Multilayered Controlled Drug Release Silk Fibroin Nanofilm by Manipulating Secondary Structure

2018 ◽  
Vol 19 (7) ◽  
pp. 3096-3103 ◽  
Author(s):  
Moonhyun Choi ◽  
Daheui Choi ◽  
Jinkee Hong
Keyword(s):  
Secondary Structure ◽  
Drug Release ◽  
Silk Fibroin ◽  
Controlled Drug Release

scholarly journals Silk fibroin/chitosan/alginate multilayer membranes as a system for controlled drug release in wound healing

2020 ◽  
Vol 152 ◽  
pp. 803-811 ◽  
Author(s):  
Murilo Santos Pacheco ◽  
Gustavo Eiji Kano ◽  
Letícia de Almeida Paulo ◽  
Patricia Santos Lopes ◽  
Mariana Agostini de Moraes
Keyword(s):  
Wound Healing ◽  
Drug Release ◽  
Silk Fibroin ◽  
Controlled Drug Release ◽  
Multilayer Membranes

Effect of coagulation bath parameters on the morphology and absorption behavior of a skin–core filament based on biomedical polyurethane and native silk fibroin microparticles

2019 ◽  
Vol 90 (3-4) ◽  
pp. 460-468 ◽  
Author(s):  
Yan Zhuang ◽  
Han Wang ◽  
Linfeng Wang ◽  
Changjun Liu ◽  
Yuan Xu ◽  
...  
Keyword(s):  
Drug Release ◽  
Water Absorption ◽  
Silk Fibroin ◽  
Controlled Drug Release ◽  
Coagulation Bath ◽  
Wet Spinning ◽  
Electron Microscopy Analysis ◽  
Potential Applications ◽  
Spinning Process ◽  
Biomedical Polyurethane

This study investigates the effect of the constituents and temperature of a coagulation bath on the morphology and water absorption behavior of a skin–core filament, which has potential application in the field of controlled drug release, based on biomedical polyurethane (BPU) and native silk fibroin microparticles (NSFPs). BPU solution and BPU/NSFP blend solution were extruded from the cortex and core channel of a coaxial double injector into a coagulation bath with different constituents and at different temperatures to form filaments. Scanning electron microscopy analysis of the skin–core filament prepared by wet-spinning revealed that the addition of ethanol decreased the exchange speed between the solvent and non-solvent and led to the formation of micropores on the surface. Meanwhile, the interface between the cortex and core became pronounced and the water absorption capability of the filament decreased with increasing ethanol concentration in the coagulation bath. The high temperature of the coagulation bath also improved the exchange speed between the solvent and non-solvent; however, its effect on the morphology of the filament was weak. Thus, a skin–core filament with different morphologies and water absorption behaviors was fabricated by controlling the constituents and temperature of the coagulation bath during the wet-spinning process. This skin–core filament has potential applications in controlled drug release.

Effect of secondary structure change on drug release from silk fibroin films

2013 ◽  
Vol 172 (1) ◽  
pp. e52 ◽  
Author(s):  
Lin Ma ◽  
Qiaona Wei ◽  
Xi Huang ◽  
Yuxiao Wang
Keyword(s):  
Secondary Structure ◽  
Drug Release ◽  
Silk Fibroin ◽  
Structure Change

Silk fibroin membranes with self‐assembled globular structures for controlled drug release

2019 ◽  
Vol 137 (16) ◽  
pp. 48763 ◽  
Author(s):  
Bruno Thorihara Tomoda ◽  
Fulvio Gabriel Corazza ◽  
Marisa Masumi Beppu ◽  
Patricia Santos Lopes ◽  
Mariana Agostini Moraes
Keyword(s):  
Drug Release ◽  
Silk Fibroin ◽  
Controlled Drug Release ◽  
Self Assembled

scholarly journals An implantable and controlled drug-release silk fibroin nanofibrous matrix to advance the treatment of solid tumour cancers

Biomaterials ◽  
2016 ◽  
Vol 103 ◽  
pp. 33-43 ◽  
Author(s):  
Maobin Xie ◽  
Dejun Fan ◽  
Yufeng Chen ◽  
Zheng Zhao ◽  
Xiaowen He ◽  
...  
Keyword(s):  
Drug Release ◽  
Silk Fibroin ◽  
Solid Tumour ◽  
Controlled Drug Release
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