scholarly journals Semantic and lexical features of words dissimilarly affected by non-fluent, logopenic, and semantic primary progressive aphasia

2019 ◽  
Vol 25 (10) ◽  
pp. 1011-1022 ◽  
Author(s):  
Jet M. J. Vonk ◽  
Roel Jonkers ◽  
H. Isabel Hubbard ◽  
Maria Luisa Gorno-Tempini ◽  
Adam M. Brickman ◽  
...  
Keyword(s):  
Semantic Processing ◽  
Mental Lexicon ◽  
Primary Progressive Aphasia ◽  
Word Form ◽  
Lexical Frequency ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Lexical Semantic ◽  
Psycholinguistic Variables

AbstractObjective:To determine the effect of three psycholinguistic variables—lexical frequency, age of acquisition (AoA), and neighborhood density (ND)—on lexical-semantic processing in individuals with non-fluent (nfvPPA), logopenic (lvPPA), and semantic primary progressive aphasia (svPPA). Identifying the scope and independence of these features can provide valuable information about the organization of words in our mind and brain.Method:We administered a lexical decision task—with words carefully selected to permit distinguishing lexical frequency, AoA, and orthographic ND effects—to 41 individuals with PPA (13 nfvPPA, 14 lvPPA, 14 svPPA) and 25 controls.Results:Of the psycholinguistic variables studied, lexical frequency had the largest influence on lexical-semantic processing, but AoA and ND also played an independent role. The results reflect a brain-language relationship with different proportional effects of frequency, AoA, and ND in the PPA variants, in a pattern that is consistent with the organization of the mental lexicon. Individuals with nfvPPA and lvPPA experienced an ND effect consistent with the role of inferior frontal and temporoparietal regions in lexical analysis and word form processing. By contrast, individuals with svPPA experienced an AoA effect consistent with the role of the anterior temporal lobe in semantic processing.Conclusions:The findings are in line with a hierarchical mental lexicon structure with a conceptual (semantic) and a lexeme (word-form) level, such that a selective deficit at one of these levels of the mental lexicon manifests differently in lexical-semantic processing performance, consistent with the affected language-specific brain region in each PPA variant.

scholarly journals Insights into lexical-semantic processing from not only semantic but also non-fluent and logopenic primary progressive aphasia

2017 ◽  
Vol 11 ◽  
Author(s):  
Jet M. J. Vonk ◽  
Maria Luisa Gorno-Tempini ◽  
H. Isabel Hubbard ◽  
Roel Jonkers ◽  
Adam Brickman ◽  
...  
Keyword(s):  
Semantic Processing ◽  
Primary Progressive Aphasia ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Lexical Semantic

scholarly journals The role of the hippocampus in the semantic variant of primary progressive aphasia: A resting‐state fcMRI study

Hippocampus ◽  
2019 ◽  
Vol 29 (11) ◽  
pp. 1127-1132
Author(s):  
Marianne Chapleau ◽  
Maxime Montembeault ◽  
Mariem Boukadi ◽  
Christophe Bedetti ◽  
Robert Laforce ◽  
...  
Keyword(s):  
Resting State ◽  
Primary Progressive Aphasia ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Semantic Variant

scholarly journals Behavioral and Pharmacological Treatment of Lexical-Semantic Deficits in a Single Patient With Primary Progressive Aphasia

1995 ◽  
Vol 4 (4) ◽  
pp. 76-87 ◽  
Author(s):  
Malcolm R. McNeil ◽  
Steven L. Small ◽  
Robert J. Masterson ◽  
Tepanta R. D. Fossett
Keyword(s):  
Pharmacological Treatment ◽  
Behavioral Treatment ◽  
Primary Progressive Aphasia ◽  
Lexical Retrieval ◽  
Baseline Design ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Lexical Semantic ◽  
Positive Effects ◽  
Extended Practice

In the context of a hybrid multiple-baseline design, this study demonstrated the positive effects of a behavioral + pharmacological (dextroamphetamine) treatment for lexical-semantic deficits in an individual with primary progressive aphasia (PPA). Behavioral treatment entailed application of a cuing hierarchy to predicative adjectives in order to facilitate lexical retrieval. Treatment was effective for both antonym and synonym adjectives, although extended practice was required to achieve criterion. Generalization to nontreated adjectives, verbs, and prepositions was observed, and maintenance was difficult to disambiguate from the progressive nature of the disease. It was proposed that the mechanisms of activation and inhibition were responsible for improved performance. Differential effects between behavioral and behavioral + pharmacological treatment were not observed.

scholarly journals Middle longitudinal fascicle is associated with semantic processing deficits in primary progressive aphasia

2020 ◽  
Vol 25 ◽  
pp. 102115 ◽  
Author(s):  
Chunyan Luo ◽  
Sara Makaretz ◽  
Michael Stepanovic ◽  
George Papadimitriou ◽  
Megan Quimby ◽  
...  
Keyword(s):  
Semantic Processing ◽  
Primary Progressive Aphasia ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Processing Deficits ◽  
Middle Longitudinal Fascicle

scholarly journals Language training for oral and written naming impairment in primary progressive aphasia: a review

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Ilaria Pagnoni ◽  
Elena Gobbi ◽  
Enrico Premi ◽  
Barbara Borroni ◽  
Giuliano Binetti ◽  
...  
Keyword(s):  
Semantic Processing ◽  
Neurodegenerative Disorder ◽  
Processing System ◽  
Primary Progressive Aphasia ◽  
Main Body ◽  
Language Training ◽  
Language Abilities ◽  
Large Variability ◽  
Progressive Aphasia ◽  
Primary Progressive

Abstract Background Primary progressive aphasia (PPA) is a neurodegenerative disorder characterized by a gradual, insidious and progressive loss of language abilities, with naming difficulties being an early and persistent impairment common to all three variants. In the absence of effective pharmacological treatments and given the progressive nature of the disorder, in the past few decades, many studies have investigated the effectiveness of language training to minimize the functional impact of word-finding difficulties in daily life. Main body We review language treatments most commonly used in clinical practice among patients with different variants of PPA, with a focus on the enhancement of spoken and written naming abilities. Generalization of gains to the ability to name untrained stimuli or to other language abilities and the maintenance of these results over time are also discussed. Forty-eight studies were included in this literature review, identifying four main types of language treatment: a) lexical retrieval treatment, b) phonological and/or orthographic treatment, c) semantic treatment, and d) a multimodality approach treatment. Overall, language training is able to induce immediate improvements of naming abilities in all variants of PPA. Moreover, despite the large variability among results, generalization and long-term effects can be recorded after the training. The reviewed studies also suggest that one factor that determines the choice of a particular approach is the compromised components of the lexical/semantic processing system. Conclusion The majority of studies have demonstrated improvements of naming abilities following language treatments. Given the progressive nature of PPA, it is essential to apply language treatment in the early stages of the disease.

scholarly journals The Role of Word Properties in Performance on Fluency Tasks in People with Primary Progressive Aphasia

2019 ◽  
Vol 68 (4) ◽  
pp. 1521-1534 ◽  
Author(s):  
Adrià Rofes ◽  
Vânia de Aguiar ◽  
Bronte Ficek ◽  
Haley Wendt ◽  
Kimberly Webster ◽  
...  
Keyword(s):  
Primary Progressive Aphasia ◽  
Progressive Aphasia ◽  
Primary Progressive
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