Computational Study of Engineered Cytochrome P450-Catalyzed C–H Amination: The Origin of the Regio- and Stereoselectivity

2017 ◽  
Vol 121 (48) ◽  
pp. 10859-10868 ◽  
Author(s):  
Zhe Li ◽  
D. Jean Burnell ◽  
Russell J. Boyd
Keyword(s):  
Cytochrome P450 ◽  
Computational Study

Interactions of omeprazole-based analogues with cytochrome P450 2C19: a computational study

2016 ◽  
Vol 12 (6) ◽  
pp. 1913-1921 ◽  
Author(s):  
Junhao Li ◽  
Hanwen Du ◽  
Zengrui Wu ◽  
Haixia Su ◽  
Guixia Liu ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Computational Study ◽  
Drug Metabolizing Enzymes ◽  
Clinical Use ◽  
Metabolizing Enzymes ◽  
Cytochrome P450 2C19

Cytochrome P450 2C19 (CYP2C19) is one of 57 drug metabolizing enzymes in humans and is responsible for the metabolism of ∼7–10% of drugs in clinical use.

Nitric Oxide Binding to Ferric Cytochrome P450:  A Computational Study

2000 ◽  
Vol 39 (11) ◽  
pp. 2352-2359 ◽  
Author(s):  
Damián A. Scherlis ◽  
Cora B. Cymeryng ◽  
Darío A. Estrin
Keyword(s):  
Nitric Oxide ◽  
Cytochrome P450 ◽  
Computational Study

scholarly journals A Systematic Account on Aromatic Hydroxylation by a Cytochrome P450 Model Compound I: A Low-Pressure Mass Spectrometry and Computational Study

2016 ◽  
Vol 22 (51) ◽  
pp. 18608-18619 ◽  
Author(s):  
Fabián G. Cantú Reinhard ◽  
Mala A. Sainna ◽  
Pranav Upadhyay ◽  
G. Alex Balan ◽  
Devesh Kumar ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Cytochrome P450 ◽  
Model Compound ◽  
Computational Study ◽  
Low Pressure ◽  
Compound I ◽  
Systematic Account ◽  
Aromatic Hydroxylation

Cooperative Binding of Aflatoxin B1by Cytochrome P450 3A4: A Computational Study

2014 ◽  
Vol 27 (12) ◽  
pp. 2136-2147 ◽  
Author(s):  
Urban Bren ◽  
Julian E. Fuchs ◽  
Chris Oostenbrink
Keyword(s):  
Cytochrome P450 ◽  
Computational Study ◽  
Cooperative Binding ◽  
Cytochrome P450 3A4
Sign in / Sign up

Export Citation Format

Share Document