Large Scale Practical Synthesis of Enantiomerically Pure cis-4-Amino-3-fluoro-1-methylpiperidine via Rhodium-Catalyzed Asymmetric Hydrogenation of a Tetrasubstituted Fluoroalkene

2021 ◽  
Vol 25 (3) ◽  
pp. 583-590 ◽  
Author(s):  
Bo Qu ◽  
Anjan Saha ◽  
Guisheng Li ◽  
Xingzhong Zeng ◽  
Xiaojun Wang ◽  
...  
Keyword(s):  
Large Scale ◽  
Asymmetric Hydrogenation ◽  
Enantiomerically Pure ◽  
Practical Synthesis

Practical Synthesis of Enantiopure ?-Amino Alcohols by Rhodium-Catalyzed Asymmetric Hydrogenation of ?-Secondary-Amino Ketones

2005 ◽  
Vol 117 (11) ◽  
pp. 1715-1717 ◽  
Author(s):  
Duan Liu ◽  
Wenzhong Gao ◽  
Chunjiang Wang ◽  
Xumu Zhang
Keyword(s):  
Asymmetric Hydrogenation ◽  
Amino Alcohols ◽  
Secondary Amino ◽  
Practical Synthesis

ChemInform Abstract: A Large-Scale Synthesis of Enantiomerically Pure γ-Hydroxyorganochalcogenides.

ChemInform ◽  
2010 ◽  
Vol 41 (23) ◽  
pp. no-no
Author(s):  
Jefferson L. Princival ◽  
Morilo S. C. de Oliveira ◽  
Alcindo A. Dos Santos ◽  
Joao V. Comasseto
Keyword(s):  
Large Scale ◽  
Enantiomerically Pure ◽  
Large Scale Synthesis

ChemInform Abstract: A Large-Scale Synthesis of Enantiomerically Pure Cetirizine Dihydrochloride Using Preparative Chiral HPLC.

ChemInform ◽  
2010 ◽  
Vol 32 (33) ◽  
pp. no-no
Author(s):  
Derek A. Pflum ◽  
H. Scott Wilkinson ◽  
Gerald J. Tanoury ◽  
Donald W. Kessler ◽  
Hali B. Kraus ◽  
...  
Keyword(s):  
Large Scale ◽  
Chiral Hplc ◽  
Enantiomerically Pure ◽  
Large Scale Synthesis

Large-Scale Practical Synthesis of Boc-Protected 4-Fluoro-l-Proline

2020 ◽  
Vol 24 (9) ◽  
pp. 1609-1613
Author(s):  
Yasinalli Tamboli ◽  
Bharat Kashid ◽  
Ram Prasad Yadav ◽  
Mohammad Rafeeq ◽  
Arvind Y Merwade
Keyword(s):  
Large Scale ◽  
Practical Synthesis

A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam

2019 ◽  
Vol 17 (1) ◽  
pp. 35-38 ◽  
Author(s):  
Iaroslav Baglai ◽  
Michel Leeman ◽  
Richard M. Kellogg ◽  
Willem L. Noorduin
Keyword(s):  
Building Block ◽  
Rational Design ◽  
Large Scale ◽  
Enantiomerically Pure ◽  
Ripening Process ◽  
Simple Route ◽  
Chiral Component ◽  
Design And Application

A simple route to enantiomerically pure (S)-2-aminobutyramide – the chiral component of the anti-epileptic drugs Levetiracetam and Brivaracetam has been developed. This approach is based on the rational design and application of a Viedma ripening process. The practical potential of the process is demonstrated on a large scale.

ChemInform Abstract: Axial [6,6′-(2,4-Pentadioxy)]-1,1′-biphenyl-2,2′-diamine (PD-BIPHAM): Practical Synthesis and Applications in Asymmetric Hydrogenation.

ChemInform ◽  
2010 ◽  
Vol 41 (39) ◽  
pp. no-no
Author(s):  
Chun-Jiang Wang ◽  
Zhong-Ping Xu ◽  
Xiang Wang ◽  
Huai-Long Teng
Keyword(s):  
Asymmetric Hydrogenation ◽  
Practical Synthesis

Practical synthesis of enantiomerically pure myo-inositol derivatives

1992 ◽  
Vol 33 (8) ◽  
pp. 1009-1012 ◽  
Author(s):  
Karol S. Bruzik ◽  
Jeffrey Myers ◽  
Ming-Daw Tsai
Keyword(s):  
Enantiomerically Pure ◽  
Practical Synthesis
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