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Discovery of a Biased Allosteric Modulator for Cannabinoid 1 Receptor: Preclinical Anti-Glaucoma Efficacy
Journal of Medicinal Chemistry
◽
10.1021/acs.jmedchem.1c00040
◽
2021
◽
Author(s):
Sumanta Garai
◽
Luciana M. Leo
◽
Anna-Maria Szczesniak
◽
Dow P. Hurst
◽
Peter C. Schaffer
◽
...
Keyword(s):
Allosteric Modulator
◽
Cannabinoid 1 Receptor
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References
Correction: Structural modeling and role of HAX-1 as a positive allosteric modulator of human serine protease HtrA2
Biochemical Journal
◽
10.1042/bcj-2019-0569_cor
◽
2020
◽
Vol 477
(2)
◽
pp. 459-459
Author(s):
Lalith K. Chaganti
◽
Shubhankar Dutta
◽
Raja Reddy Kuppili
◽
Mriganka Mandal
◽
Kakoli Bose
Keyword(s):
Serine Protease
◽
Structural Modeling
◽
Allosteric Modulator
◽
Positive Allosteric Modulator
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The effect of mGluR2 3 agonist, LY379268, and a mGluR4 positive allosteric modulator, VU0155041, on conditioned taste aversion
10.32469/10355/40222
◽
2013
◽
Author(s):
Diana Klakotskaia
Keyword(s):
Taste Aversion
◽
Conditioned Taste Aversion
◽
Allosteric Modulator
◽
Positive Allosteric Modulator
Download Full-text
Faculty Opinions recommendation of Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile).
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
◽
10.3410/f.725689130.793508968
◽
2015
◽
Author(s):
John Lowe
Keyword(s):
Drug Discovery
◽
Allosteric Modulator
◽
Negative Allosteric Modulator
◽
Class C
Download Full-text
Faculty Opinions recommendation of Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
◽
10.3410/f.725679098.793542278
◽
2018
◽
Author(s):
Bernard Le Foll
Keyword(s):
Cb1 Receptor
◽
Allosteric Modulator
◽
Cannabinoid Cb1 Receptor
◽
Negative Allosteric Modulator
Download Full-text
Faculty Opinions recommendation of An mGlu5-Positive Allosteric Modulator Rescues the Neuroplasticity Deficits in a Genetic Model of NMDA Receptor Hypofunction in Schizophrenia.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
◽
10.3410/f.726061211.793515244
◽
2016
◽
Author(s):
Leslie Iversen
Keyword(s):
Nmda Receptor
◽
Genetic Model
◽
Allosteric Modulator
◽
Positive Allosteric Modulator
Download Full-text
Faculty Opinions recommendation of A Phase 2A Trial of the Novel mGluR5-Negative Allosteric Modulator Dipraglurant for Levodopa-Induced Dyskinesia in Parkinson's Disease.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
◽
10.3410/f.726375502.793520446
◽
2016
◽
Author(s):
Joseph Jankovic
◽
Mary Ann Thenganatt
Keyword(s):
Parkinson’S Disease
◽
Parkinson's Disease
◽
Allosteric Modulator
◽
The Novel
◽
Negative Allosteric Modulator
Download Full-text
Faculty Opinions recommendation of Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano-1H-pyrazol-1'-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid)A Receptor.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
◽
10.3410/f.727847766.793560292
◽
2019
◽
Author(s):
Hanns Möhler
Keyword(s):
Neuroactive Steroids
◽
Aminobutyric Acid
◽
Allosteric Modulator
◽
Neuroactive Steroid
◽
Next Generation
◽
Positive Allosteric Modulator
Download Full-text
Faculty Opinions recommendation of Allosteric Modulator Discovery: From Serendipity to Structure-Based Design.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
◽
10.3410/f.735179621.793557333
◽
2019
◽
Author(s):
Jean-Pierre Changeux
Keyword(s):
Allosteric Modulator
Download Full-text
para-Trifluoromethyl-methcathinone is an allosteric modulator of the serotonin transporter
Neuropharmacology
◽
10.1016/j.neuropharm.2019.04.021
◽
2019
◽
Vol 161
◽
pp. 107615
◽
Cited By ~ 2
Author(s):
Marco Niello
◽
Daniela Cintulova
◽
Eva Hellsberg
◽
Kathrin Jäntsch
◽
Marion Holy
◽
...
Keyword(s):
Serotonin Transporter
◽
Allosteric Modulator
Download Full-text
Discovery of BNC375, a Potent, Selective, and Orally Available Type I Positive Allosteric Modulator of α7 nAChRs
ACS Medicinal Chemistry Letters
◽
10.1021/acsmedchemlett.9b00001
◽
2019
◽
Vol 10
(5)
◽
pp. 754-760
◽
Cited By ~ 9
Author(s):
Andrew J. Harvey
◽
Thomas D. Avery
◽
Laurent Schaeffer
◽
Christophe Joseph
◽
Belinda C. Huff
◽
...
Keyword(s):
Allosteric Modulator
◽
Type I
◽
Positive Allosteric Modulator
◽
Α7 Nachrs
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