The interest in organophosphorus compounds with a C-P bond is due to their
wide use in various fields, especially in medicine and agrochemistry. Prominent examples
of anti-cancer, antibacterial, and anti-HIV agents are therapeutic candidates containing a
phosphonic acid group fragment. This review provides modern synthetic methods for obtaining
phosphorylated aromatic and heteroaromatic compounds with the participation of
complexes and salts of various metals developed in recent years as well modern protocol -
electrochemical synthesis which allows carrying out reactions at room temperature and
normal pressure with no additional oxidants or bases. Herein, we demonstrate new trends
and evolution of phosphorylation reactions in catalysis.
2-Fluoro-5-nitrobenzonitrile,
an analogue of 1-fluoro-2,4- dinitrobenzene, in which the 2-nitro group has
been replaced by a cyano group, has been prepared and made to react with
several amines, amino acids, and NH-heteroaromatic compounds. The proton magnetic
resonance spectra of some of the resultant N-(2-cyano-4-nitrophenyl)
derivatives were compared with the spectra of the corresponding N-(2,4- dinitrophenyl)
derivatives and furnish further evidence that the ortho nitro group of the
latter derivatives is rotated out of the plane of the aromatic nucleus.
The reaction of N-heteroaromatic compounds, such as 2-aryl-pyrrole, benzimidazole, imidazole, indole, and pyrazole derivatives, with alkynes in the presence of a catalytic amount of a nickel complex results in C–H/N–H oxidative annulation.
Transition Metal‐Free Synthesis of Polyfunctional Triarylmethanes and 1,1‐Diarylalkanes by Sequential Cross‐Coupling of Benzal Diacetates with Organozinc Reagents