Chemoenzymatic Total Synthesis of Hydromorphone by an Oxidative Dearomatization/Intramolecular [4 + 2] Cycloaddition Sequence: A Second-Generation Approach

2016 ◽  
Vol 81 (22) ◽  
pp. 10930-10941 ◽  
Author(s):  
Lukas Rycek ◽  
John J. Hayward ◽  
Marwa Abdel Latif ◽  
James Tanko ◽  
Razvan Simionescu ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Second Generation ◽  
Oxidative Dearomatization

Second-generation total synthesis of (−)-diversifolin

2010 ◽  
Vol 51 (14) ◽  
pp. 1876-1879 ◽  
Author(s):  
Kazuma Tsuboi ◽  
Tomoaki Nakamura ◽  
Takahiro Suzuki ◽  
Atsuo Nakazaki ◽  
Susumu Kobayashi
Keyword(s):  
Total Synthesis ◽  
Second Generation

Total Synthesis of (−)-Kainic Acid via Intramolecular Michael Addition: A Second-Generation Route

2008 ◽  
Vol 10 (9) ◽  
pp. 1711-1714 ◽  
Author(s):  
Hiroshi Sakaguchi ◽  
Hidetoshi Tokuyama ◽  
Tohru Fukuyama
Keyword(s):  
Total Synthesis ◽  
Kainic Acid ◽  
Michael Addition ◽  
Second Generation

scholarly journals Second Generation Synthesis of the Neo-Clerodane Diterpenoid Methyl Barbascoate

2013 ◽  
Vol 8 (7) ◽  
pp. 1934578X1300800 ◽  
Author(s):  
Hisahiro Hagiwara ◽  
Naomi Honma ◽  
Kimihiko Kinugawa ◽  
Shota Sato ◽  
Takashi Hoshi ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Second Generation ◽  
Samarium Diiodide ◽  
Conjugate Reduction ◽  
Palladium Catalyzed ◽  
Clerodane Diterpenoid

The second generation total synthesis of the neo-clerodane diterpenoid, methyl barbascoate, was accomplished in seven or nine linear steps via double enol triflation and subsequent palladium catalyzed double carbonylation, followed by regioselective samarium diiodide mediated conjugate reduction.

ChemInform Abstract: A Second-Generation Chemoenzymatic Total Synthesis of Platencin.

ChemInform ◽  
2016 ◽  
Vol 47 (24) ◽  
Author(s):  
Rehmani N. Muhammad ◽  
Alistair G. Draffan ◽  
Martin G. Banwell ◽  
Anthony C. Willis
Keyword(s):  
Total Synthesis ◽  
Second Generation

ChemInform Abstract: Second-Generation Total Synthesis of (-)-Diversifolin (VIII).

ChemInform ◽  
2010 ◽  
Vol 41 (29) ◽  
pp. no-no
Author(s):  
Kazuma Tsuboi ◽  
Tomoaki Nakamura ◽  
Takahiro Suzuki ◽  
Atsuo Nakazaki ◽  
Susumu Kobayashi
Keyword(s):  
Total Synthesis ◽  
Second Generation

scholarly journals Development of a Divergent Route to Erythrina Alkaloids

Synlett ◽  
2020 ◽  
Vol 31 (04) ◽  
pp. 327-333 ◽  
Author(s):  
Jesper L. Kristensen ◽  
Sebastian Clementson ◽  
Mikkel Jessing ◽  
Paulo J. Vital
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
19Th Century ◽  
First Generation ◽  
Second Generation ◽  
Enantioselective Synthesis ◽  
Third Generation ◽  
Synthetic Strategy ◽  
Erythrina Alkaloids ◽  
The 19Th Century

Erythrina alkaloids were identified at the end of the 19th century and today, more than 100 members of the erythrinane family have been isolated. They are characterized by a unique tetracyclic, α-tertiary spiroamine scaffold. Herein we detail our efforts towards the development of a divergent enantioselective synthesis of (+)-dihydro-β-erythroidine (DHβE) – one of the most prominent members of this intriguing family of natural products.1 Introduction2 Synthetic Strategy2.1 First Generation2.2 Second Generation2.3 Third Generation2.3.1 Radical Endgame2.3.2 Completion of the Total Synthesis3 Conclusion

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