Pd-catalyzed Regio- and Stereoselective Hydrostannylation of an Alkyl Ethynyl Ether/One-Pot Stille Coupling Enables the Synthesis of 14-Membered Macrolactone of Luminamicin
A practical one-pot approach for the synthesis of arylalkynyl-substituted terminal alkynes has been developed through a deprotection/ stannylation of a phenylethynyl phosphine oxide followed by Migita–Kosugi–Stille coupling, avoiding the longer synthetic route involving repeated deprotection/Sonogashira coupling. Other features of this approach include mild reaction conditions, excellent yields, facile isolation of products and wide functional group tolerance.
This paper reports a facile one-pot synthesis of mesoporous graphitic carbon nitride (mpg-CN) supported Pd NPs, denoted as mpg-CN/Pd, as highly efficient catalysts for Stille C–C coupling reactions under mild conditions.
( Z)-1,2-Disubstituted vinyl sulfides can be stereoselectively synthesised in one pot under mild conditions, in good yields, by the palladium-catalysed hydrostannylation of acetylenic sulfides, followed by Stille coupling with aryl iodides.
