Asymmetric Synthesis of the Cyclohexyl Fragment in RORγt Inhibitor (BMS-986251) Enabled by a Dynamic Kinetic Resolution of Hageman’s Ester

2021 ◽  
Author(s):  
William P. Gallagher ◽  
John R. Coombs ◽  
Carlos A. Guerrero ◽  
Boguslaw M. Mudryk ◽  
Kishta Katipally ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Kinetic Resolution ◽  
Dynamic Kinetic Resolution

Asymmetric Synthesis of a Key Intermediate for Tofacitinib via a Dynamic Kinetic Resolution-Reductive Amination Protocol

2018 ◽  
Vol 22 (12) ◽  
pp. 1817-1822 ◽  
Author(s):  
Gerard K. M. Verzijl ◽  
Christian Schuster ◽  
Thomas Dax ◽  
André H. M. de Vries ◽  
Laurent Lefort
Keyword(s):  
Asymmetric Synthesis ◽  
Reductive Amination ◽  
Kinetic Resolution ◽  
Dynamic Kinetic Resolution

Asymmetric Synthesis of QUINAP via Dynamic Kinetic Resolution

2013 ◽  
Vol 135 (45) ◽  
pp. 16829-16832 ◽  
Author(s):  
Vikram Bhat ◽  
Su Wang ◽  
Brian M. Stoltz ◽  
Scott C. Virgil
Keyword(s):  
Asymmetric Synthesis ◽  
Kinetic Resolution ◽  
Dynamic Kinetic Resolution

A new cost-effective Ru-chloramphenicol base derivative catalyst for the asymmetric transfer hydrogenation/dynamic kinetic resolution of N-Boc α-amino-β-ketoesters and its application to the synthesis of the chiral core of vancomycin

RSC Advances ◽  
2016 ◽  
Vol 6 (44) ◽  
pp. 37701-37709 ◽  
Author(s):  
Xinlong Wang ◽  
Lingjun Xu ◽  
Fangjun Xiong ◽  
Yan Wu ◽  
Fener Chen
Keyword(s):  
Asymmetric Synthesis ◽  
Kinetic Resolution ◽  
Cost Effective ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
Dynamic Kinetic Resolution ◽  
Amino Esters ◽  
Base Derivative

Herein we describe the application of Ru-chloramphenicol base complexes catalyzed highly diastereo- and enantioselective transfer hydrogenation of N-Boc α-amino-β-ketoesters for the asymmetric synthesis of anti-N-Boc-β-hydroxy-α-amino esters.

scholarly journals Asymmetric Synthesis of Diverse Glycolic Acid Scaffolds via Dynamic Kinetic Resolution of α-Keto Esters

2012 ◽  
Vol 134 (49) ◽  
pp. 20197-20206 ◽  
Author(s):  
Kimberly M. Steward ◽  
Michael T. Corbett ◽  
C. Guy Goodman ◽  
Jeffrey S. Johnson
Keyword(s):  
Asymmetric Synthesis ◽  
Glycolic Acid ◽  
Kinetic Resolution ◽  
Dynamic Kinetic Resolution ◽  
Keto Esters
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