Overcoming Chemical Challenges in the Solid-Phase Synthesis of High-Purity GnRH Antagonist Degarelix. Part 1.

2019 ◽  
Vol 23 (12) ◽  
pp. 2746-2753 ◽  
Author(s):  
Ivan Guryanov ◽  
Andrea Orlandin ◽  
Angelo Viola ◽  
Barbara Biondi ◽  
Denis Badocco ◽  
...  
Keyword(s):  
High Purity ◽  
Gnrh Antagonist ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis

Overcoming Chemical Challenges in the Solid-Phase Synthesis of High-Purity GnRH Antagonist Degarelix. Part 2

2020 ◽  
Vol 24 (2) ◽  
pp. 274-278
Author(s):  
Ivan Guryanov ◽  
Andrea Orlandin ◽  
Angelo Viola ◽  
Barbara Biondi ◽  
Fernando Formaggio ◽  
...  
Keyword(s):  
High Purity ◽  
Gnrh Antagonist ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis

scholarly journals Solid-phase synthesis and fluorine-18 radiolabeling of cycloRGDyK

2016 ◽  
Vol 14 (37) ◽  
pp. 8659-8663 ◽  
Author(s):  
Ryan A. Davis ◽  
Kevin Lau ◽  
Sven H. Hausner ◽  
Julie L. Sutcliffe
Keyword(s):  
Peptide Synthesis ◽  
High Purity ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Continuous Process ◽  
Solid Support ◽  
Purification Step ◽  
Phase Synthesis

A rapid, efficient single continuous process for peptide synthesis, cyclization, and radiolabeling on solid-support with a single purification step afforded a high purity radiotracer.

Novel and Efficient Solid-Phase Synthesis of 4,6-Disubstituted 4,5-Dihydro-3(2H)-Pyridazinones

2003 ◽  
Vol 2003 (9) ◽  
pp. 599-600
Author(s):  
Jing Tang ◽  
Xian Huang
Keyword(s):  
High Purity ◽  
Good Yield ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Malonic Ester ◽  
Polymeric Support ◽  
Subsequent Reaction ◽  
Phase Synthesis

The resin-bound 5-monosubstituted cyclic malonic ester 3 was generated and reacted with an α–bromoketone to give the corresponding 5,5-disubstituted cyclic malonic ester resin (4). Subsequent reaction with hydrazine resulted in cyclisation with concomitant cleavage from the polymeric support to release the final products, 4,6-disubstituted 4,5-dihydro-3(2 H)-pyridazinones, in good yield and high purity.

Solid-phase synthesis of aryl vinyl ethers based on polystyrene-supported β-phenylselenoethanol

2009 ◽  
Vol 2009 (5) ◽  
pp. 287-289 ◽  
Author(s):  
Jia-Li Zhang ◽  
Shou-Ri Sheng ◽  
Xue Liu ◽  
Shu-Ying Lin
Keyword(s):  
Hydrogen Peroxide ◽  
Organic Synthesis ◽  
High Purity ◽  
Good Yield ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Vinyl Ethers ◽  
Phase Synthesis ◽  
Subsequent Oxidation ◽  
Solid Phase Organic Synthesis

A novel facile solid-phase organic synthesis of aryl vinyl ethers by reaction of polystyrene-supported β-phenylselenoethanol with phenols under Mitsunobu conditions and subsequent oxidation-elimination with 30% hydrogen peroxide has been developed. The advantages of this method include straightforward operation, lack of odour, good yield and high purity of the products.

Solid Phase synthesis of Amides Using Mukaiyama'S Reagent

2003 ◽  
Vol 2003 (1) ◽  
pp. 10-11
Author(s):  
Bin Tao ◽  
David W. Boykin
Keyword(s):  
High Purity ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Synthetic Method ◽  
Phase Synthesis ◽  
Mild Conditions

A new solid-phase synthetic method using Mukaiyama's reagent under mild conditions is reported to prepare amides in high purity without purification after cleavage from the resins.

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