Equilibrium Solubility Measurement and Modeling of CO2 Absorption in Aqueous Blend of 2-(Diethyl amino) Ethanol and Ethylenediamine

2020 ◽  
Vol 65 (2) ◽  
pp. 523-531 ◽  
Author(s):  
Shailesh Kumar ◽  
Ritesh Padhan ◽  
Monoj Kumar Mondal
Keyword(s):  
Co2 Absorption ◽  
Equilibrium Solubility ◽  
Solubility Measurement

scholarly journals Harmonizing solubility measurement to lower inter-laboratory variance – progress of consortium of biopharmaceutical tools (CoBiTo) in Japan

ADMET & DMPK ◽  
2019 ◽  
Vol 7 (3) ◽  
pp. 183-195 ◽  
Author(s):  
Asami Ono ◽  
Naoya Matsumura ◽  
Takahiro Kimoto ◽  
Yoshiyuki Akiyama ◽  
Satoko Funaki ◽  
...  
Keyword(s):  
Shake Flask ◽  
Water Soluble ◽  
Equilibrium Solubility ◽  
Poorly Water Soluble Drugs ◽  
Solubility Measurement ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble ◽  
Proprietary Protocol

The purpose of the present study was to harmonize the protocol of equilibrium solubility measurements for poorly water-soluble drugs to lower inter-laboratory variance. The “mandatory” and “recommended” procedures for the shake-flask method were harmonized based on the knowledge and experiences of each company and information from the literature. The solubility of model drugs was measured by the harmonized protocol (HP) and the non-harmonized proprietary protocol of each company (nonHP). Albendazole, griseofulvin, dipyridamole, and glibenclamide were used as model drugs. When using the nonHP, the solubility values showed large inter-laboratory variance. In contrast, inter-laboratory variance was markedly reduced when using the HP.

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