Novel and Efficient Solid-Phase Synthesis of 4,6-Disubstituted 4,5-Dihydro-3(2H)-Pyridazinones

2003 ◽  
Vol 2003 (9) ◽  
pp. 599-600
Author(s):  
Jing Tang ◽  
Xian Huang
Keyword(s):  
High Purity ◽  
Good Yield ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Malonic Ester ◽  
Polymeric Support ◽  
Subsequent Reaction ◽  
Phase Synthesis

The resin-bound 5-monosubstituted cyclic malonic ester 3 was generated and reacted with an α–bromoketone to give the corresponding 5,5-disubstituted cyclic malonic ester resin (4). Subsequent reaction with hydrazine resulted in cyclisation with concomitant cleavage from the polymeric support to release the final products, 4,6-disubstituted 4,5-dihydro-3(2 H)-pyridazinones, in good yield and high purity.

Solid-phase synthesis of aryl vinyl ethers based on polystyrene-supported β-phenylselenoethanol

2009 ◽  
Vol 2009 (5) ◽  
pp. 287-289 ◽  
Author(s):  
Jia-Li Zhang ◽  
Shou-Ri Sheng ◽  
Xue Liu ◽  
Shu-Ying Lin
Keyword(s):  
Hydrogen Peroxide ◽  
Organic Synthesis ◽  
High Purity ◽  
Good Yield ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Vinyl Ethers ◽  
Phase Synthesis ◽  
Subsequent Oxidation ◽  
Solid Phase Organic Synthesis

A novel facile solid-phase organic synthesis of aryl vinyl ethers by reaction of polystyrene-supported β-phenylselenoethanol with phenols under Mitsunobu conditions and subsequent oxidation-elimination with 30% hydrogen peroxide has been developed. The advantages of this method include straightforward operation, lack of odour, good yield and high purity of the products.

The solid phase synthesis of monoester monoamides and monoester monoalcohols from symmetrical diacid chlorides

1978 ◽  
Vol 56 (11) ◽  
pp. 1562-1568 ◽  
Author(s):  
Judah M. Goldwasser ◽  
Clifford C. Leznoff
Keyword(s):  
Benzyl Alcohol ◽  
Good Yield ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Borohydride Reduction ◽  
Subsequent Reaction ◽  
Terephthaloyl Chloride ◽  
Phase Synthesis ◽  
Tert Butylamine ◽  
Isophthaloyl Chloride

A 2% crosslinked divinylbenzene–styrene copolymer, incorporating benzyl alcohol groups, was used to monoprotect the symmetrical diacid chlorides, ClOC(CH2)nCOCl (where n = 2, 3, 4, and 8), terephthaloyl chloride and isophthaloyl chloride. Subsequent reaction of the resulting polymer-bound monoester monoacid chloride with aniline, benzylamine, dimethylamine, tert-butylamine, or ammonia yielded polymer-bound monoester monoamides, which on base cleavage and esterification gave monoester monoamides inhighyield. Borohydride reduction of polymer-bound sebacoyl chloride, terephthaloyl chloride, and isophthaloyl chloride gave their respective polymer-bound monoester monoalcohols, which on base cleavage from the polymer and esterification yielded the monoester monoalcohols in good yield along with some recovered dimethyl esters of the respective starting diacid chlorides.

Overcoming Chemical Challenges in the Solid-Phase Synthesis of High-Purity GnRH Antagonist Degarelix. Part 1.

2019 ◽  
Vol 23 (12) ◽  
pp. 2746-2753 ◽  
Author(s):  
Ivan Guryanov ◽  
Andrea Orlandin ◽  
Angelo Viola ◽  
Barbara Biondi ◽  
Denis Badocco ◽  
...  
Keyword(s):  
High Purity ◽  
Gnrh Antagonist ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis

scholarly journals Solid-phase synthesis and fluorine-18 radiolabeling of cycloRGDyK

2016 ◽  
Vol 14 (37) ◽  
pp. 8659-8663 ◽  
Author(s):  
Ryan A. Davis ◽  
Kevin Lau ◽  
Sven H. Hausner ◽  
Julie L. Sutcliffe
Keyword(s):  
Peptide Synthesis ◽  
High Purity ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Continuous Process ◽  
Solid Support ◽  
Purification Step ◽  
Phase Synthesis

A rapid, efficient single continuous process for peptide synthesis, cyclization, and radiolabeling on solid-support with a single purification step afforded a high purity radiotracer.

Solid-phase synthesis of peptides on the polymeric support TRILAR�

1992 ◽  
Vol 28 (2) ◽  
pp. 226-230
Author(s):  
L. K. Lubsandorzhieva ◽  
B. Khalil' ◽  
G. A. Zheltukhina ◽  
R. P. Evstigneeva
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Polymeric Support ◽  
Phase Synthesis
Sign in / Sign up

Export Citation Format

Share Document