Polyps, grommets and eosinophilic granulomatosis with polyangiitis

2018 ◽  
Vol 132 (3) ◽  
pp. 236-239 ◽  
Author(s):  
F G Kavanagh ◽  
W Hasan ◽  
D A Smyth ◽  
J E Fenton
Keyword(s):  
Observational Study ◽  
Diagnostic Criteria ◽  
Otitis Media ◽  
Nasal Polyps ◽  
Nasal Polyposis ◽  
Granulomatosis With Polyangiitis ◽  
Otitis Media With Effusion ◽  
Eosinophilic Granulomatosis With Polyangiitis ◽  
The Mean ◽  
Eosinophilic Granulomatosis

AbstractObjective:To explore the link between nasal polyposis, refractory otitis media with effusion and eosinophilic granulomatosis with polyangiitis.Methods:A retrospective observational study was carried out of patients diagnosed with refractory otitis media with effusion necessitating grommet insertion and who had nasal polyps. Patients were evaluated to determine if they fulfilled the diagnostic criteria of eosinophilic granulomatosis with polyangiitis.Results:Sixteen patients (10 males and 6 females) were identified. The mean age of grommet insertion was 45.4 years. The mean number of grommets inserted per patient was 1.6. The mean number of nasal polypectomies was 1.7. All 16 patients had paranasal sinus abnormalities and otitis media with effusion, 14 had asthma, 9 had serological eosinophilia and 7 had extravascular eosinophilia. Nine patients met the diagnostic criteria for eosinophilic granulomatosis with polyangiitis.Conclusion:The co-presence of nasal polyps and resistant otitis media with effusion should raise the possibility of eosinophilic granulomatosis with polyangiitis.

scholarly journals Effects of surgery and topical medication on eosinophilic granulomatosis with polyangiitis with otitis media and sinusitis: a case report

2020 ◽  
Vol 48 (4) ◽  
pp. 030006052092004
Author(s):  
Zijing Wang ◽  
Lin Han ◽  
Lisheng Yu
Keyword(s):  
Otitis Media ◽  
Granulomatosis With Polyangiitis ◽  
Otitis Media With Effusion ◽  
Granulomatous Inflammation ◽  
Sinus Surgery ◽  
High Dose ◽  
Eosinophilic Granulomatosis With Polyangiitis ◽  
Strauss Syndrome ◽  
Ear Symptoms ◽  
Eosinophilic Granulomatosis

Eosinophilic granulomatosis with polyangiitis (EGPA), also known as Churg–Strauss syndrome, is eosinophil-rich, necrotizing granulomatous inflammation often involving the respiratory tract. Furthermore, EGPA is necrotizing vasculitis that predominantly affects small to medium vessels and is associated with asthma and eosinophilia. Most patients with EGPA have sinusitis and some complain of hearing loss and refractory otitis media with effusion. Systemic use of immunosuppressants and glucocorticoids is currently recommended, despite the inevitable associated side effects. However, systemic treatment is not always effective for nasal and ear symptoms. We report a case of EGPA with refractory otitis media and chronic sinusitis, which were resistant to systemic high-dose steroids and immunosuppressants. However, these symptoms responded well to functional endoscopic sinus surgery and myringotomy and grommet insertion. We also administered budesonide nasal irrigation and glucocorticoid injection by intratympanic and postaural methods in this patient. The therapeutic effect was satisfactory.

Differentiation Between Eosinophilic Otitis Media and Otitis Media Associated With Eosinophilic Granulomatosis With Polyangiitis

2019 ◽  
Vol 40 (8) ◽  
pp. e796-e802 ◽  
Author(s):  
Atsushi Fukuda ◽  
Shinya Morita ◽  
Yuji Nakamaru ◽  
Kimiko Hoshino ◽  
Keishi Fujiwara ◽  
...  
Keyword(s):  
Otitis Media ◽  
Granulomatosis With Polyangiitis ◽  
Eosinophilic Granulomatosis With Polyangiitis ◽  
Eosinophilic Granulomatosis

Nasal polyps in eosinophilic granulomatosis with polyangiitis: Structured histopathology and CD105 expression

2020 ◽  
Vol 41 (6) ◽  
pp. 102661 ◽  
Author(s):  
Giuseppe Brescia ◽  
Roberto Padoan ◽  
Franco Schiavon ◽  
Giacomo Contro ◽  
Daniela Parrino ◽  
...  
Keyword(s):  
Nasal Polyps ◽  
Granulomatosis With Polyangiitis ◽  
Eosinophilic Granulomatosis With Polyangiitis ◽  
Eosinophilic Granulomatosis

scholarly journals Eosinophilic Granulomatosis with Polyangiitis Presenting with Myocarditis as an Initial Symptom: A Case Report and Review of the Literature

2021 ◽  
pp. 329-333
Author(s):  
Kanako Kurihara ◽  
Jun Tsugawa ◽  
Shinji Ouma ◽  
Toshiyasu Ogata ◽  
Mikiko Aoki ◽  
...  
Keyword(s):  
Granulomatosis With Polyangiitis ◽  
Nerve Biopsy ◽  
Pulse Therapy ◽  
Sural Nerve Biopsy ◽  
Lower Limbs ◽  
Rapid Progression ◽  
Eosinophilic Granulomatosis With Polyangiitis ◽  
Initial Symptom ◽  
Steroid Pulse ◽  
Eosinophilic Granulomatosis

A 66-year-old woman with a history of bronchial asthma had shortness of breath and fatigue upon mild exercise. She was diagnosed as congestive heart failure. A blood test showed eosinophilia without the presence of anti-neutrophil cytoplasmic antibody (ANCA), and a myocardial biopsy specimen revealed eosinophilic infiltration in the myocardium. Eosinophilia was improved when she was administered short-term methylprednisolone. After that, she had numbness and pain in her lower limbs with re-elevation of eosinophils. She had dysesthesia and hypalgesia in the distal part of the limbs. Sural nerve biopsy revealed axonal degeneration and thickness of the arterial wall, indicating a diagnosis of eosinophilic granulomatosis with polyangiitis (EGPA). Two courses of steroid pulse therapy were performed, resulting in marked improvement of her sensory symptoms. ANCA-negative EGPA might be associated with myocarditis and peripheral neuropathy. A sufficient immunotherapy should have been considered to prevent rapid progression.

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