scholarly journals Computational Study of the Addition of Methanethiol to 40+ Michael Acceptors as a Model for the Bioconjugation of Cysteines

2021 ◽  
Author(s):  
Anna M. Costa ◽  
Lluís Bosch ◽  
Elena Petit ◽  
Jaume Vilarrasa
Keyword(s):  
Computational Study ◽  
Michael Acceptors

Determining Michael Acceptor Reactivity from Kinetic, Mechanistic, and Computational Analysis for the Base-catalyzed Thiol-Michael Reaction

2021 ◽  
Author(s):  
Sijia Huang ◽  
Kangmin Kim ◽  
Grant Musgrave ◽  
Marcus Sharp ◽  
Jasmine Sinha ◽  
...  
Keyword(s):  
Computational Analysis ◽  
Michael Reaction ◽  
Computational Study ◽  
Michael Reactions ◽  
Michael Acceptor ◽  
Michael Acceptors

A combined experimental and computational study of the reactivities of seven commonly used Michael acceptors paired with two thiols within the framework of photobase-catalyzed thiol-Michael reactions is reported. The kinetic...

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