scholarly journals A model-adjusted space–time scan statistic with an application to syndromic surveillance

2005 ◽  
Vol 133 (3) ◽  
pp. 409-419 ◽  
Author(s):  
K. P. KLEINMAN ◽  
A. M. ABRAMS ◽  
M. KULLDORFF ◽  
R. PLATT

The space–time scan statistic is often used to identify incident disease clusters. We introduce a method to adjust for naturally occurring temporal trends or geographical patterns in illness. The space–time scan statistic was applied to reports of lower respiratory complaints in a large group practice. We compared its performance with unadjusted populations from: (1) the census, (2) group-practice membership counts, and on adjustments incorporating (3) day of week, month, and holidays; and (4) additionally, local history of illness. Using a nominal false detection rate of 5%, incident clusters during 1 year were identified on 26, 22, 4 and 2% of days for the four populations respectively. We show that it is important to account for naturally occurring temporal and geographic trends when using the space–time scan statistic for surveillance. The large number of days with clusters renders the census and membership approaches impractical for public health surveillance. The proposed adjustment allows practical surveillance.

Author(s):  
Kinley Wangdi ◽  
Kinley Penjor ◽  
Tobgyal ◽  
Saranath Lawpoolsri ◽  
Ric N. Price ◽  
...  

Malaria in Bhutan has fallen significantly over the last decade. As Bhutan attempts to eliminate malaria in 2022, this study aimed to characterize the space–time clustering of malaria from 2010 to 2019. Malaria data were obtained from the Bhutan Vector-Borne Disease Control Program data repository. Spatial and space–time cluster analyses of Plasmodium falciparum and Plasmodium vivax cases were conducted at the sub-district level from 2010 to 2019 using Kulldorff’s space–time scan statistic. A total of 768 confirmed malaria cases, including 454 (59%) P. vivax cases, were reported in Bhutan during the study period. Significant temporal clusters of cases caused by both species were identified between April and September. The most likely spatial clusters were detected in the central part of Bhutan throughout the study period. The most likely space–time cluster was in Sarpang District and neighboring districts between January 2010 to June 2012 for cases of infection with both species. The most likely cluster for P. falciparum infection had a radius of 50.4 km and included 26 sub-districts with a relative risk (RR) of 32.7. The most likely cluster for P. vivax infection had a radius of 33.6 km with 11 sub-districts and RR of 27.7. Three secondary space–time clusters were detected in other parts of Bhutan. Spatial and space–time cluster analysis identified high-risk areas and periods for both P. vivax and P. falciparum malaria. Both malaria types showed significant spatial and spatiotemporal variations. Operational research to understand the drivers of residual transmission in hotspot sub-districts will help to overcome the final challenges of malaria elimination in Bhutan.


2018 ◽  
Vol 46 (1) ◽  
pp. 142-159 ◽  
Author(s):  
Benjamin Allévius ◽  
Michael Höhle

2020 ◽  
Vol 12 (1) ◽  
pp. 27-33
Author(s):  
Alexander Hohl ◽  
Eric Delmelle ◽  
Michael Desjardins

Biometrics ◽  
2010 ◽  
Vol 67 (1) ◽  
pp. 106-115 ◽  
Author(s):  
Toshiro Tango ◽  
Kunihiko Takahashi ◽  
Kazuaki Kohriyama
Keyword(s):  

2020 ◽  
Vol 34 ◽  
pp. 100354 ◽  
Author(s):  
Alexander Hohl ◽  
Eric M. Delmelle ◽  
Michael R. Desjardins ◽  
Yu Lan

1998 ◽  
Vol 88 (9) ◽  
pp. 1377-1380 ◽  
Author(s):  
M Kulldorff ◽  
W F Athas ◽  
E J Feurer ◽  
B A Miller ◽  
C R Key

2018 ◽  
Vol 46 (6) ◽  
pp. 647-658 ◽  
Author(s):  
Mohammadreza Rajabi ◽  
Ali Mansourian ◽  
Petter Pilesjö ◽  
Daniel Oudin Åström ◽  
Klas Cederin ◽  
...  

Aims: Cardiovascular disease (CVD) is one of the leading causes of mortality and morbidity worldwide, including in Sweden. The main aim of this study was to explore the temporal trends and spatial patterns of CVD in Sweden using spatial autocorrelation analyses. Methods: The CVD admission rates between 2000 and 2010 throughout Sweden were entered as the input disease data for the analytic processes performed for the Swedish capital, Stockholm, and also for the whole of Sweden. Age-adjusted admission rates were calculated using a direct standardisation approach for men and women, and temporal trends analysis were performed on the standardised rates. Global Moran’s I was used to explore the structure of patterns and Anselin’s local Moran’s I, together with Kulldorff’s scan statistic were applied to explore the geographical patterns of admission rates. Results: The rates followed a spatially clustered pattern in Sweden with differences occurring between sexes. Accordingly, hot spots were identified in northern Sweden, with higher intensity identified for men, together with clusters in central Sweden. Cold spots were identified in the adjacency of the three major Swedish cities of Stockholm, Gothenburg and Malmö. Conclusions: The findings of this study can serve as a basis for distribution of health-care resources, preventive measures and exploration of aetiological factors.


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