scholarly journals Chondromyxoid fibroma of skull base: a tumour prone to local recurrence

1999 ◽  
Vol 113 (4) ◽  
pp. 380-385 ◽  
Author(s):  
T. W. H. Shek ◽  
W. C. G. Peh ◽  
G. Leung
Keyword(s):  
Skull Base ◽  
Chondromyxoid Fibroma ◽  
Cell Type ◽  
Initial Operation ◽  
Biological Behaviour ◽  
Nasal Symptoms ◽  
Original Tumour ◽  
Fibroblastic Cells ◽  
Histological Morphology ◽  
Histological Progression

AbstractChondromyxoid fibroma of the skull base is extremely uncommon. Sometimes involvement of the nasal cavity may occur and the patients may present with nasal symptoms. The biological behaviour of this tumour has not been well studied, primarily because of the limited number of reported cases and the short duration of followup. We report a histologically confirmed case of chondromyxoid fibroma of the skull base that recurred repeatedly over a 10-year period after the initial operation. Histologically it showed identical morphology to the original tumour with no evidence of histological progression or dedifferentiation. Ultrastructurally, the spindle tumour cells in the fibromyxoid area showed dual chondroblastic and fibroblastic differentiation, suggesting that these spindle fibroblastic cells and the better differentiated chondroid cells were of the same cell type with different histological morphology.

Chondromyxoid fibroma of the skull base☆☆☆★

1998 ◽  
Vol 118 (3) ◽  
pp. 415-418 ◽  
Author(s):  
J PATINOCORDOBA ◽  
J TURNER ◽  
S MCCARTHY ◽  
P FAGAN
Keyword(s):  
Skull Base ◽  
Chondromyxoid Fibroma

CYCLIC AMP AND THE DIFFERENTIATION OF ADRENAL CORTICAL CELLS GROWN IN TISSUE CULTURE

1972 ◽  
Vol 55 (2) ◽  
pp. 405-413 ◽  
Author(s):  
A. JOSEPHINE MILNER
Keyword(s):  
Cyclic Amp ◽  
Smooth Endoplasmic Reticulum ◽  
Synthetic Activity ◽  
Cell Type ◽  
Cortical Cells ◽  
Steroid Synthesis ◽  
Adrenal Cells ◽  
Adrenal Cortical Cells ◽  
Primary Tissue ◽  
Fibroblastic Cells

SUMMARY Primary tissue cultures of adrenal cells were prepared from foetal rat adrenals. The effect of cyclic AMP (75 μmol/l) on the morphology and steroid synthetic activity of the cortical cells was examined in order to determine whether cyclic AMP mimics the effects induced by adrenocorticotrophin (ACTH); namely transformation to the differentiated cell type and increase in steroid synthetic activity. Cyclic AMP was found to induce some, but not all, of the changes normally induced by ACTH. In particular, the mitochondria in the cortical cells developed vesicular cristae and there was a proliferation of the smooth endoplasmic reticulum. These two organelles are the principle sites of enzymes involved in steroid synthesis and the ultrastructural transformation was accompanied by an increase in the steroidogenic activity of the cells. However, clear differences in the ultrastructure of the cyclic AMP- and ACTH-treated cells were noted. The effects of cyclic AMP on the ultrastructure of cortical and fibroblastic cells present in the adrenal cultures were found to be dependent upon the cell type.

Defining the “edge of the envelope”: patient selection in treating complex sellar-based neoplasms via transsphenoidal versus open craniotomy

2011 ◽  
Vol 114 (2) ◽  
pp. 286-300 ◽  
Author(s):  
Gabriel Zada ◽  
Rose Du ◽  
Edward R. Laws
Keyword(s):  
Skull Base ◽  
Perioperative Complications ◽  
Extent Of Resection ◽  
Definitive Treatment ◽  
Tumor Characteristics ◽  
Sellar Region ◽  
Lateral Extension ◽  
Initial Operation ◽  
Brain Invasion ◽  
Tumor Consistency

Object Endonasal approaches have become the gold standard intervention for many anterior and middle skull base tumors. The authors aimed to define some of the existing limitations of these approaches by reviewing their experience with complex sellar region tumors that were initially considered for both transsphenoidal and open skull base approaches and were thus deemed tumors at “the edge of the envelope.” Methods Between April 2008 and April 2010, 250 transsphenoidal operations were performed at Brigham and Women's Hospital. All cases were retrospectively reviewed to identify patients with complex sellar region tumors that were initially considered for, or soon thereafter required, an open craniotomy as the definitive treatment. The anatomical tumor characteristics that posed limitations to performing safe and effective endonasal skull base operations were reviewed. Results Thirteen cases exemplifying some of the existing limitations to achieving optimal surgical outcomes via transsphenoidal-based approaches are presented. The following 8 factors are separately discussed that repeatedly limited the extent of resection, increased the risk of the operation, and contributed to perioperative complications: significant suprasellar extension, lateral extension, retrosellar extension, brain invasion with edema, firm tumor consistency, involvement or vasospasm of the arteries of the circle of Willis, and encasement of the optic apparatus or invasion of the optic foramina. Conclusions Although the ability to approach and resect complex tumors using endonasal skull base techniques has evolved dramatically in recent years, several inherent tumor characteristics mandate extensive preoperative consideration. In selected cases these characteristics may lend support to selecting an open craniotomy as the initial operation.

Skull Base Chondromyxoid Fibroma: A Case Report and Review of the Literature

2021 ◽  
Author(s):  
Christopher Weeks ◽  
Ya Xu ◽  
Ali Jalali ◽  
Kelly Gallagher
Keyword(s):  
Case Report ◽  
Skull Base ◽  
Chondromyxoid Fibroma ◽  
Review Of The Literature

Skull base chordoma mimicking a preauricular neoplasm in a child: Clinicopathological features and biological behaviour

2007 ◽  
Vol 35 (1) ◽  
pp. 35-38 ◽  
Author(s):  
Zsuzsanna Suba ◽  
Péter Hauser ◽  
Miklós Garami ◽  
Katalin Martonffy ◽  
György Szabó ◽  
...  
Keyword(s):  
Skull Base ◽  
Clinicopathological Features ◽  
Biological Behaviour ◽  
Skull Base Chordoma

Chondromyxoid Fibroma of the Skull Base: A Tumor Which May Be Confused with Chordoma and Chondrosarcoma

1997 ◽  
Vol 21 (5) ◽  
pp. 577-582 ◽  
Author(s):  
Suzanne B. Keel ◽  
Atul K. Bhan ◽  
Norbert J. Liebsch ◽  
Andrew E. Rosenberg
Keyword(s):  
Skull Base ◽  
Chondromyxoid Fibroma

scholarly journals Tumour-to-tumour metastasis: breast carcinoma to an olfactory neuroblastoma

2020 ◽  
Vol 102 (6) ◽  
pp. e118-e121 ◽  
Author(s):  
A Bashyam ◽  
V Grammatopoulou ◽  
T Crook ◽  
S Di Palma ◽  
VS Sunkaraneni
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Head And Neck ◽  
Skull Base ◽  
Primary Tumour ◽  
Distant Metastases ◽  
Olfactory Neuroblastoma ◽  
Endoscopic Polypectomy ◽  
Tumour Metastasis ◽  
Nasal Symptoms

Tumour-to-tumour metastasis is a rare phenomenon. It occurs when a primary tumour is a recipient of a separate tumour within the same individual. We present a case of a 66-year-old woman with known breast cancer who presented with one-sided nasal symptoms. Examination and imaging revealed a unilateral polyp arising from the skull base. She underwent endoscopic polypectomy with the histology demonstrating tumour-to-tumour metastasis from a breast carcinoma to an olfactory neuroblastoma, a rare sinonasal tumour. Clinicians should be cautious of distant metastases in any patient presenting with head and neck symptoms and a known primary tumour. This is the first documented case of this type.

Chondromyxoid fibroma of the skull base: Differential diagnosis and radiotherapy. Two case reports and a review of the literature

2005 ◽  
Vol 44 (6) ◽  
pp. 545-553 ◽  
Author(s):  
Loïc Feuvret ◽  
Georges Noël ◽  
Valentin Calugaru ◽  
Philippe Terrier ◽  
Jean-Louis Habrand
Keyword(s):  
Differential Diagnosis ◽  
Skull Base ◽  
Case Reports ◽  
Chondromyxoid Fibroma ◽  
Review Of The Literature
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