Isostearyl Mixed Anhydrides for the Preparation of N-Methylated Peptides Using C-Terminally Unprotected N-Methylamino Acids

2020 ◽  
Vol 22 (20) ◽  
pp. 8039-8043 ◽  
Author(s):  
Haruaki Kurasaki ◽  
Akihiro Nagaya ◽  
Yutaka Kobayashi ◽  
Ayumu Matsuda ◽  
Masatoshi Matsumoto ◽  
...  
Keyword(s):  
Mixed Anhydrides

ChemInform Abstract: ACTIVATION OF CARBOXYLIC ACIDS AS DIPHENYLPHOSPHINIC MIXED ANHYDRIDES. APPLICATION TO PEPTIDE CHEMISTRY

1976 ◽  
Vol 7 (52) ◽  
pp. no-no
Author(s):  
A. G. JACKSON ◽  
G. W. KENNER ◽  
G. A. MOORE ◽  
R. RAMAGE ◽  
W. D. THORPE
Keyword(s):  
Carboxylic Acids ◽  
Peptide Chemistry ◽  
Mixed Anhydrides

ChemInform Abstract: The Active Mixed Anhydrides of Phosphorous PH-Acids.

ChemInform ◽  
2010 ◽  
Vol 22 (1) ◽  
pp. no-no
Author(s):  
N. A. KARDANOV ◽  
A. M. TIMOFEEV ◽  
G. A. KVASHNINA ◽  
S. A. TRIFONOVA ◽  
N. N. GODOVIKOV ◽  
...  
Keyword(s):  
Mixed Anhydrides

Mixed anhydrides of ?-mercuriohexafluoroisobutyric acids

1979 ◽  
Vol 28 (8) ◽  
pp. 1692-1697 ◽  
Author(s):  
I. L. Knunyants ◽  
E. M. Rokhlin ◽  
A. Yu. Volkonskii
Keyword(s):  
Mixed Anhydrides

scholarly journals How Prebiotic Chemistry and Early Life Chose Phosphate

Life ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 26 ◽  
Author(s):  
Ziwei Liu ◽  
Jean-Christophe Rossi ◽  
Robert Pascal
Keyword(s):  
Chemical Evolution ◽  
Early Life ◽  
Prebiotic Chemistry ◽  
Protein Biosynthesis ◽  
Phosphate Esters ◽  
Early Stages ◽  
Mixed Anhydrides ◽  
Living Organisms ◽  
Intrinsic Reactivity ◽  
Thermodynamic Instability

The very specific thermodynamic instability and kinetic stability of phosphate esters and anhydrides impart them invaluable properties in living organisms in which highly efficient enzyme catalysts compensate for their low intrinsic reactivity. Considering their role in protein biosynthesis, these properties raise a paradox about early stages: How could these species be selected in the absence of enzymes? This review is aimed at demonstrating that considering mixed anhydrides or other species more reactive than esters and anhydrides can help in solving the paradox. The consequences of this approach for chemical evolution and early stages of life are analysed.

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