Administration Routes of Polyethylenimine-Coated PLGA Nanoparticles Encapsulating Angelica Sinensis Polysaccharide Vaccine Delivery System Affect Immune Responses

2021 ◽  
Author(s):  
Pengfei Gu ◽  
Yue Zhang ◽  
Gaofeng Cai ◽  
Zhenguang Liu ◽  
Yuanliang Hu ◽  
...  
Keyword(s):  
Immune Responses ◽  
Delivery System ◽  
Vaccine Delivery ◽  
Plga Nanoparticles ◽  
Polysaccharide Vaccine ◽  
Angelica Sinensis ◽  
Vaccine Delivery System ◽  
Administration Routes

Effect of vaccine delivery system on the induction of HPV16L1-specific humoral and cell-mediated immune responses in immunized rhesus macaques

Vaccine ◽  
2003 ◽  
Vol 21 (13-14) ◽  
pp. 1539-1547 ◽  
Author(s):  
Timothy W Tobery ◽  
Judith F Smith ◽  
Nelly Kuklin ◽  
DeeMarie Skulsky ◽  
Christopher Ackerson ◽  
...  
Keyword(s):  
Immune Responses ◽  
Delivery System ◽  
Rhesus Macaques ◽  
Vaccine Delivery ◽  
Vaccine Delivery System

scholarly journals Chemical Conjugation Strategies for the Development of Protein-Based Subunit Nanovaccines

Vaccines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 563
Author(s):  
Lantian Lu ◽  
Viet Tram Duong ◽  
Ahmed O. Shalash ◽  
Mariusz Skwarczynski ◽  
Istvan Toth
Keyword(s):  
Immune Responses ◽  
Delivery System ◽  
Immune Cells ◽  
Vaccine Delivery ◽  
Target Site ◽  
Covalent Bonds ◽  
Vaccine Delivery System ◽  
Peptide Antigens ◽  
Chemical Conjugation

The production of subunit nanovaccines relies heavily on the development of a vaccine delivery system that is safe and efficient at delivering antigens to the target site. Nanoparticles have been extensively investigated for vaccine delivery over the years, as they often possess self-adjuvanting properties. The conjugation of antigens to nanoparticles by covalent bonds ensures co-delivery of these components to the same subset of immune cells in order to trigger the desired immune responses. Herein, we review covalent conjugation strategies for grafting protein or peptide antigens onto other molecules or nanoparticles to obtain subunit nanovaccines. We also discuss the advantages of chemical conjugation in developing these vaccines.

Novel Vaccine Delivery System Induces Robust Humoral and Cellular Immune Responses Based on Multiple Mechanisms

2013 ◽  
Vol 3 (5) ◽  
pp. 670-681 ◽  
Author(s):  
Yue-Qi Wang ◽  
Jie Wu ◽  
Qing-Ze Fan ◽  
Meng Zhou ◽  
Zhan-Guo Yue ◽  
...  
Keyword(s):  
Immune Responses ◽  
Delivery System ◽  
Vaccine Delivery ◽  
Vaccine Delivery System ◽  
Cellular Immune Responses ◽  
Cellular Immune
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