Evaluation of DNA Methyltransferase Activity and Inhibition via Isothermal Enzyme-Free Concatenated Hybridization Chain Reaction

ACS Sensors ◽  
2017 ◽  
Vol 2 (7) ◽  
pp. 932-939 ◽  
Author(s):  
Qing Wang ◽  
Min Pan ◽  
Jie Wei ◽  
Xiaoqing Liu ◽  
Fuan Wang
Keyword(s):  
Dna Methyltransferase ◽  
Hybridization Chain Reaction ◽  
Methyltransferase Activity ◽  
Chain Reaction

An electrochemiluminescence assay for sensitive detection of methyltransferase activity in different cancer cells by hybridization chain reaction coupled with a G-quadruplex/hemin DNAzyme biosensing strategy

The Analyst ◽  
2017 ◽  
Vol 142 (11) ◽  
pp. 2013-2019 ◽  
Author(s):  
Hui Zhang ◽  
Zhihui Guo ◽  
Huilei Dong ◽  
Hongfei Chen ◽  
Chenxin Cai
Keyword(s):  
Cancer Cells ◽  
Sensitive Detection ◽  
Hybridization Chain Reaction ◽  
Methyltransferase Activity ◽  
Chain Reaction ◽  
G Quadruplex

A sensitive electrochemiluminescence assay coupled HCR with a G-quadruplex/hemin DNAzyme was fabricated for the detection of DNMT1 activity in cancer cells.

A new method for the in situ assay of α-glucosidase activity and inhibitor screening through an enzyme substrate-mediated DNA hybridization chain reaction

2019 ◽  
Vol 43 (24) ◽  
pp. 9458-9465
Author(s):  
Xiquan Yue ◽  
Lihong Su ◽  
Xu Chen ◽  
Junfeng Liu ◽  
Longpo Zheng ◽  
...  
Keyword(s):  
Small Molecule ◽  
Dna Hybridization ◽  
New Method ◽  
Hybridization Chain Reaction ◽  
Chain Reaction ◽  
Inhibitor Screening ◽  
Glucosidase Activity ◽  
Enzyme Substrate ◽  
In Situ Assay

The strategy is based on small molecule-mediated hybridization chain reaction.

Ultrasensitive ratiometric detection of Pb2+ using DNA tetrahedron-mediated hyperbranched hybridization chain reaction

2021 ◽  
Vol 1147 ◽  
pp. 170-177
Author(s):  
Pingping Ji ◽  
Guimei Han ◽  
Yan Huang ◽  
Hongxin Jiang ◽  
Qiwen Zhou ◽  
...  
Keyword(s):  
Hybridization Chain Reaction ◽  
Chain Reaction ◽  
Ratiometric Detection ◽  
Dna Tetrahedron
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