Comparison of the live vaccine potential of different geographic isolates of Schistosoma mansoni

1987 ◽  
Vol 61 (3) ◽  
pp. 191-195 ◽  
Author(s):  
Q. D. Bickle ◽  
M. J. Doenhoff
Keyword(s):  
Schistosoma Mansoni ◽  
Live Vaccine ◽  
Significant Protection ◽  
Degree Of Protection ◽  
Geographic Origins ◽  
Vaccine Potential

ABSTRACTWe have investigated the capacity of irradiated larvae of each of six different isolates of Schistosoma mansoni to protect mice against challenge infections from the homologous or a different isolate. The isolates differed in respect of their geographic origins, and in the lengths of time they had been maintained in the laboratory. All isolates induced significant protection against unattenuated challenge infections, and neither the degree of geographic disimilarity between vaccinating and challenge parasites, nor the numbers of laboratory cycles, appeared to influence the degree of protection induced by irradiation-attenuated larvae.

Effect of Organic Corrosion Inhibitors on Corrosion Fatigue

CORROSION ◽  
1967 ◽  
Vol 23 (3) ◽  
pp. 65-71 ◽  
Author(s):  
PARVIZ MEHDIZADEH ◽  
R. L. McGLASSON ◽  
J. E. LANDERS
Keyword(s):  
Corrosion Fatigue ◽  
Diesel Fuel ◽  
Corrosion Inhibitors ◽  
Fatigue Cracks ◽  
Material Surface ◽  
Significant Protection ◽  
Inhibitor Concentration ◽  
Degree Of Protection ◽  
Organic Inhibitors ◽  
Organic Corrosion Inhibitors

Abstract The effect of organic inhibitors on corrosion fatigue performance of steel in a mixture of brine containing H2S-CO2 and diesel fuel is reported. The inhibitor concentration required to give significant protection to steel under corrosion fatigue conditions is much higher than that for corrosion control. This is due to the fact that corrosion fatigue cracks initiated at incompletely protected spots on the material surface influence fatigue failure regardless of the degree of protection achieved on neighboring areas. Effects of fatigue stress and concentration of corrosion inhibitors were investigated. Results were analyzed in terms of the proposed mechanism for corrosion inhibition in these environments.

Combination of the two schistosomal antigens Sm14 and Sm29 elicits significant protection against experimental Schistosoma mansoni infection

2014 ◽  
Vol 145 ◽  
pp. 51-60 ◽  
Author(s):  
Radwa E. Ewaisha ◽  
Mohammed Bahey-El-Din ◽  
Shereen F. Mossallam ◽  
Eglal I. Amer ◽  
Hamida M. Aboushleib ◽  
...  
Keyword(s):  
Schistosoma Mansoni ◽  
Significant Protection

Induction of protective immunity toBrugia pahangiin jirds by drug-abbreviated infection

1992 ◽  
Vol 66 (2) ◽  
pp. 147-154 ◽  
Author(s):  
Y. Horii ◽  
H. Nakanishi ◽  
A. Mori ◽  
M. Ueda ◽  
K. Kurokawa ◽  
...  
Keyword(s):  
Post Infection ◽  
Primary Infection ◽  
Protective Immunity ◽  
Challenge Infection ◽  
Significant Protection ◽  
Patent Period ◽  
Infection Period ◽  
Degree Of Protection ◽  
Infected Adult ◽  
Homologous Challenge

ABSTRACTProtective immunity of homologous challenge infection was examined in jirds after drug-abbreviated infection withBrugia pahangi. Mebendazole (MBZ) treatment at the early prepatent (5–7 weeks of post infection) or the late prepatent (7–9 weeks of post infection) period was highly effective in causing almost complete eradication of the primary infection. After challenge infection, the worm burden was significantly reduced 19% (31·1 in average) and 77% (9·5) to that of the controls (38·8 and 41·7), respectively. The magnitude of eosinophil response paralleled the degree of protection. No or only a few microfilariae were seen after challenge infection in jirds treated during the prepatent periods. They were also resistant to intravenous challenge with the microfilariae ofB. pahangi. MBZ treatment at the patent period was, on the contrary, incomplete against primarily infected adult worms, and was not able to induce either significant protection (30·1 vs 33·1 in control) or eosinophil response to the challenge infection.

scholarly journals Virulence Attenuation and Live Vaccine Potential of aroA, crp cdt cya, and Plasmid-Cured Mutants of Salmonella enterica Serovar Abortusovis in Mice and Sheep

2005 ◽  
Vol 73 (7) ◽  
pp. 4302-4308 ◽  
Author(s):  
Sergio Uzzau ◽  
Gavino Marogna ◽  
Guido Sisinnio Leori ◽  
Roy Curtiss ◽  
Giuseppe Schianchi ◽  
...  
Keyword(s):  
Salmonella Enterica ◽  
Wild Type Strain ◽  
Live Vaccine ◽  
Estrus Synchronization ◽  
Wild Type ◽  
Vaccine Candidates ◽  
Naturally Occurring ◽  
Virulence Attenuation ◽  
Humoral Antibodies ◽  
Vaccine Potential

ABSTRACT Three live vaccine candidates of Salmonella enterica subspecies I serotype Abortusovis (aroA, cya crp cdt, and plasmid-cured strains) have been developed, and their efficacies in inducing humoral antibodies and protecting against abortion after challenge with wild-type strain SS44 were evaluated in sheep. Following estrus synchronization, animals were immunized 3 weeks after fertilization and boosted once 3 weeks later. Following challenge with wild-type SS44, pregnancy failure of vaccinated ewes was reduced compared to that of nonimmunized controls. Attenuation of each vaccine was also assessed in challenge experiments with nonimmunized pregnant ewes and in BALB/c mice. All three vaccine candidates appear to be safe for use in sheep and provide a model for the development of live vaccine candidates against naturally occurring ovine salmonellosis.

Effect of the duration of Schistosoma mansoni infections on the degree of protection against subsequent exposures

1963 ◽  
Vol 57 (5) ◽  
pp. 375-378 ◽  
Author(s):  
Lawrence S. Ritchie ◽  
Lyman P. Frick ◽  
Wilda B. Knight ◽  
Luis A. Berrios-Duran
Keyword(s):  
Schistosoma Mansoni ◽  
Degree Of Protection

Influence of pattern of exposure, parasite genetic diversity and sex on the degree of protection against reinfection with Schistosoma mansoni

2007 ◽  
Vol 101 (2) ◽  
pp. 247-252 ◽  
Author(s):  
M. Dumont ◽  
H. Moné ◽  
G. Mouahid ◽  
M. A. Idris ◽  
M. Shaban ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Schistosoma Mansoni ◽  
Degree Of Protection

Induction of protective immunity and modulation of granulomatous hypersensitivity in mice using PIII, an anionic fraction of Schistosoma mansoni adult worm

Parasitology ◽  
1997 ◽  
Vol 115 (1) ◽  
pp. 21-28 ◽  
Author(s):  
C. HIRSCH ◽  
C. S. ZOUAIN ◽  
J. B. ALVES ◽  
A. M. GOES
Keyword(s):  
Schistosoma Mansoni ◽  
Adult Worm ◽  
Protective Immunity ◽  
Anion Exchange Chromatography ◽  
Significant Degree ◽  
Exchange Chromatography ◽  
Portal System ◽  
Degree Of Protection ◽  
Proliferation Assays ◽  
Adult Worm Antigen

This study was performed in order to define Schistosoma mansoni antigens that are able to function as modulator agents in the granulomatous hypersensitivity to parasite eggs in BALB/c and C57BL/6 mice. A fraction of S. mansoni, designated PIII, derived from adult worm antigen preparation (SWAP) was obtained using anion-exchange chromatography on an FPLC system. Immunization of mice with PIII in the presence of Corynebacterium parvum and Al(OH)3 as adjuvant induced an immune response in these animals as determined by ELISA and spleen cell proliferation assays against S. mansoni antigens SEA, SWAP and PIII. In addition, PIII caused a significant degree of protection against a challenge infection in immunized mice as observed by the decrease on worm burden recovered from the portal system. We also showed that PIII profoundly inhibited the vigorous anamnestic granulomatous response to eggs in the liver and lungs. This suppression correlated with a significant decrease in granuloma size. From these results we conclude that the PIII preparation contains antigens that can mediate protective anti-parasite immunity and downregulate granulomatous hypersensitivity to S. mansoni eggs.

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