An Enantiodefined Conformationally Constrained Fatty Acid Mimetic and Potent Inhibitor of ToxT

2021 ◽  
Author(s):  
Lauren E. Markham ◽  
Jessica D. Tolbert ◽  
F. Jon Kull ◽  
Charles R. Midgett ◽  
Glenn C. Micalizio
Keyword(s):  
Fatty Acid ◽  
Potent Inhibitor ◽  
Conformationally Constrained

scholarly journals Aurintricarboxylic acid is a potent inhibitor of phosphofructokinase

1989 ◽  
Vol 259 (3) ◽  
pp. 925-927 ◽  
Author(s):  
S A McCune ◽  
L G Foe ◽  
R G Kemp ◽  
R R Jurin
Keyword(s):  
Protein Synthesis ◽  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Potent Inhibitor ◽  
Rat Hepatocytes ◽  
Acid Synthesis ◽  
Rabbit Liver ◽  
Irreversible Binding ◽  
Aurintricarboxylic Acid ◽  
Inhibitory Site

Aurintricarboxylic acid (ATA) was found to be a very potent inhibitor of purified rabbit liver phosphofructokinase (PFK), giving 50% inhibition at 0.2 microM. The inhibition was in a manner consistent with interaction at the citrate-inhibitory site of the enzyme. The data suggest that inhibition of PFK by ATA was not due to denaturation of the enzyme or the irreversible binding of inhibitor, since the inhibition could be reversed by addition of allosteric activators of PFK, i.e. fructose 2,6-bisphosphate or AMP. Two other tricarboxylic acids, agaric acid and (-)-hydroxycitrate, were found to inhibit PFK. ATA at much higher concentrations (500 microM) was shown to inhibit fatty acid synthesis from endogenous glycogen in rat hepatocytes; however, protein synthesis was not altered.

Depside as potent inhibitor of prostaglandin biosynthesis: A new active site model for fatty acid cyclooxygenase

1982 ◽  
Vol 24 (1) ◽  
pp. 21-34 ◽  
Author(s):  
Ushio Sankawa ◽  
Masaaki Shibuya ◽  
Yutaka Ebizuka ◽  
Hiroshi Noguchi ◽  
Yoichi Iitaka ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Active Site ◽  
Potent Inhibitor ◽  
Prostaglandin Biosynthesis ◽  
Site Model ◽  
Active Site Model

scholarly journals Oleic acid is a potent inhibitor of fatty acid and cholesterol synthesis in C6 glioma cells

2007 ◽  
Vol 48 (9) ◽  
pp. 1966-1975 ◽  
Author(s):  
Francesco Natali ◽  
Luisa Siculella ◽  
Serafina Salvati ◽  
Gabriele V. Gnoni
Keyword(s):  
Oleic Acid ◽  
Fatty Acid ◽  
Cholesterol Synthesis ◽  
Potent Inhibitor ◽  
Glioma Cells ◽  
C6 Glioma ◽  
C6 Glioma Cells

scholarly journals Alphalinolenic acid, a potent inhibitor of fatty acid synthase antimycobacterial agent

2014 ◽  
Vol 14 (Suppl 3) ◽  
pp. E19
Author(s):  
Mallika Jainu ◽  
A Hemaprabha ◽  
S Vinutha ◽  
Sarah Rajitha ◽  
TS Ranjani
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthase ◽  
Potent Inhibitor

scholarly journals The fatty acid oxidation product 15-A3t-Isoprostane is a potent inhibitor of NFκB transcription and macrophage transformation

2011 ◽  
Vol 119 (3) ◽  
pp. 604-616 ◽  
Author(s):  
Joshua D. Brooks ◽  
Erik S. Musiek ◽  
Tyler R. Koestner ◽  
Jeannette N. Stankowski ◽  
Jocelyn R. Howard ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Oxidation Product ◽  
Potent Inhibitor ◽  
Acid Oxidation

Conformationally Constrained Fatty Acid Ethanolamides as Cannabinoid and Vanilloid Receptor Probes

2009 ◽  
Vol 52 (9) ◽  
pp. 3001-3009 ◽  
Author(s):  
Giovanni Appendino ◽  
Alessia Ligresti ◽  
Alberto Minassi ◽  
Maria Grazia Cascio ◽  
Marco Allarà ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Vanilloid Receptor ◽  
Conformationally Constrained ◽  
Fatty Acid Ethanolamides

Epicatechin conjugated with fatty acid is a potent inhibitor of DNA polymerase and angiogenesis

Life Sciences ◽  
2007 ◽  
Vol 80 (17) ◽  
pp. 1578-1585 ◽  
Author(s):  
Kiminori Matsubara ◽  
Akiko Saito ◽  
Akira Tanaka ◽  
Noriyuki Nakajima ◽  
Reiko Akagi ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Dna Polymerase ◽  
Potent Inhibitor
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