozzi ◽

Alessandro Stefani ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Hedonic Tone ◽

Cognitive Correlates

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Neural substrates and potential treatments for levodopa-induced dyskinesias in Parkinson’s disease

Identifying axial and cognitive correlates in patients with Parkinson’s disease motor subtype using the instrumented Timed Up and Go

A Comparison of Functional Abilities in Individuals with Mild Cognitive Impairment and Parkinson’s Disease with Mild Cognitive Impairment Using Multiple Assessment Methods

HEDONIC TONE AND ITS MOOD AND COGNITIVE CORRELATES IN PARKINSON'S DISEASE

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