d-Retroenantiomer of Quorum-Sensing Peptide-Modified Polymeric Micelles for Brain Tumor-Targeted Drug Delivery

2017 ◽  
Vol 9 (31) ◽  
pp. 25672-25682 ◽  
Author(s):  
Danni Ran ◽  
Jiani Mao ◽  
Changyou Zhan ◽  
Cao Xie ◽  
Huitong Ruan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Brain Tumor ◽  
Quorum Sensing ◽  
Targeted Drug Delivery ◽  
Polymeric Micelles ◽  
Targeted Drug

scholarly journals Thermosensitive polymeric micelles for targeted drug delivery

Nanomedicine ◽  
2011 ◽  
Vol 6 (7) ◽  
pp. 1245-1255 ◽  
Author(s):  
Marina Talelli ◽  
Wim E Hennink
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Polymeric Micelles ◽  
Targeted Drug

Mathematical modeling and optimal control problems in brain tumor targeted drug delivery strategies

2017 ◽  
Vol 10 (04) ◽  
pp. 1750056 ◽  
Author(s):  
Aziz Belmiloudi
Keyword(s):  
Drug Delivery ◽  
Optimal Control ◽  
Brain Tumor ◽  
Targeted Drug Delivery ◽  
Optimal Control Problems ◽  
Control Problems ◽  
Mathematical Framework ◽  
Normal Cells ◽  
Regularity Of Solution ◽  
Targeted Drug

In this paper, we present a mathematical model that describes tumor-normal cells interaction dynamics focusing on role of drugs in treatment of brain tumors. The goal is to predict distribution and necessary quantity of drugs delivered in drug-therapy by using optimal control framework. The model describes interactions of tumor and normal cells using a system of reactions–diffusion equations involving the drug concentration, tumor cells and normal tissues. The control estimates simultaneously blood perfusion rate, reabsorption rate of drug and drug dosage administered, which affect the effects of brain tumor chemotherapy. First, we develop mathematical framework which models the competition between tumor and normal cells under chemotherapy constraints. Then, existence, uniqueness and regularity of solution of state equations are proved as well as stability results. Afterwards, optimal control problems are formulated in order to minimize the drug delivery and tumor cell burden in different situations. We show existence and uniqueness of optimal solution, and we derive necessary conditions for optimality. Finally, to solve numerically optimal control and optimization problems, we propose and investigate an adjoint multiple-relaxation-time lattice Boltzmann method for a general nonlinear coupled anisotropic convection–diffusion system (which includes the developed model for brain tumor targeted drug delivery system).

Development of Chitosan-Based pH-Sensitive Polymeric Micelles Containing Curcumin for Colon-Targeted Drug Delivery

2017 ◽  
Vol 19 (3) ◽  
pp. 991-1000 ◽  
Author(s):  
Thisirak Woraphatphadung ◽  
Warayuth Sajomsang ◽  
Theerasak Rojanarata ◽  
Tanasait Ngawhirunpat ◽  
Prasopchai Tonglairoum ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Polymeric Micelles ◽  
Ph Sensitive ◽  
Targeted Drug

Long circulating biodegradable polymeric micelles: Towards targeted drug delivery

2008 ◽  
Vol 132 (3) ◽  
pp. e33-e35 ◽  
Author(s):  
C.J.F. Rijcken ◽  
R.M. Schiffelers ◽  
C.F. van Nostrum ◽  
W.E. Hennink
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Polymeric Micelles ◽  
Targeted Drug

Synthesis of polymeric micelles with dual-functional sheddable PEG stealth for enhanced tumor-targeted drug delivery

2020 ◽  
Vol 11 (27) ◽  
pp. 4469-4476 ◽  
Author(s):  
Lu Sun ◽  
Hua Wei ◽  
Xianshuo Zhang ◽  
Chao Meng ◽  
Guiying Kang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Targeted Drug Delivery ◽  
Polymeric Micelles ◽  
Anticancer Drug Delivery ◽  
Dual Functional ◽  
Targeted Drug

We reported the synthesis of polymeric micelles with a dual-functional sheddable mPEG stealth to realize simultaneously tumor-triggered targeting and intracellular micelle destabilization for enhanced anticancer drug delivery.

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