Management of sarcomatoid salivary duct carcinoma of the submandibular gland duct with coexisting seropositive human immunodeficiency virus

2013 ◽  
Vol 127 (6) ◽  
pp. 621-624
Author(s):  
W F Mourad ◽  
K S Hu ◽  
R A Shourbaji ◽  
L B Harrison
Keyword(s):  
Computed Tomography ◽  
Submandibular Gland ◽  
Adjuvant Radiotherapy ◽  
Salivary Duct Carcinoma ◽  
Emission Tomography ◽  
Salivary Duct ◽  
Duct Carcinoma ◽  
Positron Emission ◽  
Immunodeficiency Virus ◽  
Gland Duct

AbstractBackground:Sarcomatoid salivary duct carcinoma of the submandibular gland is extremely rare. This paper highlights the impact of surgery and adjuvant radiation therapy on the outcome of this disease.Methods:A 59-year-old man with human immunodeficiency virus presented with a painless, rapidly growing left neck mass. Biopsy followed by surgical excision of the left submandibular gland revealed sarcomatoid salivary duct carcinoma of the submandibular gland duct with perineural invasion and close margins, for which he underwent adjuvant radiotherapy. Post-operative positron emission tomography and computed tomography revealed no residual or metastatic disease. Pathological analysis of tumour–node–metastasis staging revealed a T2 N0 M0 (stage II) tumour.Results:The patient tolerated his treatment without serious acute or long-term side effects. There was no evidence of disease on comprehensive examination or on positron emission tomography or computed tomography scans at the 4.6-year follow up.Conclusion:Surgery followed by adjuvant radiotherapy provided practical locoregional control with acceptable toxicity. Further detailed case reports are warranted to optimise the management of this rare malignancy.

Salivary duct carcinoma of submandibular gland with trigeminal nerve invasion to intracranium

2003 ◽  
Vol 117 (9) ◽  
pp. 731-733 ◽  
Author(s):  
Chia-Hug Li ◽  
Chih-Ying Su ◽  
Chih-Yen Chien ◽  
Chung-Feng Hwang ◽  
Hsiu-Yu Huang
Keyword(s):  
Submandibular Gland ◽  
Trigeminal Nerve ◽  
Distant Metastasis ◽  
Perineural Invasion ◽  
Radical Resection ◽  
Malignant Tumour ◽  
Salivary Duct Carcinoma ◽  
Salivary Duct ◽  
Duct Carcinoma ◽  
Dismal Prognosis

Salivary duct carcinoma is a rare and invasive malignant tumour with rapid distant metastasis and dismal prognosis. Clinically, perineural invasion of the salivary duct carcinoma is commonly noted. Here, we present a case of salivary duct carcinoma of submandibular gland origin with perineural invasion of the trigeminal nerve proximal to the intracranium, that was well demonstrated by a magnetic resonance image (MRI) and was consistent with the clinical presentation. This case received radical resection and radiotherapy with inclusion of the skull base within the field. There was no tumour recurrence and distant metastasis 24 months post-operatively.

Salivary Duct Carcinoma in the Submandibular Gland; A Report of Two Cases

2003 ◽  
Vol 96 (5) ◽  
pp. 411-415 ◽  
Author(s):  
Tatsuhisa Hasegawa ◽  
Masakatsu Taki ◽  
Itaru Yamamichi ◽  
Hirofumi Sakaguchi ◽  
Hiroshi Nakano ◽  
...  
Keyword(s):  
Submandibular Gland ◽  
Salivary Duct Carcinoma ◽  
Salivary Duct ◽  
Duct Carcinoma

A Case of Submandibular Gland Salivary Duct Carcinoma

2010 ◽  
Vol 103 (7) ◽  
pp. 651-655
Author(s):  
Eiju Kanagawa ◽  
Osamu Horiike ◽  
Kazuma Sugahara ◽  
Hiroshi Yamashita
Keyword(s):  
Submandibular Gland ◽  
Salivary Duct Carcinoma ◽  
Salivary Duct ◽  
Duct Carcinoma

A Case of Salivary Duct Carcinoma in the Submandibular Gland Treated Long-term with a Combination of Trastuzumab and Docetaxel

2018 ◽  
Vol 152 (0) ◽  
pp. 90-91
Author(s):  
Saki Yabuuchi ◽  
Shinji Takebayashi ◽  
Mai Nakahira ◽  
Yuki Tanigami ◽  
Yasuyuki Hayashi ◽  
...  
Keyword(s):  
Submandibular Gland ◽  
Salivary Duct Carcinoma ◽  
Salivary Duct ◽  
Duct Carcinoma

Sarcomatoid Salivary Duct Carcinoma of the Submandibular Gland

2010 ◽  
Vol 54 (5) ◽  
pp. 695-700 ◽  
Author(s):  
Masaki Mori ◽  
Makoto Ohta ◽  
Hideki Maegawa ◽  
Toshie Hara ◽  
Yoshiaki Imamura
Keyword(s):  
Submandibular Gland ◽  
Salivary Duct Carcinoma ◽  
Salivary Duct ◽  
Duct Carcinoma

scholarly journals [68Ga]Ga-Pentixafor for PET Imaging of Vascular Expression of CXCR-4 as a Marker of Arterial Inflammation in HIV-Infected Patients: A Comparison with 18F[FDG] PET Imaging

Biomolecules ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1629
Author(s):  
Ismaheel O. Lawal ◽  
Gbenga O. Popoola ◽  
Johncy Mahapane ◽  
Jens Kaufmann ◽  
Cindy Davis ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Fdg Pet ◽  
Emission Tomography ◽  
Positron Emission ◽  
Pet Ct ◽  
Immunodeficiency Virus ◽  
Arterial Inflammation ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Level Of Agreement

People living with human immunodeficiency virus (PLHIV) have excess risk of atherosclerotic cardiovascular disease (ASCVD). Arterial inflammation is the hallmark of atherogenesis and its complications. In this study we aimed to perform a head-to-head comparison of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG PET/CT) and Gallium-68 pentixafor positron emission tomography/computed tomography [68Ga]Ga-pentixafor PET/CT for quantification of arterial inflammation in PLHIV. We prospectively recruited human immunodeficiency virus (HIV)-infected patients to undergo [18F]FDG PET/CT and [68Ga]Ga-pentixafor PET/CT within two weeks of each other. We quantified the levels of arterial tracer uptake on both scans using maximum standardized uptake value (SUVmax) and target–background ratio. We used Bland and Altman plots to measure the level of agreement between tracer quantification parameters obtained on both scans. A total of 12 patients were included with a mean age of 44.67 ± 7.62 years. The mean duration of HIV infection and mean CD+ T-cell count of the study population were 71.08 ± 37 months and 522.17 ± 260.33 cells/µL, respectively. We found a high level of agreement in the quantification variables obtained using [18F]FDG PET and [68Ga]Ga-pentixafor PET. There is a good level of agreement in the arterial tracer quantification variables obtained using [18F]FDG PET/CT and [68Ga]Ga-pentixafor PET/CT in PLHIV. This suggests that [68Ga]Ga-pentixafor may be applied in the place of [18F]FDG PET/CT for the quantification of arterial inflammation.

The Role of Positron Emission Tomography/Computed Tomography in Planning Radiotherapy in Endometrial Cancer

2015 ◽  
Vol 25 (4) ◽  
pp. 645-649 ◽  
Author(s):  
Bryony Simcock ◽  
Kailash Narayan ◽  
Elizabeth Drummond ◽  
David Bernshaw ◽  
Elizabeth Wells ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Endometrial Cancer ◽  
Adjuvant Radiotherapy ◽  
Emission Tomography ◽  
Optimal Method ◽  
Positron Emission ◽  
Pet Ct ◽  
High Risk Disease

ObjectiveThe optimal method of assessing disease distribution in endometrial cancer is widely debated. Knowledge of disease distribution assists in planning adjuvant radiotherapy; in this study we used positron emission tomography/computed tomography (PET/CT) to assess disease distribution before radiotherapy.MethodsSeventy-three consecutive patients referred to the Peter MacCallum Cancer Centre for adjuvant radiotherapy for endometrial cancer, with either high-risk disease after a hysterectomy or recurrent disease, had a PET/CT before treatment. The findings on PET/CT and clinical course were recorded.ResultsPET/CT found additional disease in 35% of postoperative patients, changing planned treatment in 31%. In the group with known recurrence, additional disease was found in 72%, changing management in 36%.ConclusionsPET/CT is a valuable tool for planning radiotherapy in endometrial cancer.

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