Сatalytic Phosphorylation of Aromatic C-H Bonds: from Traditional Approaches to Electrochemistry

The interest in organophosphorus compounds with a C-P bond is due to their wide use in various fields, especially in medicine and agrochemistry. Prominent examples of anti-cancer, antibacterial, and anti-HIV agents are therapeutic candidates containing a phosphonic acid group fragment. This review provides modern synthetic methods for obtaining phosphorylated aromatic and heteroaromatic compounds with the participation of complexes and salts of various metals developed in recent years as well modern protocol - electrochemical synthesis which allows carrying out reactions at room temperature and normal pressure with no additional oxidants or bases. Herein, we demonstrate new trends and evolution of phosphorylation reactions in catalysis.

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Plants as a source of anti-cancer and anti-HIV agents

Annals of Applied Biology ◽

10.1111/j.1744-7348.2003.tb00278.x ◽

2003 ◽

Vol 143 (2) ◽

pp. 127-133 ◽

Cited By ~ 45

Author(s):

G M CRAGG ◽

D J NEWMAN

Keyword(s):

Anti Cancer ◽

Anti Hiv Agents ◽

Anti Hiv

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Some uses of transition metal complexes as anti-cancer and anti-HIV agents

Dalton Transactions ◽

10.1039/b705079h ◽

2007 ◽

pp. 4884 ◽

Cited By ~ 46

Author(s):

Raymond Wai-Yin Sun ◽

Dik-Lung Ma ◽

Ella Lai-Ming Wong ◽

Chi-Ming Che

Keyword(s):

Transition Metal ◽

Metal Complexes ◽

Transition Metal Complexes ◽

Anti Cancer ◽

Anti Hiv Agents ◽

Anti Hiv

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Marine Natural Products as Lead Anti-HIV Agents

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557033487962 ◽

2003 ◽

Vol 3 (5) ◽

pp. 401-424 ◽

Cited By ~ 42

Author(s):

D. Gochfeld ◽

K. El Sayed ◽

M. Yousaf ◽

J. Hu ◽

P. Bartyzel ◽

...

Keyword(s):

Natural Products ◽

Marine Natural Products ◽

Anti Hiv Agents ◽

Anti Hiv

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Rational Design of Colchicine Derivatives as anti-HIV Agents via QSAR and Molecular Docking

Medicinal Chemistry ◽

10.2174/1573406414666180924163756 ◽

2019 ◽

Vol 15 (4) ◽

pp. 328-340 ◽

Cited By ~ 3

Author(s):

Apilak Worachartcheewan ◽

Napat Songtawee ◽

Suphakit Siriwong ◽

Supaluk Prachayasittikul ◽

Chanin Nantasenamat ◽

...

Keyword(s):

Molecular Docking ◽

Rational Design ◽

External Validation ◽

Rational Drug Design ◽

Support Vector ◽

Data Set ◽

Qsar Models ◽

Anti Hiv Agents ◽

Anti Hiv ◽

Colchicine Derivatives

Background: Human immunodeficiency virus (HIV) is an infective agent that causes an acquired immunodeficiency syndrome (AIDS). Therefore, the rational design of inhibitors for preventing the progression of the disease is required. Objective: This study aims to construct quantitative structure-activity relationship (QSAR) models, molecular docking and newly rational design of colchicine and derivatives with anti-HIV activity. Methods: A data set of 24 colchicine and derivatives with anti-HIV activity were employed to develop the QSAR models using machine learning methods (e.g. multiple linear regression (MLR), artificial neural network (ANN) and support vector machine (SVM)), and to study a molecular docking. Results: The significant descriptors relating to the anti-HIV activity included JGI2, Mor24u, Gm and R8p+ descriptors. The predictive performance of the models gave acceptable statistical qualities as observed by correlation coefficient (Q2) and root mean square error (RMSE) of leave-one out cross-validation (LOO-CV) and external sets. Particularly, the ANN method outperformed MLR and SVM methods that displayed LOO−CV 2 Q and RMSELOO-CV of 0.7548 and 0.5735 for LOOCV set, and Ext 2 Q of 0.8553 and RMSEExt of 0.6999 for external validation. In addition, the molecular docking of virus-entry molecule (gp120 envelope glycoprotein) revealed the key interacting residues of the protein (cellular receptor, CD4) and the site-moiety preferences of colchicine derivatives as HIV entry inhibitors for binding to HIV structure. Furthermore, newly rational design of colchicine derivatives using informative QSAR and molecular docking was proposed. Conclusion: These findings serve as a guideline for the rational drug design as well as potential development of novel anti-HIV agents.

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