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<p>Amphiphilic ligands are valued for their ability to
facilitate organometallic reactions in the presence of water. The regioselective
sulfonation of a series of commercially available biaryl monophosphines to
generate amphiphilic ligands is presented. In this one-step protocol, the
temperature and addition of fuming sulfuric acid were carefully controlled to
arrive at sulfonated biaryl monophosphine ligands in high yields with >95%
regioselectivity without the need for chromatographic purification.</p>
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Amphiphilic Biaryl Monophosphine Ligands by Regioselective Sulfonation