Comparison of Pharmacological Properties between the Kappa Opioid Receptor Agonist Nalfurafine and 42B, Its 3-Dehydroxy Analogue: Disconnect between in Vitro Agonist Bias and in Vivo Pharmacological Effects

Danni Cao; Peng Huang; Yi-Ting Chiu; Chongguang Chen; Huiqun Wang; Mengchu Li; Yi Zheng; Frederick J. Ehlert; Yan Zhang; Lee-Yuan Liu-Chen

doi:10.1021/acschemneuro.0c00407

Comparison of Pharmacological Properties between the Kappa Opioid Receptor Agonist Nalfurafine and 42B, Its 3-Dehydroxy Analogue: Disconnect between in Vitro Agonist Bias and in Vivo Pharmacological Effects

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.0c00407 ◽

2020 ◽

Vol 11 (19) ◽

pp. 3036-3050 ◽

Cited By ~ 1

Author(s):

Danni Cao ◽

Peng Huang ◽

Yi-Ting Chiu ◽

Chongguang Chen ◽

Huiqun Wang ◽

...

Keyword(s):

Opioid Receptor ◽

Receptor Agonist ◽

Kappa Opioid Receptor ◽

Pharmacological Properties ◽

Pharmacological Effects ◽

Kappa Opioid ◽

Opioid Receptor Agonist

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The Kappa-Opioid Receptor Agonist MR-2034 Stimulates the Rat Hypothalamic-Pituitary-Adrenal Axis: Studies in vivo and in vitro

Journal of Neuroendocrinology ◽

10.1046/j.1365-2826.1996.04962.x ◽

1996 ◽

Vol 8 (8) ◽

pp. 579-585 ◽

Cited By ~ 1

Author(s):

A. E. Calogero ◽

S. Scaccianoce ◽

N. Burrello ◽

R. Nicolai ◽

L. A. A. Muscolo ◽

...

Keyword(s):

Opioid Receptor ◽

Receptor Agonist ◽

Kappa Opioid Receptor ◽

Kappa Opioid ◽

Hypothalamic Pituitary Adrenal ◽

Adrenal Axis ◽

Opioid Receptor Agonist ◽

Pituitary Adrenal Axis

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In vitro and in vivo Pharmacological Activities of 14-O-Phenylpropyloxymorphone, a Potent Mixed Mu/Delta/Kappa-Opioid Receptor Agonist With Reduced Constipation in Mice

Frontiers in Pharmacology ◽

10.3389/fphar.2018.01002 ◽

2018 ◽

Vol 9 ◽

Cited By ~ 2

Author(s):

Roberta Lattanzi ◽

Silvia Rief ◽

Helmut Schmidhammer ◽

Lucia Negri ◽

Mariana Spetea

Keyword(s):

Opioid Receptor ◽

Receptor Agonist ◽

Kappa Opioid Receptor ◽

Kappa Opioid ◽

Pharmacological Activities ◽

Opioid Receptor Agonist

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Novel Kappa Opioid Receptor Agonist as Improved PET Radiotracer: Development and in Vivo Evaluation

Molecular Pharmaceutics ◽

10.1021/acs.molpharmaceut.8b01209 ◽

2019 ◽

Vol 16 (4) ◽

pp. 1523-1531 ◽

Cited By ~ 2

Author(s):

Songye Li ◽

Ming-Qiang Zheng ◽

Mika Naganawa ◽

Hong Gao ◽

Richard Pracitto ◽

...

Keyword(s):

Opioid Receptor ◽

Receptor Agonist ◽

Kappa Opioid Receptor ◽

Kappa Opioid ◽

In Vivo Evaluation ◽

Opioid Receptor Agonist

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Partial kappa opioid receptor agonist effects in vivo in mice: Biased versus unbiased

Drug and Alcohol Dependence ◽

10.1016/j.drugalcdep.2016.08.223 ◽

2017 ◽

Vol 171 ◽

pp. e78-e79

Author(s):

Catherine Guariglia ◽

Amelia Dunn ◽

Kyle Windisch ◽

Eduardo Butelman ◽

Brian Reed ◽

...

Keyword(s):

Opioid Receptor ◽

Receptor Agonist ◽

Kappa Opioid Receptor ◽

Kappa Opioid ◽

Opioid Receptor Agonist

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The G protein-biased kappa opioid receptor agonist 6′-GNTI blocks hippocampal paroxysmal discharges without inducing aversion

Intrinsic Activity ◽

10.25006/ia.3.s2-a2.14 ◽

2015 ◽

Vol 3 (Suppl. 2) ◽

pp. A2.14

Author(s):

Luca Zangrandi

Keyword(s):

G Protein ◽

Opioid Receptor ◽

Receptor Agonist ◽

Kappa Opioid Receptor ◽

Kappa Opioid ◽

Opioid Receptor Agonist

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Itching-like behavior: A common effect of the kappa opioid receptor antagonist 5'-guanidinonaltrindole and the biased kappa opioid receptor agonist 6'-guanidinonaltrindole in mice

Medicine in Drug Discovery ◽

10.1016/j.medidd.2021.100097 ◽

2021 ◽

pp. 100097

Author(s):

Alan Cowan ◽

Lee-Yuan Liu-Chen ◽

Saadet Inan

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Receptor Agonist ◽

Kappa Opioid Receptor ◽

Kappa Opioid ◽

Opioid Receptor Antagonist ◽

Common Effect ◽

Opioid Receptor Agonist

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Effect of Difelikefalin, a Selective Kappa Opioid Receptor Agonist, on Respiratory Depression: A Randomized, Double‐Blind, Placebo‐Controlled Trial

Clinical and Translational Science ◽

10.1111/cts.13042 ◽

2021 ◽

Author(s):

Eugene R. Viscusi ◽

Marc C. Torjman ◽

Catherine L. Munera ◽

Joseph W. Stauffer ◽

Beatrice S. Setnik ◽

...

Keyword(s):

Respiratory Depression ◽

Opioid Receptor ◽

Receptor Agonist ◽

Controlled Trial ◽

Kappa Opioid Receptor ◽

Kappa Opioid ◽

Double Blind ◽

Double Blind Placebo ◽

Opioid Receptor Agonist

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Blockade of ethanol reward by the kappa opioid receptor agonist U50,488H

Alcohol ◽

10.1016/j.alcohol.2009.05.001 ◽

2009 ◽

Vol 43 (5) ◽

pp. 359-365 ◽

Cited By ~ 53

Author(s):

Marian L. Logrip ◽

Patricia H. Janak ◽

Dorit Ron

Keyword(s):

Opioid Receptor ◽

Receptor Agonist ◽

Kappa Opioid Receptor ◽

Kappa Opioid ◽

Opioid Receptor Agonist

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A unique binding epitope for salvinorin A, a non-nitrogenous kappa opioid receptor agonist

FEBS Journal ◽

10.1111/j.1742-4658.2006.05212.x ◽

2006 ◽

Vol 273 (9) ◽

pp. 1966-1974 ◽

Cited By ~ 27

Author(s):

Brian E. Kane ◽

Marcelo J. Nieto ◽

Christopher R. McCurdy ◽

David M. Ferguson

Keyword(s):

Opioid Receptor ◽

Receptor Agonist ◽

Kappa Opioid Receptor ◽

Salvinorin A ◽

Kappa Opioid ◽

Opioid Receptor Agonist ◽

Binding Epitope

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The Kappa-Opioid Receptor Agonist MR-2034 Stimulates the Rat Hypothalamic-Pituitary-Adrenal Axis: Studiesin vivoandin vitro

Journal of Neuroendocrinology ◽

10.1111/j.1365-2826.1996.tb00691.x ◽

1996 ◽

Vol 8 (8) ◽

pp. 579-585 ◽

Cited By ~ 31

Author(s):

A. E. Calogero ◽

S. Scaccianoce ◽

N. Burrello ◽

R. Nicolai ◽

L. A. A. Muscolo ◽

...

Keyword(s):

Opioid Receptor ◽

Receptor Agonist ◽

Kappa Opioid Receptor ◽

Hypothalamic Pituitary Adrenal Axis ◽

Kappa Opioid ◽

Hypothalamic Pituitary Adrenal ◽

Adrenal Axis ◽

Opioid Receptor Agonist ◽

Pituitary Adrenal Axis

Download Full-text