HEDONIC TONE AND ITS MOOD AND COGNITIVE CORRELATES IN PARKINSON'S DISEASE

2013 ◽  
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Sabrina Fagioli ◽  
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Mariangela Pierantozzi ◽  
Alessandro Stefani ◽  
...  
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...  

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Doaa H. Hewedi

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Delia Lorenz ◽  
Jens Volkmann ◽  
...  

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Murat Emre ◽  
Sibel Tekin ◽  
Siri B. Haugen ◽  
Dag Aarsland

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...  

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Vol 20 (12) ◽  
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...  

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Vol 27 (7) ◽  
pp. 729-738 ◽  
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Abeer M. Eissa ◽  
Doaa H. Hewedi ◽  
Marjan Jahanshahi ◽  
Mohamed El-Gamal ◽  
...  

AbstractParkinson’s disease (PD) is primarily a motor disorder that involves the gradual loss of motor function. Symptoms are observed initially in the extremities, such as hands and arms, while advanced stages of the disease can effect blinking, swallowing, speaking, and breathing. PD is a neurodegenerative disease, with dopaminergic neuronal loss occurring in the substantia nigra pars compacta, thus disrupting basal ganglia functions. This leads to downstream effects on other neurotransmitter systems such as glutamate, γ-aminobutyric acid, and serotonin. To date, one of the main treatments for PD is levodopa. While it is generally very effective, prolonged treatments lead to levodopa-induced dyskinesia (LID). LID encompasses a family of symptoms ranging from uncontrolled repetitive movements to sustained muscle contractions. In many cases, the symptoms of LID can cause more grief than PD itself. The purpose of this review is to discuss the possible clinical features, cognitive correlates, neural substrates, as well as potential psychopharmacological and surgical (including nondopaminergic and deep brain stimulation) treatments of LID.


Author(s):  
Abhishek Lenka ◽  
Shantala Hegde ◽  
Shyam Sundar Arumugham ◽  
Puneet Singh ◽  
Ravi Yadav ◽  
...  

2013 ◽  
Vol 232 (2) ◽  
pp. 713-721 ◽  
Author(s):  
Talia Herman ◽  
Aner Weiss ◽  
Marina Brozgol ◽  
Nir Giladi ◽  
Jeffrey M. Hausdorff

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